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SYPL2 synaptophysin like 2 [ Homo sapiens (human) ]

Gene ID: 284612, updated on 23-Nov-2021

Summary

Official Symbol
SYPL2provided by HGNC
Official Full Name
synaptophysin like 2provided by HGNC
Primary source
HGNC:HGNC:27638
See related
Ensembl:ENSG00000143028
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MG29
Expression
Broad expression in kidney (RPKM 4.9), testis (RPKM 4.8) and 20 other tissues See more
Orthologs
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Genomic context

See SYPL2 in Genome Data Viewer
Location:
1p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (109466478..109482142)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110009168..110024756)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene sortilin 1 Neighboring gene proteasome 20S subunit alpha 5 Neighboring gene Sharpr-MPRA regulatory region 8825 Neighboring gene ataxin 7 like 2 Neighboring gene cytochrome b561 family member D1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of recurrent early-onset major depressive disorder.
GeneReviews: Not available
New loci associated with kidney function and chronic kidney disease.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in T-tubule organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in substantia nigra development HEP PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
synaptophysin-like protein 2
Names
mitsugumin 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040709.2NP_001035799.1  synaptophysin-like protein 2

    See identical proteins and their annotated locations for NP_001035799.1

    Status: VALIDATED

    Source sequence(s)
    AI983207, AL355145, DA097637, DB071160, DB291596, DN831287
    Consensus CDS
    CCDS41365.1
    UniProtKB/Swiss-Prot
    Q5VXT5
    Related
    ENSP00000358888.3, ENST00000369872.4
    Conserved Domains (1) summary
    pfam01284
    Location:30232
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    109466478..109482142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541285.1XP_011539587.1  synaptophysin-like protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011539587.1

    UniProtKB/TrEMBL
    B4DYR7
    Conserved Domains (1) summary
    pfam01284
    Location:30162
    MARVEL; Membrane-associating domain
  2. XM_011541283.2XP_011539585.1  synaptophysin-like protein 2 isoform X1

    Conserved Domains (1) summary
    pfam01284
    Location:30232
    MARVEL; Membrane-associating domain
  3. XM_011541284.2XP_011539586.1  synaptophysin-like protein 2 isoform X2

    Conserved Domains (1) summary
    pfam01284
    Location:30162
    MARVEL; Membrane-associating domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001006603.1: Suppressed sequence

    Description
    NM_001006603.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
  2. NM_198280.1: Suppressed sequence

    Description
    NM_198280.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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