Sypl2 synaptophysin-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sypl2provided by MGI
Official Full Name: synaptophysin-like 2provided by MGI
Primary source: MGI:MGI:1328311
See related: Ensembl:ENSMUSG00000027887 AllianceGenome:MGI:1328311
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mg29
Summary: Acts upstream of or within T-tubule organization; cellular calcium ion homeostasis; and heart development. Predicted to be located in membrane and synaptic vesicle. Predicted to be integral component of membrane. Predicted to be active in synaptic vesicle membrane. Is expressed in heart ventricle. Orthologous to human SYPL2 (synaptophysin like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in mammary gland adult (RPKM 12.7), kidney adult (RPKM 10.8) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3; 3 F2.3- F3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (108119582..108133915, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (108210410..108226989, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ca(2+) transients in skeletal muscle are regulated via interaction between Mg29 and TRPC3.
Title: Interaction between mitsugumin 29 and TRPC3 participates in regulating Ca(2+) transients in skeletal muscle.
MG29 is not involved in the store-operated Ca2+ entry activation at variance with the previous conclusion with immature muscles
Title: Changes in Ca2+ handling in adult MG29-deficient skeletal muscle.
Data show that slow cumulative calcium entry through store-operated calcium channel (SOC) is crucial for long-term calcium homeostasis, such that reduced SOC activity exaggerates muscle fatigue under conditions of intensive exercise.
Title: Dysfunction of store-operated calcium channel in muscle cells lacking mg29.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

AB010144 (e-PCR)
- UniSTS:163329

AW822238 (e-PCR)
- UniSTS:207552

Homology

Homologs of the Sypl2 gene: The Sypl2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 441 organisms have orthologs with human gene Sypl2
Orthologs

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within T-tubule organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: synaptophysin-like protein 2

Names: mitsugumin 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.