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SIGLECL1 SIGLEC family like 1 [ Homo sapiens (human) ]

Gene ID: 284369, updated on 8-Dec-2022

Summary

Official Symbol
SIGLECL1provided by HGNC
Official Full Name
SIGLEC family like 1provided by HGNC
Primary source
HGNC:HGNC:26856
See related
Ensembl:ENSG00000179213 AllianceGenome:HGNC:26856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C19orf75; SIGLECP7; SIGLEC23P
Summary
Predicted to enable sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 8.3) See more
Orthologs
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Genomic context

See SIGLECL1 in Genome Data Viewer
Location:
19q13.41
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51246332..51269330)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54334953..54357956)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51749587..51772584)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985327 Neighboring gene uncharacterized LOC124904751 Neighboring gene microRNA 8074 Neighboring gene sialic acid binding Ig like lectin 22, pseudogene Neighboring gene CD33 molecule Neighboring gene long intergenic non-protein coding RNA 1872 Neighboring gene uncharacterized LOC107985326 Neighboring gene SIGLEC family like 1 pseudogene Neighboring gene sialic acid binding Ig like lectin 24, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40235, MGC161635, MGC161637

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
SIGLEC family-like protein 1
Names
sialic acid binding Ig-like lectin, pseudogene 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308437.2NP_001295366.1  SIGLEC family-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001295366.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon compared to variant 4. It encodes isoform 2, which is shorter than isoform 1. Variants 3 and 6 both encode the same isoform (2).
    Source sequence(s)
    AC063977
    Consensus CDS
    CCDS77341.1
    UniProtKB/TrEMBL
    B7ZLS6
  2. NM_001385465.1NP_001372394.1  SIGLEC family-like protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longer isoform (1). Variants 1, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AC063977
    Consensus CDS
    CCDS12827.1
    UniProtKB/Swiss-Prot
    Q8N7X8
    Related
    ENSP00000469601.2, ENST00000601727.6
    Conserved Domains (2) summary
    cd00096
    Location:2327
    Ig; Ig strand B [structural motif]
    cl11960
    Location:2191
    Ig; Immunoglobulin domain
  3. NM_001385466.1NP_001372395.1  SIGLEC family-like protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Variants 1, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AC063977
    Consensus CDS
    CCDS12827.1
    UniProtKB/Swiss-Prot
    Q8N7X8
    Related
    ENSP00000480286.1, ENST00000614422.4
    Conserved Domains (2) summary
    cd00096
    Location:2327
    Ig; Ig strand B [structural motif]
    cl11960
    Location:2191
    Ig; Immunoglobulin domain
  4. NM_001385467.1NP_001372396.1  SIGLEC family-like protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks an in-frame exon compared to variant 4. It encodes isoform 2, which is shorter than isoform 1. Variants 3 and 6 both encode the same isoform (2).
    Source sequence(s)
    AC063977
    Consensus CDS
    CCDS77341.1
    UniProtKB/TrEMBL
    B7ZLS6
    Related
    ENSP00000472702.1, ENST00000597824.1
  5. NM_173635.3NP_775906.1  SIGLEC family-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_775906.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AC063977
    Consensus CDS
    CCDS12827.1
    UniProtKB/Swiss-Prot
    Q8N7X8
    Related
    ENSP00000321249.6, ENST00000316401.11
    Conserved Domains (2) summary
    cd00096
    Location:2327
    Ig; Ig strand B [structural motif]
    cl11960
    Location:2191
    Ig; Immunoglobulin domain

RNA

  1. NR_102324.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate internal exons compared to variant 4. This variant is represented as non-coding because it lacks the entire coding region found in variant 4.
    Source sequence(s)
    AA454064, AC063977, AK097554, AK311591
  2. NR_169626.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC063977
  3. NR_169627.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC063977

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51246332..51269330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526821.2XP_011525123.1  SIGLEC family-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011525123.1

    UniProtKB/Swiss-Prot
    Q8N7X8
    Conserved Domains (2) summary
    cd00096
    Location:2327
    Ig; Ig strand B [structural motif]
    cl11960
    Location:2191
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    54334953..54357956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)