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ENDOV endonuclease V [ Homo sapiens (human) ]

Gene ID: 284131, updated on 5-Aug-2022

Summary

Official Symbol
ENDOVprovided by HGNC
Official Full Name
endonuclease Vprovided by HGNC
Primary source
HGNC:HGNC:26640
See related
Ensembl:ENSG00000173818 MIM:619821; AllianceGenome:HGNC:26640
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables DNA binding activity; endoribonuclease activity, producing 5'-phosphomonoesters; and single-stranded RNA binding activity. Predicted to be involved in DNA repair. Located in cytoplasmic stress granule and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 3.1), prostate (RPKM 2.3) and 25 other tissues See more
Orthologs
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Genomic context

See ENDOV in Genome Data Viewer
Location:
17q25.3
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (80415167..80438086)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (81317021..81339980)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (78388967..78411886)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr17.5742 Neighboring gene ring finger protein 213 Neighboring gene RNF213 antisense RNA 1 Neighboring gene microRNA 4730 Neighboring gene Sharpr-MPRA regulatory region 3125 Neighboring gene neuronal pentraxin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35220, MGC74455

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables endodeoxyribonuclease activity, producing 5'-phosphomonoesters IDA
Inferred from Direct Assay
more info
PubMed 
enables endodeoxyribonuclease activity, producing 5'-phosphomonoesters ISS
Inferred from Sequence or Structural Similarity
more info
 
enables endoribonuclease activity, producing 5'-phosphomonoesters IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables endoribonuclease activity, producing 5'-phosphomonoesters IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables magnesium ion binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
endonuclease V
Names
hEndoV
inosine-specific endoribonuclease
NP_001158109.1
NP_001158110.1
NP_001339689.1
NP_001339690.1
NP_775898.2
XP_005257303.1
XP_006721900.1
XP_011522957.1
XP_011522958.1
XP_011522959.1
XP_011522960.1
XP_011522962.1
XP_011522963.1
XP_011522964.1
XP_011522965.1
XP_011522968.1
XP_011522969.1
XP_011522971.1
XP_011522972.1
XP_011522973.1
XP_016879997.1
XP_016879999.1
XP_016880002.1
XP_047291765.1
XP_047291766.1
XP_047291767.1
XP_047291768.1
XP_047291769.1
XP_047291770.1
XP_047291771.1
XP_047291772.1
XP_047291773.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164637.3NP_001158109.1  endonuclease V isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120024, AK092539, AK096344, BM714470, KC877673
    Consensus CDS
    CCDS54173.1
    UniProtKB/Swiss-Prot
    Q8N8Q3
    Related
    ENSP00000431036.1, ENST00000520367.5
    Conserved Domains (1) summary
    cd06559
    Location:17200
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  2. NM_001164638.3NP_001158110.1  endonuclease V isoform 3

    See identical proteins and their annotated locations for NP_001158110.1

    Status: VALIDATED

    Source sequence(s)
    AK092539, BC064545
    Consensus CDS
    CCDS54174.1
    UniProtKB/Swiss-Prot
    Q8N8Q3
    Related
    ENSP00000317810.5, ENST00000323854.9
    Conserved Domains (1) summary
    cd06559
    Location:17200
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  3. NM_001352760.3NP_001339689.1  endonuclease V isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC120024, BU553848
    Conserved Domains (1) summary
    cd06559
    Location:17245
    Endonuclease_V; a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  4. NM_001352761.3NP_001339690.1  endonuclease V isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC120024
    Conserved Domains (1) summary
    cd06559
    Location:17245
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  5. NM_173627.5NP_775898.2  endonuclease V isoform 1

    See identical proteins and their annotated locations for NP_775898.2

    Status: VALIDATED

    Source sequence(s)
    AC120024, AK096344, BM714470, KC877673
    Consensus CDS
    CCDS54172.1
    UniProtKB/Swiss-Prot
    Q8N8Q3, Q8NAK0
    Related
    ENSP00000429190.1, ENST00000518137.6
    Conserved Domains (1) summary
    cd06559
    Location:17245
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases

RNA

  1. NR_148041.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC120024, BM714470, KC877673
  2. NR_148042.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC120024, BM714470, KC877673
  3. NR_148043.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC120024, BM714470, KC877673
  4. NR_148044.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC120024, BM714470, KC877673
    Related
    ENST00000520284.5
  5. NR_148045.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC120024, BM714470, KC877673
    Related
    ENST00000517795.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    80415167..80438086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524658.3XP_011522960.1  endonuclease V isoform X5

    Conserved Domains (1) summary
    cd06559
    Location:17258
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  2. XM_011524669.3XP_011522971.1  endonuclease V isoform X13

    Conserved Domains (1) summary
    cd06559
    Location:17256
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  3. XM_011524670.2XP_011522972.1  endonuclease V isoform X16

    Conserved Domains (1) summary
    cd06559
    Location:17249
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  4. XM_011524671.3XP_011522973.1  endonuclease V isoform X19

    Conserved Domains (1) summary
    cd06559
    Location:17238
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  5. XM_011524666.2XP_011522968.1  endonuclease V isoform X12

    See identical proteins and their annotated locations for XP_011522968.1

    Conserved Domains (1) summary
    cd06559
    Location:1175
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  6. XM_047435817.1XP_047291773.1  endonuclease V isoform X21

  7. XM_047435811.1XP_047291767.1  endonuclease V isoform X12

  8. XM_047435812.1XP_047291768.1  endonuclease V isoform X12

  9. XM_017024508.2XP_016879997.1  endonuclease V isoform X12

    Conserved Domains (1) summary
    cd06559
    Location:1175
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  10. XM_047435813.1XP_047291769.1  endonuclease V isoform X12

  11. XM_017024513.2XP_016880002.1  endonuclease V isoform X21

    Related
    ENSP00000430639.1, ENST00000519331.1
    Conserved Domains (1) summary
    cl00653
    Location:153
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  12. XM_011524667.3XP_011522969.1  endonuclease V isoform X12

    See identical proteins and their annotated locations for XP_011522969.1

    Conserved Domains (1) summary
    cd06559
    Location:1175
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  13. XM_011524655.2XP_011522957.1  endonuclease V isoform X1

    Conserved Domains (1) summary
    cd06559
    Location:17258
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  14. XM_011524662.2XP_011522964.1  endonuclease V isoform X9

    Conserved Domains (1) summary
    cd06559
    Location:17256
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  15. XM_011524657.2XP_011522959.1  endonuclease V isoform X3

    Conserved Domains (1) summary
    cd06559
    Location:17247
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  16. XM_006721837.4XP_006721900.1  endonuclease V isoform X11

    Conserved Domains (1) summary
    cd06559
    Location:17245
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  17. XM_011524660.1XP_011522962.1  endonuclease V isoform X7

    Conserved Domains (1) summary
    cd06559
    Location:17213
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  18. XM_011524661.3XP_011522963.1  endonuclease V isoform X8

    Conserved Domains (1) summary
    cd06559
    Location:17202
    Endonuclease_V; a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  19. XM_005257246.4XP_005257303.1  endonuclease V isoform X17

    Conserved Domains (1) summary
    cd06559
    Location:17200
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  20. XM_011524656.2XP_011522958.1  endonuclease V isoform X2

    Conserved Domains (1) summary
    cd06559
    Location:17258
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  21. XM_011524663.2XP_011522965.1  endonuclease V isoform X10

    Conserved Domains (1) summary
    cd06559
    Location:17256
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  22. XM_047435809.1XP_047291765.1  endonuclease V isoform X4

  23. XM_047435816.1XP_047291772.1  endonuclease V isoform X18

  24. XM_017024510.2XP_016879999.1  endonuclease V isoform X20

  25. XM_047435815.1XP_047291771.1  endonuclease V isoform X15

  26. XM_047435810.1XP_047291766.1  endonuclease V isoform X6

  27. XM_047435814.1XP_047291770.1  endonuclease V isoform X14

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    81317021..81339980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)