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Endov endonuclease V [ Mus musculus (house mouse) ]

Gene ID: 338371, updated on 5-Jan-2023

Summary

Official Symbol
Endovprovided by MGI
Official Full Name
endonuclease Vprovided by MGI
Primary source
MGI:MGI:2444688
See related
Ensembl:ENSMUSG00000039850 AllianceGenome:MGI:2444688
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A730011L01Rik
Summary
Enables endodeoxyribonuclease activity, producing 5'-phosphomonoesters and magnesium ion binding activity. Involved in DNA repair. Predicted to be located in cytoplasmic stress granule. Predicted to be active in cytoplasm and nucleolus. Orthologous to human ENDOV (endonuclease V). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 5.4), limb E14.5 (RPKM 5.2) and 28 other tissues See more
Orthologs
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Genomic context

See Endov in Genome Data Viewer
Location:
11; 11 E2
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119382173..119402291)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (119491322..119511465)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 1932 Neighboring gene ring finger protein 213 Neighboring gene RIKEN cDNA A930037H05 gene Neighboring gene predicted gene, 39484 Neighboring gene neuronal pentraxin 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA endonuclease activity, producing 5'-phosphomonoesters IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA endonuclease activity, producing 5'-phosphomonoesters ISO
Inferred from Sequence Orthology
more info
 
enables endodeoxyribonuclease activity, producing 5'-phosphomonoesters IDA
Inferred from Direct Assay
more info
PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
endonuclease V
Names
novel endonuclease V protein
putative endonuclease FLJ39025 homolog
NP_001158108.1
NP_796368.1
XP_006533652.1
XP_011247389.1
XP_036012680.1
XP_036012681.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164636.1NP_001158108.1  endonuclease V isoform 1

    See identical proteins and their annotated locations for NP_001158108.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK084233, AL645911, BC056486
    Consensus CDS
    CCDS48999.1
    UniProtKB/Swiss-Prot
    Q8C3Y1, Q8C9A2
    Related
    ENSMUSP00000101851.3, ENSMUST00000106244.9
    Conserved Domains (1) summary
    cd06559
    Location:17245
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  2. NM_001402059.1NP_001388988.1  endonuclease V isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL645911
  3. NM_001402060.1NP_001388989.1  endonuclease V isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645911
  4. NM_177394.3NP_796368.1  endonuclease V isoform 2

    See identical proteins and their annotated locations for NP_796368.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents an alternate 5' splice pattern and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL645911, BC056486, BY266398
    Consensus CDS
    CCDS25718.1
    UniProtKB/Swiss-Prot
    Q8C9A2
    Related
    ENSMUSP00000132755.2, ENSMUST00000106245.9
    Conserved Domains (1) summary
    cd06559
    Location:7162
    Endonuclease_V; Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases

RNA

  1. NR_174994.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL645911

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    119382173..119402291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249087.3XP_011247389.1  endonuclease V isoform X4

    Conserved Domains (1) summary
    cd06559
    Location:17245
    Endonuclease_V; a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  2. XM_036156787.1XP_036012680.1  endonuclease V isoform X1

    Conserved Domains (1) summary
    cd06559
    Location:17245
    Endonuclease_V; a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  3. XM_006533589.4XP_006533652.1  endonuclease V isoform X2

    Conserved Domains (1) summary
    cd06559
    Location:17245
    Endonuclease_V; a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases
  4. XM_036156788.1XP_036012681.1  endonuclease V isoform X3

    Conserved Domains (1) summary
    cd06559
    Location:8177
    Endonuclease_V; a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases

RNA

  1. XR_004936981.1 RNA Sequence

  2. XR_388482.4 RNA Sequence

  3. XR_001780021.2 RNA Sequence

    Related
    ENSMUST00000143817.8
  4. XR_004936983.1 RNA Sequence

  5. XR_004936982.1 RNA Sequence