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CLEC18C C-type lectin domain family 18 member C [ Homo sapiens (human) ]

Gene ID: 283971, updated on 5-Aug-2022

Summary

Official Symbol
CLEC18Cprovided by HGNC
Official Full Name
C-type lectin domain family 18 member Cprovided by HGNC
Primary source
HGNC:HGNC:28538
See related
Ensembl:ENSG00000157335 MIM:616573; AllianceGenome:HGNC:28538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRCL; MRCL3
Summary
Enables polysaccharide binding activity. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and endosome. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney (RPKM 27.4) and testis (RPKM 7.1) See more
Orthologs
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Genomic context

See CLEC18C in Genome Data Viewer
Location:
16q22.1
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (70173787..70186895)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (75984837..75997950)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70207690..70220798)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10 pseudogene 24 Neighboring gene pyruvate dehydrogenase phosphatase regulatory subunit Neighboring gene uncharacterized LOC400541 Neighboring gene uncharacterized LOC105371328 Neighboring gene small nucleolar RNA U13 Neighboring gene SMG1 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC34761

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables polysaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables polysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
located_in endosome TAS
Traceable Author Statement
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
C-type lectin domain family 18 member C
Names
mannose receptor-like 3
mannose receptor-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173619.4NP_775890.2  C-type lectin domain family 18 member C precursor

    See identical proteins and their annotated locations for NP_775890.2

    Status: VALIDATED

    Source sequence(s)
    AC009060
    Consensus CDS
    CCDS32473.1
    UniProtKB/Swiss-Prot
    Q8IUW8, Q8NCF0
    Related
    ENSP00000444875.2, ENST00000541793.7
    Conserved Domains (2) summary
    cd00037
    Location:310434
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cd05380
    Location:50183
    SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    70173787..70186895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433992.1XP_047289948.1  C-type lectin domain family 18 member C isoform X2

  2. XM_047433991.1XP_047289947.1  C-type lectin domain family 18 member C isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    75984837..75997950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)