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IGHV4-31 immunoglobulin heavy variable 4-31 [ Homo sapiens (human) ]

Gene ID: 28396, updated on 2-Nov-2024

Summary

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Official Symbol
IGHV4-31provided by HGNC
Official Full Name
immunoglobulin heavy variable 4-31provided by HGNC
Primary source
HGNC:HGNC:5649
See related
IMGT/GENE-DB:IGHV4-31; AllianceGenome:HGNC:5649
Gene type
other
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IGHV431
Summary
Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
not in current annotation release
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Genomic context

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See IGHV4-31 in Genome Data Viewer
Location:
14q32.33
Annotation release Status Assembly Chr Location
105 latest, but not current GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (106805207..106805644, complement)
105 latest, but not current HuRef (GCF_000002125.1) 14 AC_000146.1 (86942185..86942622, complement)
105 latest, but not current CHM1_1.1 (GCF_000306695.2) 14 NC_018925.2 (106686239..106686676, complement)

Bibliography

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Related articles in PubMed

  1. Immunoglobulin gamma heavy chain gene with somatic hypermutation is frequently expressed in acute myeloid leukemia. Qiu X, et al. Leukemia, 2013 Jan. PMID 22772058
  2. Development of a cocktail of recombinant-expressed human rabies virus-neutralizing monoclonal antibodies for postexposure prophylaxis of rabies. Prosniak M, et al. J Infect Dis, 2003 Jul 1. PMID 12825170
  3. Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis. Vajdos FF, et al. J Mol Biol, 2002 Jul 5. PMID 12079396
  4. Selection of a human anti-RhD monoclonal antibody for therapeutic use: impact of IgG glycosylation on activating and inhibitory Fc gamma R functions. Sibéril S, et al. Clin Immunol, 2006 Feb-Mar. PMID 16332457
  5. Chromosomal organization of the human VH4 gene family. Location of individual gene segments. van der Maarel S, et al. J Immunol, 1993 Apr 1. PMID 8454861

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Immunoglobulin gamma heavy chain gene with somatic hypermutation is frequently expressed in acute myeloid leukemia.
    Title: Immunoglobulin gamma heavy chain gene with somatic hypermutation is frequently expressed in acute myeloid leukemia.
Submit: New GeneRIF Correction

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • anti-RhD monoclonal T125 gamma1 heavy chain

Clone Names

  • FLJ45507

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in immunoglobulin mediated immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of immunoglobulin complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DP07.1 GenPept UniProtKB/Swiss-Prot:P0DP07

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials