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PGP phosphoglycolate phosphatase [ Homo sapiens (human) ]

Gene ID: 283871, updated on 24-Nov-2020

Summary

Official Symbol
PGPprovided by HGNC
Official Full Name
phosphoglycolate phosphataseprovided by HGNC
Primary source
HGNC:HGNC:8909
See related
Ensembl:ENSG00000184207 MIM:172280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AUM; G3PP; PGPase
Expression
Broad expression in testis (RPKM 12.7), brain (RPKM 7.6) and 25 other tissues See more
Orthologs

Genomic context

See PGP in Genome Data Viewer
Location:
16p13.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (2211593..2214840, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2261603..2264822, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene TNF receptor associated factor 7 Neighboring gene CASK interacting protein 1 Neighboring gene MTOR associated protein, LST8 homolog Neighboring gene Sharpr-MPRA regulatory region 11897 Neighboring gene Sharpr-MPRA regulatory region 5944 Neighboring gene BRICHOS domain containing 5 Neighboring gene E4F transcription factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the PGP gene: The PGP gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 306 organisms have orthologs with human gene PGP
  • Orthologs

Clone Names

  • MGC4692

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glycerol-1-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
glycerol-3-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerol-3-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleotide phosphatase activity, acting on free nucleotides ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphoglycolate phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
glycerol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
glycerophospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerophospholipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glycerol-3-phosphate phosphatase
Names
aspartate-based ubiquitous Mg(2+)-dependent phosphatase
NP_001035830.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042371.3NP_001035830.1  glycerol-3-phosphate phosphatase

    See identical proteins and their annotated locations for NP_001035830.1

    Status: VALIDATED

    Source sequence(s)
    AC009065, AK026146, AW161386, BC035985, DA336356
    Consensus CDS
    CCDS42104.1
    UniProtKB/Swiss-Prot
    A6NDG6
    Related
    ENSP00000330918.7, ENST00000333503.8
    Conserved Domains (3) summary
    TIGR01452
    Location:28315
    PGP_euk; phosphoglycolate/pyridoxal phosphate phosphatase family
    pfam13242
    Location:232315
    Hydrolase_like; HAD-hyrolase-like
    pfam13344
    Location:31138
    Hydrolase_6; Haloacid dehalogenase-like hydrolase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    2211593..2214840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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