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Pgp phosphoglycolate phosphatase [ Mus musculus (house mouse) ]

Gene ID: 67078, updated on 12-May-2024

Summary

Official Symbol
Pgpprovided by MGI
Official Full Name
phosphoglycolate phosphataseprovided by MGI
Primary source
MGI:MGI:1914328
See related
Ensembl:ENSMUSG00000043445 AllianceGenome:MGI:1914328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AUM; G3PP; 1700012G19Rik
Summary
Enables magnesium ion binding activity and phosphatase activity. Involved in glycerol biosynthetic process; glycerophospholipid metabolic process; and peptidyl-tyrosine dephosphorylation. Predicted to be active in cytoplasm. Orthologous to human PGP (phosphoglycolate phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 702.9), adrenal adult (RPKM 264.5) and 15 other tissues See more
Orthologs
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Genomic context

See Pgp in Genome Data Viewer
Location:
17 A3.3; 17 12.39 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24689400..24692084)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24470426..24473110)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene E4F transcription factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E3189 Neighboring gene RIKEN cDNA 4833447I15 gene Neighboring gene STARR-positive B cell enhancer ABC_E7497 Neighboring gene STARR-positive B cell enhancer ABC_E5578 Neighboring gene STARR-seq mESC enhancer starr_42087 Neighboring gene BRICHOS domain containing 5 Neighboring gene MTOR associated protein, LST8 homolog (S. cerevisiae) Neighboring gene CASK interacting protein 1 Neighboring gene TNF receptor-associated factor 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Clone Names

  • MGC103027

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glycerol-1-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables glycerol-3-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glycerol-3-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glycerol-3-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoglycolate phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
glycerol-3-phosphate phosphatase
Names
PGPase
aspartate-based ubiquitous Mg(2+)-dependent phosphatase
NP_080230.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025954.4NP_080230.2  glycerol-3-phosphate phosphatase

    See identical proteins and their annotated locations for NP_080230.2

    Status: VALIDATED

    Source sequence(s)
    AC154237
    Consensus CDS
    CCDS28482.1
    UniProtKB/Swiss-Prot
    Q8CHP8
    Related
    ENSMUSP00000052866.7, ENSMUST00000053024.8
    Conserved Domains (1) summary
    cd07510
    Location:28319
    HAD_Pase_UmpH-like; UmpH/NagD family phosphatase, similar to human PGP phosphoglycolate phosphatase and Schizosaccharomyces pombe PHO2 p-nitrophenylphosphatase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24689400..24692084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)