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TSLIG3B tRNA splicing ligase complex subunit 3B [ Homo sapiens (human) ]

Gene ID: 283742, updated on 5-Aug-2026
Official Symbol
TSLIG3Bprovided by HGNC
Official Full Name
tRNA splicing ligase complex subunit 3Bprovided by HGNC
Primary source
HGNC:HGNC:26773
See related
Ensembl:ENSG00000171262 MIM:616142; AllianceGenome:HGNC:26773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM98B
Summary
Enables identical protein binding activity and protein methyltransferase activity. Involved in positive regulation of cell population proliferation; positive regulation of gene expression; and protein methylation. Located in cytoplasm and nucleoplasm. Part of tRNA-splicing ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in brain (RPKM 11.0), endometrium (RPKM 8.6) and 25 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See TSLIG3B in Genome Data Viewer
Location:
15q14
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (38454127..38487710)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (36259418..36292996)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (38746328..38779911)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:38364669-38365534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6298 Neighboring gene long independently transcribed non-coding RNA 1852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9198 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9200 Neighboring gene Sharpr-MPRA regulatory region 4108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6300 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6303 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6304 Neighboring gene MPRA-validated peak2297 silencer Neighboring gene sprouty related EVH1 domain containing 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:38679220-38679403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9202 Neighboring gene CTD small phosphatase 2 pseudogene Neighboring gene uncharacterized LOC105370774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9204 Neighboring gene RAS guanyl releasing protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9206 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6305 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:38857079-38857590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6307 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6306 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:38885521-38886720 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9211 Neighboring gene uncharacterized LOC105370775 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9213

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Polyglycine-mediated aggregation of FAM98B disrupts tRNA processing in GGC repeat disorders. Yang J, et al. Science, 2025 Jul 17. PMID 40674500, Free PMC Article
  2. FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression. Akter KA, et al. Int J Biochem Cell Biol, 2017 Mar. PMID 28040436
  3. hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex. Pérez-González A, et al. PLoS One, 2014. PMID 24608264, Free PMC Article
  4. Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors. Popow J, et al. Nature, 2014 Jul 3. PMID 24870230, Free PMC Article
  5. Genome-wide association study of atypical psychosis. Kanazawa T, et al. Am J Med Genet B Neuropsychiatr Genet, 2013 Oct. PMID 24132900

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the two structural homologs FAM98A and FAM98B included in a novel complex with DDX1 and C14orf166 are required for PRMT1 expression in colorectal cancer cell lines
    Title: FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.
  2. hCLE/C14orf166 associates with DDX1, HSPC117, and FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.
    Title: hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of atypical psychosis.
EBI GWAS Catalog
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, family with sequence similarity 98, member B (FAM98B), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with FAM98B is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ38426

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA splicing, via endonucleolytic cleavage and ligation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
part_of tRNA-splicing ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tRNA-splicing ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of tRNA-splicing ligase complex NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
tRNA-splicing ligase complex subunit FAM98B
Names
family with sequence similarity 98 member B
protein FAM98B

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173611.4 → NP_775882.2  tRNA-splicing ligase complex subunit FAM98B

    Status: VALIDATED

    Source sequence(s)
    AI638256, BC035600, BC045690, BP872319, BU633364, BX454964, DA118586, DA520319, DB552059
    Consensus CDS
    CCDS10047.2
    UniProtKB/Swiss-Prot
    A8MUW5, Q52LJ0, Q8N935
    Related
    ENSP00000380734.2, ENST00000397609.6
    Conserved Domains (1) summary
    pfam10239
    Location:17 → 330
    DUF2465; Protein of unknown function (DUF2465)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    38454127..38487710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    36259418..36292996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001042429.1: Suppressed sequence

    Description
    NM_001042429.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q52LJ0.2 GenPept UniProtKB/Swiss-Prot:Q52LJ0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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