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FAM98B family with sequence similarity 98 member B [ Homo sapiens (human) ]

Gene ID: 283742, updated on 5-Sep-2021

Summary

Official Symbol
FAM98Bprovided by HGNC
Official Full Name
family with sequence similarity 98 member Bprovided by HGNC
Primary source
HGNC:HGNC:26773
See related
Ensembl:ENSG00000171262 MIM:616142
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in brain (RPKM 11.0), endometrium (RPKM 8.6) and 25 other tissues See more
Orthologs
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Genomic context

See FAM98B in Genome Data Viewer
Location:
15q14
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (38454127..38487710)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (38746328..38779911)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1852 Neighboring gene uncharacterized LOC107984760 Neighboring gene sprouty related EVH1 domain containing 1 Neighboring gene CTD small phosphatase 2 pseudogene Neighboring gene uncharacterized LOC105370774 Neighboring gene RAS guanyl releasing protein 1 Neighboring gene uncharacterized LOC107984739

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of atypical psychosis.
GeneReviews: Not available
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, family with sequence similarity 98, member B (FAM98B), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with FAM98B is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38426

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of tRNA-splicing ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of tRNA-splicing ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173611.4NP_775882.2  protein FAM98B

    Status: VALIDATED

    Source sequence(s)
    AI638256, BC035600, BC045690, BP872319, BU633364, BX454964, DA118586, DA520319, DB552059
    Consensus CDS
    CCDS10047.2
    UniProtKB/Swiss-Prot
    Q52LJ0
    Related
    ENSP00000380734.2, ENST00000397609.6
    Conserved Domains (1) summary
    pfam10239
    Location:17330
    DUF2465; Protein of unknown function (DUF2465)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    38454127..38487710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001042429.1: Suppressed sequence

    Description
    NM_001042429.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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