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EWSAT1 Ewing sarcoma associated transcript 1 [ Homo sapiens (human) ]

Gene ID: 283673, updated on 17-Sep-2024

Summary

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Official Symbol
EWSAT1provided by HGNC
Official Full Name
Ewing sarcoma associated transcript 1provided by HGNC
Primary source
HGNC:HGNC:26596
See related
Ensembl:ENSG00000212766 MIM:616492; AllianceGenome:HGNC:26596
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM84; LINC00277; NCRNA00277
Expression
Biased expression in testis (RPKM 2.1), kidney (RPKM 0.6) and 4 other tissues See more
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Genomic context

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See EWSAT1 in Genome Data Viewer
Location:
15q23
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (69080850..69095824)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (66903394..66918357)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (69373190..69388164)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene SPESP1-NOX5 readthrough Neighboring gene ATP binding cassette subfamily G member 2 (JR blood group) pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69318396-69318896 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:69328421-69329620 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:69341256-69341437 Neighboring gene NADPH oxidase 5 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:69352321-69352820 Neighboring gene uncharacterized LOC124903515 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:69378684-69379278 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69382031-69382532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:69385773-69386273 Neighboring gene uncharacterized LOC124903516 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:69408482-69409456 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:69409457-69410430 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:69412000-69412925 Neighboring gene Sharpr-MPRA regulatory region 1691 Neighboring gene NANOG hESC enhancer GRCh37_chr15:69431124-69431625 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69452636-69453136 Neighboring gene family with sequence similarity 47 member C pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6597 Neighboring gene glucuronic acid epimerase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LncRNA-EWSAT1 promotes hepatocellular carcinoma metastasis via activation of the Src-YAP signaling axis. He X, et al. FASEB J, 2022 Dec. PMID 36421017
  2. LncRNA EWSAT1 Regulates the Tumorigenesis of NSCLC as a ceRNA by Modulating miR-330-5p/ITGA5 Axis. Cui S, et al. Biochem Genet, 2021 Dec. PMID 33928467
  3. EWSAT1 Acts in Concert with Exosomes in Osteosarcoma Progression and Tumor-Induced Angiogenesis: The "Double Stacking Effect". Tao SC, et al. Adv Biosyst, 2020 Sep. PMID 32803878
  4. Increased EWSAT1 expression promotes cell proliferation, invasion and epithelial-mesenchymal transition in colorectal cancer. Zhang R, et al. Eur Rev Med Pharmacol Sci, 2018 Oct. PMID 30402843
  5. LncRNA EWSAT1 promotes ovarian cancer progression through targeting miR-330-5p expression. Fu X, et al. Am J Transl Res, 2017. PMID 28979684, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA-EWSAT1 promotes hepatocellular carcinoma metastasis via activation of the Src-YAP signaling axis.
    Title: LncRNA-EWSAT1 promotes hepatocellular carcinoma metastasis via activation of the Src-YAP signaling axis.
  2. LncRNA EWSAT1 Regulates the Tumorigenesis of NSCLC as a ceRNA by Modulating miR-330-5p/ITGA5 Axis.
    Title: LncRNA EWSAT1 Regulates the Tumorigenesis of NSCLC as a ceRNA by Modulating miR-330-5p/ITGA5 Axis.
  3. EWSAT1 Acts in Concert with Exosomes in Osteosarcoma Progression and Tumor-Induced Angiogenesis: The ""Double Stacking Effect"".
    Title: EWSAT1 Acts in Concert with Exosomes in Osteosarcoma Progression and Tumor-Induced Angiogenesis: The "Double Stacking Effect".
  4. LncRNA EWSAT1 upregulates CPEB4 via miR-330-5p to promote cervical cancer development.
    Title: LncRNA EWSAT1 upregulates CPEB4 via miR-330-5p to promote cervical cancer development.
  5. Increased EWSAT1 expression promotes cell proliferation, invasion and epithelial-mesenchymal transition in colorectal cancer cells.
    Title: Increased EWSAT1 expression promotes cell proliferation, invasion and epithelial-mesenchymal transition in colorectal cancer.
  6. HPV-positive cervical neoplasia patients exhibit significantly reduced LINC01101 and LINC00277 expression levels.
    Title: LINC01101 and LINC00277 expression levels as novel factors in HPV-induced cervical neoplasia.
  7. Collectively, our data revealed that EWSAT1 promotes nasopharyngeal carcinoma cell growth in vitro through up-regulating cyclin D1 partially via 'spongeing' miR-326/330-5p clusters.
    Title: Long non-coding RNA EWSAT1 promotes human nasopharyngeal carcinoma cell growth in vitro by targeting miR-326/-330-5p.
  8. EWSAT1 promotes osteosarcoma cell growth and metastasis through suppression of MEG3 expression.
    Title: Long Noncoding RNA EWSAT1 Promotes Osteosarcoma Cell Growth and Metastasis Through Suppression of MEG3 Expression.
  9. data reveal that EWSAT1 is a downstream target of EWS-FLI1 that facilitates the development of Ewing sarcoma via the repression of target genes.
    Title: Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • long intergenic non-protein coding RNA 277
  • testicular tissue protein Li 207
  • transmembrane protein 84

Clone Names

  • FLJ33768, MGC126643, MGC126645

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_026949.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA843716, AC027088, AK091087, BX493526
    Related
    ENST00000440444.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    69080850..69095824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    66903394..66918357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173610.1: Suppressed sequence

    Description
    NM_173610.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version

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