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DNA Cell Biol. 2016 Dec;35(12):812-818. Epub 2016 Nov 18.

Long Noncoding RNA EWSAT1 Promotes Osteosarcoma Cell Growth and Metastasis Through Suppression of MEG3 Expression.

Author information

1
1 Department of Orthopedics, Cangzhou Central Hospital , Hebei, China .
2
2 Department of Ultrasound, Cangzhou Central Hospital , Hebei, China .
3
3 Department of Endocrinology, Cangzhou Central Hospital , Hebei, China .

Abstract

Osteosarcoma (OS) is the most common primary bone tumor in children and adolescents. Long noncoding RNAs (lncRNAs) are a class of transcriptional products of the genome without protein-coding potential. Recently, lncRNA Ewing sarcoma-associated transcript 1 (EWSAT1) was functionally identified in Ewing sarcoma, a highly aggressive primary pediatric bone tumor. However, whether EWSAT1 plays a role in OS remains unclear. In the present study, gain- and loss-of-function assays demonstrated that EWSAT1 enhanced OS cell proliferation, migration, and invasion. Further mechanistic studies found that EWSAT1 positively regulated lncRNA MEG3 expression in the transcriptional level. Finally, we observed that EWSAT1 facilitates OS cell growth and metastasis through regulation of MEG3, suggesting that EWSAT1-MEG3 axis might be a promising target for OS treatment.

KEYWORDS:

EWSAT1; MEG3; lncRNA; metastasis

PMID:
27860482
DOI:
10.1089/dna.2016.3467
[Indexed for MEDLINE]

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