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PRTG protogenin [ Homo sapiens (human) ]

Gene ID: 283659, updated on 19-Sep-2021

Summary

Official Symbol
PRTGprovided by HGNC
Official Full Name
protogeninprovided by HGNC
Primary source
HGNC:HGNC:26373
See related
Ensembl:ENSG00000166450 MIM:613261
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IGDCC5
Summary
This gene encodes a member of the immunoglobulin superfamily. The encoded transmembrane protein has been associated with the development of various tissues, especially neurogenesis. It has been suggested that this gene may be associated with attention deficit hyperactivity disorder (ADHD). [provided by RefSeq, Nov 2014]
Expression
Biased expression in thyroid (RPKM 4.7), endometrium (RPKM 1.7) and 7 other tissues See more
Orthologs
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Genomic context

See PRTG in Genome Data Viewer
Location:
15q21.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (55611540..55743152, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (55903742..56035350, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene DNAAF4-CCPG1 readthrough (NMD candidate) Neighboring gene thioesterase superfamily member 4 pseudogene Neighboring gene dynein axonemal assembly factor 4 Neighboring gene pygopus family PHD finger 1 Neighboring gene NEDD4 intron nontranscribed DNase I hypersensitive site-defined enhancer Neighboring gene NEDD4 E3 ubiquitin protein ligase Neighboring gene CNOT6L pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12795, FLJ13221, FLJ25756

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protogenin
Names
immunoglobulin superfamily, DCC subclass, member 5
protogenin homolog (Gallus gallus)
shen-dan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173814.6NP_776175.2  protogenin precursor

    See identical proteins and their annotated locations for NP_776175.2

    Status: REVIEWED

    Source sequence(s)
    AC009997, AC012378, AK022857, AK023283, AY630258, BQ215513, CN283887, CN352629, CN352630, CN360440, CN360445, CN369786, CN369787, CN371161, CN371162, CN371165, CN371167, DA732429, DA737881
    Consensus CDS
    CCDS42040.1
    UniProtKB/Swiss-Prot
    Q2VWP7
    Related
    ENSP00000373937.4, ENST00000389286.9
    Conserved Domains (6) summary
    smart00408
    Location:250309
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:141223
    IG_like; Immunoglobulin like
    cd00063
    Location:821911
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:327412
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:624699
    fn3; Fibronectin type III domain
    cl11960
    Location:40130
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    55611540..55743152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022081.2XP_016877570.1  protogenin isoform X1

  2. XM_017022082.2XP_016877571.1  protogenin isoform X2

  3. XM_011521460.2XP_011519762.1  protogenin isoform X4

    Conserved Domains (5) summary
    smart00408
    Location:250309
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:141223
    IG_like; Immunoglobulin like
    cd00063
    Location:419512
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:327412
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:40130
    Ig; Immunoglobulin domain
  4. XM_011521459.2XP_011519761.1  protogenin isoform X3

    Conserved Domains (5) summary
    smart00408
    Location:250309
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:141223
    IG_like; Immunoglobulin like
    cd00063
    Location:419512
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:327412
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:40130
    Ig; Immunoglobulin domain
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