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MAJIN membrane anchored junction protein [ Homo sapiens (human) ]

Gene ID: 283129, updated on 23-Nov-2021

Summary

Official Symbol
MAJINprovided by HGNC
Official Full Name
membrane anchored junction proteinprovided by HGNC
Primary source
HGNC:HGNC:27441
See related
Ensembl:ENSG00000168070 MIM:617130
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C11orf85
Expression
Restricted expression toward testis (RPKM 5.4) See more
Orthologs
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Genomic context

See MAJIN in Genome Data Viewer
Location:
11q13.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (64938230..64972108, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64705702..64739580, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene autophagy related 2A Neighboring gene microRNA 6749 Neighboring gene protein phosphatase 2 regulatory subunit B'beta Neighboring gene glycoprotein hormone subunit alpha 2 Neighboring gene CRISPRi-validated cis-regulatory element chr11.3163 Neighboring gene basic leucine zipper ATF-like transcription factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126364

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in homologous chromosome pairing at meiosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in meiotic attachment of telomere to nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in meiotic attachment of telomere to nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in meiotic telomere clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in chromosome, telomeric region ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in integral component of nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of nuclear inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
membrane-anchored junction protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037225.3NP_001032302.1  membrane-anchored junction protein isoform 1

    See identical proteins and their annotated locations for NP_001032302.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AP000436, BC033501, BC106951, DB445650, HY050994
    Consensus CDS
    CCDS31603.1
    UniProtKB/Swiss-Prot
    Q3KP22
    Related
    ENSP00000301896.5, ENST00000301896.6
    Conserved Domains (1) summary
    pfam15077
    Location:1216
    MAJIN; Membrane-anchored junction protein
  2. NM_001300803.2NP_001287732.1  membrane-anchored junction protein isoform 2

    See identical proteins and their annotated locations for NP_001287732.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment and contains an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (2) lacks an alternate internal segment and has a longer and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AP000436, BC033501, DB445650
    Consensus CDS
    CCDS73316.1
    UniProtKB/Swiss-Prot
    Q3KP22
    Related
    ENSP00000434568.1, ENST00000530444.5
    Conserved Domains (1) summary
    pfam15077
    Location:1159
    MAJIN; Membrane-anchored junction protein
  3. NM_001318808.2NP_001305737.1  membrane-anchored junction protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction and lacks an alternate coding exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK093130, AP000436, AW449463, DB445650
    UniProtKB/Swiss-Prot
    Q3KP22
    Conserved Domains (1) summary
    pfam15077
    Location:1131
    MAJIN; Membrane-anchored junction protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    64938230..64972108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448447.1XP_024304215.1  membrane-anchored junction protein isoform X1

    Conserved Domains (1) summary
    pfam15077
    Location:1237
    MAJIN; Membrane-anchored junction protein
  2. XM_005273918.2XP_005273975.1  membrane-anchored junction protein isoform X1

    See identical proteins and their annotated locations for XP_005273975.1

    Conserved Domains (1) summary
    pfam15077
    Location:1237
    MAJIN; Membrane-anchored junction protein
  3. XM_024448448.1XP_024304216.1  membrane-anchored junction protein isoform X2

    Conserved Domains (1) summary
    pfam15077
    Location:1131
    MAJIN; Membrane-anchored junction protein
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