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ANG angiogenin [ Homo sapiens (human) ]

Gene ID: 283, updated on 24-Nov-2020

Summary

Official Symbol
ANGprovided by HGNC
Official Full Name
angiogeninprovided by HGNC
Primary source
HGNC:HGNC:483
See related
Ensembl:ENSG00000214274 MIM:105850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALS9; RAA1; HEL168; RNASE4; RNASE5
Summary
The protein encoded by this gene is a member of the RNase A superfamily though it has relatively weak ribonucleolytic activity. This protein is a potent mediator of new blood vessel formation and thus, in addition to the name RNase5, is commonly called angiogenin. This protein induces angiogenesis after binding to actin on the surface of endothelial cells. This protein also accumulates at the nucleolus where it stimulates ribosomal transcription. Under stress conditions this protein translocates to the cytosol where it hydrolyzes cellular tRNAs and influences protein synthesis. A signal peptide is cleaved from the precursor protein to produce a mature protein which contains a nuclear localization signal, a cell binding motif, and a catalytic domain. This protein has been shown to be both neurotrophic and neuroprotective and the mature protein has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Due to its effect on rRNA production and angiogenesis this gene plays important roles in cell growth and tumor progression. Mutations in this gene are associated with progression of amyotrophic lateral sclerosis (ALS). This gene and the neighboring RNase4 gene share promoters and 5' exons though each gene then splices to a distinct 3' exon containing the complete coding region of each gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2020]
Expression
Biased expression in liver (RPKM 449.5), ovary (RPKM 29.5) and 2 other tissues See more
Orthologs

Genomic context

See ANG in Genome Data Viewer
Location:
14q11.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (20684177..20694186)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21152336..21162345)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene tRNA-Tyr (anticodon GTA) 5-5 Neighboring gene tRNA-Pro (anticodon TGG) 3-2 Neighboring gene ribonuclease A family member 4 Neighboring gene uncharacterized LOC107984671 Neighboring gene RAN binding protein 20 pseudogene Neighboring gene epididymal protein 3A Neighboring gene epididymal protein 3D, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infected clinical samples have plasma extracellular vesicles that contain elevated CCL1 (I309), IGFBP1, CCL5 (RANTES), GMCSF, ANG (Angiogenin), ADIPOQ (ACRP30), CSF3 (GCSF), CXCL1, ICAM1, IL2RA, IL6R, TNFRSF1A, and TIMP1 compared to healthy donors PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC22466, MGC71966

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IC
Inferred by Curator
more info
PubMed 
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
copper ion binding IDA
Inferred from Direct Assay
more info
PubMed 
endonuclease activity TAS
Traceable Author Statement
more info
PubMed 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
peptide binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
rRNA binding TAS
Traceable Author Statement
more info
PubMed 
ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of phospholipase A2 activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of phospholipase C activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of protein kinase B activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
adherens junction organization TAS
Traceable Author Statement
more info
 
angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis TAS
Traceable Author Statement
more info
PubMed 
antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell communication NAS
Non-traceable Author Statement
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
diacylglycerol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
homeostatic process NAS
Non-traceable Author Statement
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of translation IEA
Inferred from Electronic Annotation
more info
 
oocyte maturation NAS
Non-traceable Author Statement
more info
PubMed 
ovarian follicle development NAS
Non-traceable Author Statement
more info
PubMed 
placenta development NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
rRNA transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hormone IDA
Inferred from Direct Assay
more info
PubMed 
response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
response to hypoxia NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
angiogenin-PRI complex IDA
Inferred from Direct Assay
more info
PubMed 
angiogenin-PRI complex IPI
Inferred from Physical Interaction
more info
PubMed 
basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
angiogenin
Names
RNase 5
angiogenin, ribonuclease, RNase A family, 5
epididymis luminal protein 168
ribonuclease 5
ribonuclease A A1
ribonuclease A family member 5
NP_001091046.1
NP_001136.1
NP_001372200.1
NP_001372201.1
NP_001372202.1
NP_001372203.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008717.2 RefSeqGene

    Range
    5001..15010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_653

mRNA and Protein(s)

  1. NM_001097577.3NP_001091046.1  angiogenin precursor

    See identical proteins and their annotated locations for NP_001091046.1

    Status: REVIEWED

    Source sequence(s)
    AL163636
    Consensus CDS
    CCDS9554.1
    UniProtKB/Swiss-Prot
    P03950
    UniProtKB/TrEMBL
    W0UV28
    Related
    ENSP00000381077.4, ENST00000397990.4
    Conserved Domains (1) summary
    smart00092
    Location:26143
    RNAse_Pc; Pancreatic ribonuclease
  2. NM_001145.4NP_001136.1  angiogenin precursor

    See identical proteins and their annotated locations for NP_001136.1

    Status: REVIEWED

    Source sequence(s)
    AL163636
    Consensus CDS
    CCDS9554.1
    UniProtKB/Swiss-Prot
    P03950
    UniProtKB/TrEMBL
    W0UV28
    Related
    ENSP00000336762.6, ENST00000336811.10
    Conserved Domains (1) summary
    smart00092
    Location:26143
    RNAse_Pc; Pancreatic ribonuclease
  3. NM_001385271.1NP_001372200.1  angiogenin precursor

    Status: REVIEWED

    Source sequence(s)
    AL163636
  4. NM_001385272.1NP_001372201.1  angiogenin precursor

    Status: REVIEWED

    Source sequence(s)
    AL163636
  5. NM_001385273.1NP_001372202.1  angiogenin precursor

    Status: REVIEWED

    Source sequence(s)
    AL163636
  6. NM_001385274.1NP_001372203.1  angiogenin precursor

    Status: REVIEWED

    Source sequence(s)
    AL163636

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    20684177..20694186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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