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CMKLR2 chemerin chemokine-like receptor 2 [ Homo sapiens (human) ]

Gene ID: 2825, updated on 26-Oct-2022

Summary

Official Symbol
CMKLR2provided by HGNC
Official Full Name
chemerin chemokine-like receptor 2provided by HGNC
Primary source
HGNC:HGNC:4463
See related
Ensembl:ENSG00000183671 MIM:600239; AllianceGenome:HGNC:4463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR1
Summary
Enables adipokinetic hormone binding activity and adipokinetic hormone receptor activity. Predicted to be involved in glucose homeostasis and neuropeptide signaling pathway. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta (RPKM 1.8), esophagus (RPKM 1.0) and 14 other tissues See more
Orthologs
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Genomic context

See CMKLR2 in Genome Data Viewer
Location:
2q33.3
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (206175316..206217912, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (206657211..206699815, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (207040040..207082636, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 beta 2 Neighboring gene small nucleolar RNA, C/D box 51 Neighboring gene small nucleolar RNA, H/ACA box 41 Neighboring gene CMKLR2 antisense RNA Neighboring gene RN7SK pseudogene 200 Neighboring gene ATP5PO pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Mesangial cells, an important component of the glomerulus, are susceptible to HIV-1 strains for which the viral gp120 protein uses GPR1 as a coreceptor PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adipokinetic hormone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables adipokinetic hormone receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
chemerin-like receptor 2
Names
G protein-coupled receptor 1
chemokine-like receptor 2
probable G-protein coupled receptor 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098199.2NP_001091669.1  chemerin-like receptor 2

    See identical proteins and their annotated locations for NP_001091669.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    BC067833, BX094581, BX389743, DA692381, DA988428
    Consensus CDS
    CCDS2368.1
    UniProtKB/Swiss-Prot
    P46091, Q6NVX4
    Conserved Domains (1) summary
    cd15119
    Location:39315
    7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001261452.2NP_001248381.1  chemerin-like receptor 2

    See identical proteins and their annotated locations for NP_001248381.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AK312917, BC067833, DA988428, EF577403
    Consensus CDS
    CCDS2368.1
    UniProtKB/Swiss-Prot
    P46091, Q6NVX4
    Related
    ENSP00000397535.1, ENST00000437420.5
    Conserved Domains (1) summary
    cd15119
    Location:39315
    7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001261453.2NP_001248382.1  chemerin-like receptor 2

    See identical proteins and their annotated locations for NP_001248382.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    BC067833, DA545892, DA988428, EF577403
    Consensus CDS
    CCDS2368.1
    UniProtKB/Swiss-Prot
    P46091, Q6NVX4
    Conserved Domains (1) summary
    cd15119
    Location:39315
    7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_001261454.1NP_001248383.1  chemerin-like receptor 2

    See identical proteins and their annotated locations for NP_001248383.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    BC067833, BP279126, EF577403
    Consensus CDS
    CCDS2368.1
    UniProtKB/Swiss-Prot
    P46091, Q6NVX4
    Conserved Domains (1) summary
    cd15119
    Location:39315
    7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. NM_001261455.1NP_001248384.1  chemerin-like receptor 2

    See identical proteins and their annotated locations for NP_001248384.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AK312917, BC067833, BP279126, DA733626, EF577403
    Consensus CDS
    CCDS2368.1
    UniProtKB/Swiss-Prot
    P46091, Q6NVX4
    Conserved Domains (1) summary
    cd15119
    Location:39315
    7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors
  6. NM_001389445.1NP_001376374.1  chemerin-like receptor 2

    Status: VALIDATED

    Source sequence(s)
    AC007383, AK075130
    Consensus CDS
    CCDS2368.1
    UniProtKB/Swiss-Prot
    Q6NVX4
    Related
    ENSP00000483003.1, ENST00000621141.5
    Conserved Domains (1) summary
    cd15119
    Location:39315
    7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors
  7. NM_005279.4NP_005270.2  chemerin-like receptor 2

    See identical proteins and their annotated locations for NP_005270.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and all other variants encode the same protein.
    Source sequence(s)
    BC067833, BX094581, BX389743, DA692381, DA988428
    Consensus CDS
    CCDS2368.1
    UniProtKB/Swiss-Prot
    P46091, Q6NVX4
    Related
    ENSP00000384345.2, ENST00000407325.6
    Conserved Domains (1) summary
    cd15119
    Location:39315
    7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    206175316..206217912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443968.1XP_047299924.1  chemerin-like receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6NVX4

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_015495299.1 Reference GRCh38.p14 PATCHES

    Range
    284334..326930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    206657211..206699815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)