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Agpat3 1-acylglycerol-3-phosphate O-acyltransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 28169, updated on 2-Nov-2024

Summary

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Official Symbol
Agpat3provided by MGI
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 3provided by MGI
Primary source
MGI:MGI:1336186
See related
Ensembl:ENSMUSG00000001211 AllianceGenome:MGI:1336186
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
lpaat3; D10Jhu12e
Summary
Enables lysophosphatidic acid acyltransferase activity. Predicted to be involved in CDP-diacylglycerol biosynthetic process. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 65.3), adrenal adult (RPKM 53.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Agpat3 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (78105008..78188335, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (78269174..78352497, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27217 Neighboring gene trafficking protein particle complex 10 Neighboring gene STARR-seq mESC enhancer starr_27219 Neighboring gene predicted gene, 30122 Neighboring gene STARR-positive B cell enhancer ABC_E3894 Neighboring gene STARR-seq mESC enhancer starr_27222 Neighboring gene microRNA 7659 Neighboring gene predicted gene, 40709 Neighboring gene LSM7 homolog, U6 small nuclear RNA associated pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. AGPAT3 deficiency impairs adipocyte differentiation and leads to a lean phenotype in mice. Zhou H, et al. Am J Physiol Endocrinol Metab, 2024 Jul 1. PMID 38717361,
  2. Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3. Koeberle A, et al. FASEB J, 2012 Jan. PMID 21968070
  3. Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis. Iizuka-Hishikawa Y, et al. J Biol Chem, 2017 Jul 21. PMID 28578315, Free PMC Article
  4. Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells. Shindou H, et al. J Biol Chem, 2017 Jul 21. PMID 28578316, Free PMC Article
  5. LPAAT3 incorporates docosahexaenoic acid into skeletal muscle cell membranes and is upregulated by PPARδ activation. Valentine WJ, et al. J Lipid Res, 2018 Feb. PMID 29284664, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AGPAT3 deficiency impairs adipocyte differentiation and leads to a lean phenotype in mice.
    Title: AGPAT3 deficiency impairs adipocyte differentiation and leads to a lean phenotype in mice.
  2. A loss of function variant in AGPAT3 underlies intellectual disability and retinitis pigmentosa (IDRP) syndrome.
    Title: A loss of function variant in AGPAT3 underlies intellectual disability and retinitis pigmentosa (IDRP) syndrome.
  3. It identified lysophosphatidic acid acyltransferase (LPAAT)3 as an enzyme that was upregulated in myoblasts during in vitro differentiation and selectively incorporated DHA intophosphatidylcholine and phosphatidylethanolamine.
    Title: LPAAT3 incorporates docosahexaenoic acid into skeletal muscle cell membranes and is upregulated by PPARδ activation.
  4. Data suggest that LPAAT3 is required for producing docosahexaenoic acid- (DHA)-containing phospholipids in various tissues, such as the testes and retina; LPAAT3-knockout mice exhibit severe male infertility with abnormal sperm morphology; lack of LPAAT3 causes drastic reduction of DHA-containing phospholipids in spermatids with excess cytoplasm around the sperm head.
    Title: Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis.
  5. Data suggest that PL-DHA (docosahexaenoic acid-containing phospholipids) contribute to visual function by maintaining disc shape in photoreceptor cells; PL-DHA disappears from outer segment in LPAAT3-knockout mice; LPAAT3-knockout mice exhibit abnormalities in retinal layers, disordered disc morphology in photoreceptor cells, and impaired visual function.
    Title: Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells.
  6. The induction of LPAAT3 during germ cell development critically contributes to the accumulation of PUFAs in testicular phospholipids, thereby possibly affecting sperm cell production.
    Title: Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3.
  7. mAGPAT 1, 2, and 3 mRNA levels increased rapidly in mouse skin after acute permeability barrier disruption
    Title: Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate acyltransferases in the epidermis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lysophosphatidic acid acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
Names
1-AGP acyltransferase 3
1-AGPAT 3
LPAAT-gamma
lysophosphatidic acid acyltransferase 3
lysophosphatidic acid acyltransferase gamma
NP_001391799.1
NP_001391800.1
NP_001391801.1
NP_001391802.1
NP_001391803.1
NP_001391804.1
NP_001391805.1
NP_001391806.1
NP_001391807.1
NP_001391808.1
NP_001391809.1
NP_001391810.1
NP_001391811.1
NP_443747.2
XP_006513781.1
XP_036011691.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404870.1 → NP_001391799.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a

    Status: VALIDATED

    Source sequence(s)
    AC160405
    UniProtKB/Swiss-Prot
    C4B4E7, Q7TT39, Q8BST2, Q9D517

  2. NM_001404871.1 → NP_001391800.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a

    Status: VALIDATED

    Source sequence(s)
    AC160405
    UniProtKB/Swiss-Prot
    C4B4E7, Q7TT39, Q8BST2, Q9D517

  3. NM_001404872.1 → NP_001391801.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a

    Status: VALIDATED

    Source sequence(s)
    AC160405
    UniProtKB/Swiss-Prot
    C4B4E7, Q7TT39, Q8BST2, Q9D517
    Related
    ENSMUSP00000101026.2, ENSMUST00000105387.8

  4. NM_001404873.1 → NP_001391802.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a

    Status: VALIDATED

    Source sequence(s)
    AC160405
    UniProtKB/Swiss-Prot
    C4B4E7, Q7TT39, Q8BST2, Q9D517

  5. NM_001404874.1 → NP_001391803.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a

    Status: VALIDATED

    Source sequence(s)
    AC160405
    UniProtKB/Swiss-Prot
    C4B4E7, Q7TT39, Q8BST2, Q9D517
    Related
    ENSMUSP00000101028.2, ENSMUST00000105389.8

  6. NM_001404875.1 → NP_001391804.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a

    Status: VALIDATED

    Source sequence(s)
    AC160405, AC160411
    UniProtKB/Swiss-Prot
    C4B4E7, Q7TT39, Q8BST2, Q9D517
    Related
    ENSMUSP00000001240.6, ENSMUST00000001240.12

  7. NM_001404876.1 → NP_001391805.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a

    Status: VALIDATED

    Source sequence(s)
    AC160405, AC160411
    UniProtKB/Swiss-Prot
    C4B4E7, Q7TT39, Q8BST2, Q9D517

  8. NM_001404877.1 → NP_001391806.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a

    Status: VALIDATED

    Source sequence(s)
    AC160405
    UniProtKB/Swiss-Prot
    C4B4E7, Q7TT39, Q8BST2, Q9D517

  9. NM_001404878.1 → NP_001391807.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform b

    Status: VALIDATED

    Source sequence(s)
    AC160405, AC160411

  10. NM_001404879.1 → NP_001391808.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform b

    Status: VALIDATED

    Source sequence(s)
    AC160405

  11. NM_001404880.1 → NP_001391809.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform b

    Status: VALIDATED

    Source sequence(s)
    AC160405

  12. NM_001404881.1 → NP_001391810.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform c

    Status: VALIDATED

    Source sequence(s)
    AC160405

  13. NM_001404882.1 → NP_001391811.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform d

    Status: VALIDATED

    Source sequence(s)
    AC160405

  14. NM_053014.4 → NP_443747.2  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform a

    See identical proteins and their annotated locations for NP_443747.2

    Status: VALIDATED

    Source sequence(s)
    AC160405, AC160411
    Consensus CDS
    CCDS23963.1
    UniProtKB/Swiss-Prot
    C4B4E7, Q7TT39, Q8BST2, Q9D517
    UniProtKB/TrEMBL
    Q3TXT9
    Conserved Domains (1) summary
    PLN02380
    Location:12 → 325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    78105008..78188335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513718.1 → XP_006513781.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    See identical proteins and their annotated locations for XP_006513781.1

    UniProtKB/Swiss-Prot
    C4B4E7, Q7TT39, Q8BST2, Q9D517
    UniProtKB/TrEMBL
    Q3TXT9
    Related
    ENSMUSP00000101029.2, ENSMUST00000105390.8
    Conserved Domains (1) summary
    PLN02380
    Location:12 → 325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

  2. XM_036155798.1 → XP_036011691.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    UniProtKB/Swiss-Prot
    C4B4E7, Q7TT39, Q8BST2, Q9D517
    UniProtKB/TrEMBL
    Q3TXT9
    Conserved Domains (1) summary
    PLN02380
    Location:12 → 325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D517.2 GenPept UniProtKB/Swiss-Prot:Q9D517

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