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AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 56894, updated on 12-Dec-2023

Summary

Official Symbol
AGPAT3provided by HGNC
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:326
See related
Ensembl:ENSG00000160216 MIM:614794; AllianceGenome:HGNC:326
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPAAT3; LPLAT3; 1-AGPAT 3; LPAAT-GAMMA1
Summary
The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 24.0), brain (RPKM 12.1) and 25 other tissues See more
Orthologs
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Genomic context

See AGPAT3 in Genome Data Viewer
Location:
21q22.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (43865223..43987592)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (42220581..42343213)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (45285104..45407473)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905033 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45269891-45270437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18552 Neighboring gene CRISPRi-validated cis-regulatory element chr21.1179 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13371 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13373 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:45299777-45299961 Neighboring gene MYL6 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45302099-45302685 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45305625-45306210 Neighboring gene uncharacterized LOC124905034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45328253-45328754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45336568-45337118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45337119-45337668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45339493-45340392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45340393-45341290 Neighboring gene Sharpr-MPRA regulatory region 2423 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45342191-45343088 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45344887-45345786 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45345787-45346684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45351938-45352438 Neighboring gene RNA, U6 small nuclear 859, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45354036-45354854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45358304-45359204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45359205-45360103 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:45360643-45360814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45363715-45364558 Neighboring gene uncharacterized LOC105372826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45376043-45376543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45401087-45401848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45401849-45402610 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45402611-45403372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13375 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45405825-45406355 Neighboring gene uncharacterized LOC105372829 Neighboring gene RNA, U6 small nuclear 1150, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18561 Neighboring gene trafficking protein particle complex subunit 10 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:45452244-45452456 Neighboring gene H2A.Z histone pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC4604

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in phospholipid biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
Names
1-AGP acyltransferase 3
lysophosphatidic acid acyltransferase gamma
lysophosphatidic acid acyltransferase-gamma1
lysophospholipid acyltransferase 3
NP_001032642.1
NP_001356807.1
NP_001356809.1
NP_001356810.1
NP_064517.1
XP_005261217.1
XP_006724093.1
XP_006724094.1
XP_011527963.2
XP_011527965.2
XP_016883897.1
XP_016883900.1
XP_047296870.1
XP_047296871.1
XP_047296872.1
XP_047296873.1
XP_047296874.1
XP_047296875.1
XP_047296876.1
XP_047296877.1
XP_047296878.1
XP_047296879.1
XP_047296880.1
XP_047296881.1
XP_047296882.1
XP_047296883.1
XP_047296884.1
XP_047296885.1
XP_054180677.1
XP_054180678.1
XP_054180679.1
XP_054180680.1
XP_054180681.1
XP_054180682.1
XP_054180683.1
XP_054180684.1
XP_054180685.1
XP_054180686.1
XP_054180687.1
XP_054180688.1
XP_054180689.1
XP_054180690.1
XP_054180691.1
XP_054180692.1
XP_054180693.1
XP_054180694.1
XP_054180695.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037553.2NP_001032642.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1

    See identical proteins and their annotated locations for NP_001032642.1

    Status: REVIEWED

    Source sequence(s)
    AB001523, AP001054
    Consensus CDS
    CCDS13703.1
    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    Related
    ENSP00000381140.2, ENST00000398063.6
    Conserved Domains (1) summary
    PLN02380
    Location:17325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
  2. NM_001369878.1NP_001356807.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1

    Status: REVIEWED

    Source sequence(s)
    AB001523, AP001053, AP001054
    Consensus CDS
    CCDS13703.1
    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    Conserved Domains (1) summary
    PLN02380
    Location:17325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
  3. NM_001369880.1NP_001356809.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1

    Status: REVIEWED

    Source sequence(s)
    AB001523, AP001054
    Consensus CDS
    CCDS13703.1
    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    Conserved Domains (1) summary
    PLN02380
    Location:17325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
  4. NM_001369881.1NP_001356810.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB001523, AP001053, AP001054
    Conserved Domains (2) summary
    cd07990
    Location:1194
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:181252
    Acyltransf_C; Acyltransferase C-terminus
  5. NM_020132.5NP_064517.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform 1

    See identical proteins and their annotated locations for NP_064517.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AB001523, AP001053, AP001054, BC063552, CD672915
    Consensus CDS
    CCDS13703.1
    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    Related
    ENSP00000291572.8, ENST00000291572.13
    Conserved Domains (1) summary
    PLN02380
    Location:17325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    43865223..43987592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440922.1XP_047296878.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X8

  2. XM_047440916.1XP_047296872.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X2

  3. XM_047440921.1XP_047296877.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X8

  4. XM_047440915.1XP_047296871.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X2

  5. XM_047440923.1XP_047296879.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
  6. XM_006724031.4XP_006724094.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X6

    See identical proteins and their annotated locations for XP_006724094.1

    UniProtKB/Swiss-Prot
    Q9NRZ7
    Conserved Domains (2) summary
    cd07990
    Location:1194
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:181252
    Acyltransf_C; Acyltransferase C-terminus
  7. XM_047440926.1XP_047296882.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
  8. XM_005261160.5XP_005261217.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    See identical proteins and their annotated locations for XP_005261217.1

    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    Related
    ENSP00000381138.1, ENST00000398061.5
    Conserved Domains (1) summary
    PLN02380
    Location:17325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
  9. XM_047440924.1XP_047296880.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
  10. XM_047440925.1XP_047296881.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
  11. XM_017028408.2XP_016883897.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X7

  12. XM_047440920.1XP_047296876.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X5

  13. XM_047440928.1XP_047296884.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
  14. XM_011529663.3XP_011527965.2  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X6

  15. XM_047440917.1XP_047296873.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X3

  16. XM_047440918.1XP_047296874.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X4

  17. XM_047440914.1XP_047296870.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
  18. XM_047440919.1XP_047296875.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    Related
    ENSP00000381135.1, ENST00000398058.5
  19. XM_047440929.1XP_047296885.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X6

  20. XM_047440927.1XP_047296883.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
  21. XM_006724030.4XP_006724093.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    See identical proteins and their annotated locations for XP_006724093.1

    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
    Conserved Domains (1) summary
    PLN02380
    Location:17325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
  22. XM_011529661.3XP_011527963.2  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X6

  23. XM_017028411.2XP_016883900.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X6

    UniProtKB/Swiss-Prot
    Q9NRZ7
    Conserved Domains (2) summary
    cd07990
    Location:1194
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:181252
    Acyltransf_C; Acyltransferase C-terminus

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    42220581..42343213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324710.1XP_054180685.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X8

  2. XM_054324703.1XP_054180678.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X2

  3. XM_054324709.1XP_054180684.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X8

  4. XM_054324702.1XP_054180677.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X2

  5. XM_054324711.1XP_054180686.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
  6. XM_054324717.1XP_054180692.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X6

  7. XM_054324712.1XP_054180687.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
  8. XM_054324713.1XP_054180688.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
  9. XM_054324714.1XP_054180689.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
  10. XM_054324708.1XP_054180683.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X7

  11. XM_054324705.1XP_054180680.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X5

  12. XM_054324718.1XP_054180693.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
  13. XM_054324707.1XP_054180682.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X6

  14. XM_054324704.1XP_054180679.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X3

  15. XM_054324720.1XP_054180695.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X10

  16. XM_054324719.1XP_054180694.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X9

  17. XM_054324706.1XP_054180681.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X6

  18. XM_054324715.1XP_054180690.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    UniProtKB/Swiss-Prot
    D3DSL2, Q3ZCU2, Q6UWP6, Q6ZUC6, Q8N3Q7, Q9NRZ6, Q9NRZ7
  19. XM_054324716.1XP_054180691.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X6