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AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 56894, updated on 2-Oct-2018

Summary

Official Symbol
AGPAT3provided by HGNC
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:326
See related
Ensembl:ENSG00000160216 MIM:614794; Vega:OTTHUMG00000086892
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPAAT3; LPAAT-GAMMA1
Summary
The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 24.0), brain (RPKM 12.1) and 25 other tissues See more
Orthologs

Genomic context

See AGPAT3 in Genome Data Viewer
Location:
21q22.3
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 21 NC_000021.9 (43865160..43987594)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (45285116..45407475)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene apoptosis associated transcript in bladder cancer Neighboring gene myosin light chain 6 pseudogene 1 Neighboring gene RNA, U6 small nuclear 859, pseudogene Neighboring gene uncharacterized LOC105372826 Neighboring gene uncharacterized LOC105372829 Neighboring gene RNA, U6 small nuclear 1150, pseudogene Neighboring gene trafficking protein particle complex 10 Neighboring gene H2A histone family member Z pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4604

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-acylglycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
1-acylglycerol-3-phosphate O-acyltransferase activity NAS
Non-traceable Author Statement
more info
PubMed 
1-acylglycerol-3-phosphate O-acyltransferase activity TAS
Traceable Author Statement
more info
 
transferase activity, transferring acyl groups IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
phospholipid biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum HDA PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
plasma membrane HDA PubMed 

General protein information

Preferred Names
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
Names
1-AGP acyltransferase 3
1-AGPAT 3
lysophosphatidic acid acyltransferase gamma
lysophosphatidic acid acyltransferase-gamma1
NP_001032642.1
NP_064517.1
XP_005261217.1
XP_006724092.1
XP_006724093.1
XP_006724094.1
XP_011527962.1
XP_011527963.1
XP_011527964.1
XP_011527965.1
XP_011527966.1
XP_011527967.1
XP_016883897.1
XP_016883898.1
XP_016883899.1
XP_016883900.1
XP_016883901.1
XP_016883902.1
XP_016883903.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037553.1NP_001032642.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

    See identical proteins and their annotated locations for NP_001032642.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AB001523, AP001054, BC063552, BM083518
    Consensus CDS
    CCDS13703.1
    UniProtKB/Swiss-Prot
    Q9NRZ7
    Related
    ENSP00000381140.2, OTTHUMP00000109481, ENST00000398063.6, OTTHUMT00000195722
    Conserved Domains (1) summary
    PLN02380
    Location:17325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
  2. NM_020132.4NP_064517.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

    See identical proteins and their annotated locations for NP_064517.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AB001523, AP001054, BC063552, CD672915
    Consensus CDS
    CCDS13703.1
    UniProtKB/Swiss-Prot
    Q9NRZ7
    Related
    ENSP00000291572.8, OTTHUMP00000109478, ENST00000291572.12, OTTHUMT00000195719
    Conserved Domains (1) summary
    PLN02380
    Location:17325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p12 Primary Assembly

    Range
    43865160..43987594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724031.3XP_006724094.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X8

    See identical proteins and their annotated locations for XP_006724094.1

    UniProtKB/Swiss-Prot
    Q9NRZ7
    Conserved Domains (2) summary
    cd07990
    Location:1194
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:181252
    Acyltransf_C; Acyltransferase C-terminus
  2. XM_017028409.1XP_016883898.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X2

    UniProtKB/Swiss-Prot
    Q9NRZ7
    Conserved Domains (1) summary
    PLN02380
    Location:17325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
  3. XM_017028412.1XP_016883901.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X8

    UniProtKB/Swiss-Prot
    Q9NRZ7
    Conserved Domains (2) summary
    cd07990
    Location:1194
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:181252
    Acyltransf_C; Acyltransferase C-terminus
  4. XM_017028413.1XP_016883902.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X8

    UniProtKB/Swiss-Prot
    Q9NRZ7
    Conserved Domains (2) summary
    cd07990
    Location:1194
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:181252
    Acyltransf_C; Acyltransferase C-terminus
  5. XM_011529665.2XP_011527967.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X2

    See identical proteins and their annotated locations for XP_011527967.1

    UniProtKB/Swiss-Prot
    Q9NRZ7
    Conserved Domains (1) summary
    PLN02380
    Location:17325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
  6. XM_005261160.4XP_005261217.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X2

    See identical proteins and their annotated locations for XP_005261217.1

    UniProtKB/Swiss-Prot
    Q9NRZ7
    Related
    ENSP00000381138.1, OTTHUMP00000109479, ENST00000398061.5, OTTHUMT00000195720
    Conserved Domains (1) summary
    PLN02380
    Location:17325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
  7. XM_017028408.1XP_016883897.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X6

  8. XM_017028410.1XP_016883899.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X2

    UniProtKB/Swiss-Prot
    Q9NRZ7
    Conserved Domains (1) summary
    PLN02380
    Location:17325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
  9. XM_011529663.2XP_011527965.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X5

    Conserved Domains (3) summary
    cd07990
    Location:102296
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PLN02380
    Location:100365
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    pfam16076
    Location:283354
    Acyltransf_C; Acyltransferase C-terminus
  10. XM_006724029.3XP_006724092.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X2

    See identical proteins and their annotated locations for XP_006724092.1

    UniProtKB/Swiss-Prot
    Q9NRZ7
    Conserved Domains (1) summary
    PLN02380
    Location:17325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
  11. XM_017028414.1XP_016883903.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X9

  12. XM_011529661.2XP_011527963.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X3

    Conserved Domains (3) summary
    cd07990
    Location:136330
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PLN02380
    Location:134399
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    pfam16076
    Location:317388
    Acyltransf_C; Acyltransferase C-terminus
  13. XM_011529662.2XP_011527964.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X4

    Conserved Domains (3) summary
    cd07990
    Location:149343
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PLN02380
    Location:104412
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    pfam16076
    Location:330401
    Acyltransf_C; Acyltransferase C-terminus
  14. XM_006724030.3XP_006724093.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X2

    See identical proteins and their annotated locations for XP_006724093.1

    UniProtKB/Swiss-Prot
    Q9NRZ7
    Related
    ENSP00000381135.1, OTTHUMP00000109482, ENST00000398058.5, OTTHUMT00000195723
    Conserved Domains (1) summary
    PLN02380
    Location:17325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
  15. XM_011529664.2XP_011527966.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X7

    Conserved Domains (3) summary
    cd07990
    Location:66260
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PLN02380
    Location:64329
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    pfam16076
    Location:247318
    Acyltransf_C; Acyltransferase C-terminus
  16. XM_011529660.2XP_011527962.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    Conserved Domains (3) summary
    cd07990
    Location:44238
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PLN02380
    Location:42307
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    pfam16076
    Location:225296
    Acyltransf_C; Acyltransferase C-terminus
  17. XM_017028411.1XP_016883900.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X8

    UniProtKB/Swiss-Prot
    Q9NRZ7
    Conserved Domains (2) summary
    cd07990
    Location:1194
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:181252
    Acyltransf_C; Acyltransferase C-terminus
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