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GP5 glycoprotein V platelet [ Homo sapiens (human) ]

Gene ID: 2814, updated on 8-Jul-2021

Summary

Official Symbol
GP5provided by HGNC
Official Full Name
glycoprotein V plateletprovided by HGNC
Primary source
HGNC:HGNC:4443
See related
Ensembl:ENSG00000178732 MIM:173511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPV; CD42d
Summary
Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See GP5 in Genome Data Viewer
Location:
3q29
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (194394821..194399266, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (194115550..194119995, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene carboxypeptidase N subunit 2 Neighboring gene leucine rich repeat containing 15 Neighboring gene ATPase 13A3 Neighboring gene ATP13A3 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
platelet glycoprotein V
Names
glycoprotein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004488.2NP_004479.1  platelet glycoprotein V precursor

    See identical proteins and their annotated locations for NP_004479.1

    Status: VALIDATED

    Source sequence(s)
    AC125362
    Consensus CDS
    CCDS3307.1
    UniProtKB/Swiss-Prot
    P40197
    Related
    ENSP00000383931.1, ENST00000401815.1
    Conserved Domains (4) summary
    smart00082
    Location:421472
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:163400
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:100123
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:195254
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    194394821..194399266 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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