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Nsun2 NOL1/NOP2/Sun domain family member 2 [ Mus musculus (house mouse) ]

Gene ID: 28114, updated on 5-Feb-2023

Summary

Official Symbol
Nsun2provided by MGI
Official Full Name
NOL1/NOP2/Sun domain family member 2provided by MGI
Primary source
MGI:MGI:107252
See related
Ensembl:ENSMUSG00000021595 AllianceGenome:MGI:107252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Misu; D13Wsu123e
Summary
Enables mRNA (cytidine-5-)-methyltransferase activity and tRNA (cytosine-5-)-methyltransferase activity. Involved in several processes, including RNA methylation; meiotic cell cycle checkpoint signaling; and tRNA stabilization. Acts upstream of or within in utero embryonic development. Located in chromatoid body. Is expressed in several structures, including branchial arch; cardiovascular system; central nervous system; extraembryonic component; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human NSUN2 (NOP2/Sun RNA methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 24.0), testis adult (RPKM 23.5) and 28 other tissues See more
Orthologs
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Genomic context

See Nsun2 in Genome Data Viewer
Location:
13 B3; 13 35.55 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (69760135..69783899)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (69612016..69635780)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RAB geranylgeranyl transferase, b subunit pseudogene Neighboring gene steroid 5 alpha-reductase 1 Neighboring gene importin 7 pseudogene Neighboring gene predicted gene, 52059

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (5) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA (cytidine-5-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA (cytidine-5-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA (cytosine-5-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tRNA (cytosine-5-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables tRNA (cytosine-5-)-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables tRNA (cytosine-5-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA methylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hair follicle maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hair follicle maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in meiotic cell cycle checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tRNA methylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromatoid body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA cytosine C(5)-methyltransferase NSUN2
Names
Myc-induced SUN domain containing protein
NOL1/NOP2/Sun domain family 2
mRNA cytosine C(5)-methyltransferase
myc-induced SUN domain-containing protein
tRNA (cytosine(34)-C(5))-methyltransferase
tRNA (cytosine-5-)-methyltransferase NSUN2
tRNA cytosine C(5)-methyltransferase
NP_663329.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145354.5NP_663329.3  RNA cytosine C(5)-methyltransferase NSUN2

    See identical proteins and their annotated locations for NP_663329.3

    Status: VALIDATED

    Source sequence(s)
    AI787627, AK030124, BX630130, CJ092700
    Consensus CDS
    CCDS36722.2
    UniProtKB/Swiss-Prot
    Q1HFZ0, Q91YX9
    Related
    ENSMUSP00000105321.5, ENSMUST00000109699.11
    Conserved Domains (1) summary
    COG0144
    Location:28430
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    69760135..69783899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)