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PLoS Genet. 2011 Dec;7(12):e1002403. doi: 10.1371/journal.pgen.1002403. Epub 2011 Dec 1.

The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate.

Author information

1
Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, United Kingdom.

Abstract

Homeostasis of most adult tissues is maintained by balancing stem cell self-renewal and differentiation, but whether post-transcriptional mechanisms can regulate this process is unknown. Here, we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin. In the epidermis, this methyltransferase is found in a defined sub-population of hair follicle stem cells poised to undergo lineage commitment, and its depletion results in enhanced quiescence and aberrant stem cell differentiation. Our results reveal that post-transcriptional RNA methylation can play a previously unappreciated role in controlling stem cell fate.

PMID:
22144916
PMCID:
PMC3228827
DOI:
10.1371/journal.pgen.1002403
[Indexed for MEDLINE]
Free PMC Article

Conflict of interest statement

Misu is part of a current patent application.

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