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Tada1 transcriptional adaptor 1 [ Mus musculus (house mouse) ]

Gene ID: 27878, updated on 2-Nov-2024

Summary

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Official Symbol
Tada1provided by MGI
Official Full Name
transcriptional adaptor 1provided by MGI
Primary source
MGI:MGI:1196415
See related
Ensembl:ENSMUSG00000026563 AllianceGenome:MGI:1196415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Staf42; Tada1l; D1Ertd251e; 2900026B15Rik
Summary
Predicted to enable transcription coactivator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; focal adhesion; and nucleoplasm. Predicted to be part of SAGA complex. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and hemolymphoid system. Orthologous to human TADA1 (transcriptional adaptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 23.4), CNS E14 (RPKM 21.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tada1 in Genome Data Viewer
Location:
1 H2.3; 1 73.74 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (166206736..166221190)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (166379167..166393621)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02926 Neighboring gene maelstrom spermatogenic transposon silencer Neighboring gene immunoglobulin-like domain containing receptor 2 Neighboring gene STARR-positive B cell enhancer mm9_chr1:168290436-168290736 Neighboring gene STARR-seq mESC enhancer starr_02930 Neighboring gene STARR-positive B cell enhancer ABC_E11695 Neighboring gene pogo transposable element with KRAB domain Neighboring gene STARR-seq mESC enhancer starr_02931 Neighboring gene ubiquinol-cytochrome c reductase subunit pseudogene Neighboring gene predicted gene, 39694

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic and physical mapping of the dreher locus on mouse chromosome 1. Bergstrom DE, et al. Genomics, 1999 Aug 1. PMID 10444330
  2. The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes. Nagy Z, et al. Mol Cell Biol, 2009 Mar. PMID 19114550, Free PMC Article
  3. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Martinez E, et al. Mol Cell Biol, 2001 Oct. PMID 11564863, Free PMC Article
  4. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Zhao Y, et al. Mol Cell, 2008 Jan 18. PMID 18206972
  5. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SAGA complex ISO
Inferred from Sequence Orthology
more info
  
part_of SAGA complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcriptional adapter 1
Names
transcriptional adapter 1-like protein
transcriptional adaptor 1 (HFI1 homolog, yeast) like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030245.3 → NP_084521.1  transcriptional adapter 1

    See identical proteins and their annotated locations for NP_084521.1

    Status: VALIDATED

    Source sequence(s)
    AC161807, AK151132, BY057637, DV645054
    Consensus CDS
    CCDS15450.1
    UniProtKB/Swiss-Prot
    Q99LM9
    Related
    ENSMUSP00000027846.8, ENSMUST00000027846.8
    Conserved Domains (1) summary
    pfam12767
    Location:7 → 193
    SAGA-Tad1; Transcriptional regulator of RNA polII, SAGA, subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    166206736..166221190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254784.2 → XP_030110644.1  transcriptional adapter 1 isoform X1

    Conserved Domains (1) summary
    pfam12767
    Location:2 → 51
    SAGA-Tad1; Transcriptional regulator of RNA polII, SAGA, subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LM9.1 GenPept UniProtKB/Swiss-Prot:Q99LM9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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