Format

Send to:

Choose Destination

GNB2 G protein subunit beta 2 [ Homo sapiens (human) ]

Gene ID: 2783, updated on 7-Jun-2020

Summary

Official Symbol
GNB2provided by HGNC
Official Full Name
G protein subunit beta 2provided by HGNC
Primary source
HGNC:HGNC:4398
See related
Ensembl:ENSG00000172354 MIM:139390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 67.4), prostate (RPKM 65.4) and 25 other tissues See more
Orthologs

Genomic context

See GNB2 in Genome Data Viewer
Location:
7q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100673740..100679169)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100271363..100276792)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene actin like 6B Neighboring gene uncharacterized LOC105375429 Neighboring gene GRB10 interacting GYF protein 1 Neighboring gene CRISPRi-validated cis-regulatory element chr7.3567 Neighboring gene POP7 homolog, ribonuclease P/MRP subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein gamma-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity TAS
Traceable Author Statement
more info
PubMed 
GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium channel regulator activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein folding TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell body IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
focal adhesion HDA PubMed 
heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosomal membrane HDA PubMed 
membrane HDA PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
vesicle HDA PubMed 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Names
G protein, beta-2 subunit
epididymis secretory sperm binding protein
g protein subunit beta-2
guanine nucleotide binding protein (G protein), beta polypeptide 2
guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 2
signal-transducing guanine nucleotide-binding regulatory protein beta subunit
transducin beta chain 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005273.4NP_005264.2  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

    See identical proteins and their annotated locations for NP_005264.2

    Status: REVIEWED

    Source sequence(s)
    AK291592, AL535249, BC012348, BM763069, CV569909
    Consensus CDS
    CCDS5703.1
    UniProtKB/Swiss-Prot
    P62879
    UniProtKB/TrEMBL
    Q6FHM2
    Related
    ENSP00000305260.4, ENST00000303210.9
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100673740..100679169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center