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Gnb2 guanine nucleotide binding protein (G protein), beta 2 [ Mus musculus (house mouse) ]

Gene ID: 14693, updated on 13-Apr-2024

Summary

Official Symbol
Gnb2provided by MGI
Official Full Name
guanine nucleotide binding protein (G protein), beta 2provided by MGI
Primary source
MGI:MGI:95784
See related
Ensembl:ENSMUSG00000029713 AllianceGenome:MGI:95784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gnb-2; Hg2c1
Summary
Predicted to enable several functions, including GTPase activity; GTPase binding activity; and calcium channel regulator activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Located in myelin sheath. Is expressed in several structures, including cerebral cortex; eye; liver; oocyte; and pancreas epithelium. Orthologous to human GNB2 (G protein subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 211.7), adrenal adult (RPKM 206.9) and 28 other tissues See more
Orthologs
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Genomic context

See Gnb2 in Genome Data Viewer
Location:
5 G2; 5 76.54 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137526389..137533085, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137528127..137533449, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9130604C24 gene Neighboring gene GRB10 interacting GYF protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:137974329-137974544 Neighboring gene STARR-positive B cell enhancer ABC_E1692 Neighboring gene microRNA 6418 Neighboring gene predicted gene 17112 Neighboring gene actin-like 6B Neighboring gene transferrin receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables signaling receptor complex adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of heterotrimeric G-protein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in myelin sheath HDA PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Names
g protein subunit beta-2
guanine nucleotide binding protein, beta 2
guanine nucleotide-binding protein, beta-2 subunit
heterotrimeric guanine nucleotide-binding protein 2c1
transducin beta chain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010312.5NP_034442.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

    See identical proteins and their annotated locations for NP_034442.1

    Status: VALIDATED

    Source sequence(s)
    AI892088, AK146941, BF458455
    Consensus CDS
    CCDS19769.1
    UniProtKB/Swiss-Prot
    P62880
    UniProtKB/TrEMBL
    E9QKR0, Q3U9V4
    Related
    ENSMUSP00000031726.9, ENSMUST00000031726.15
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137526389..137533085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504553.5XP_006504616.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1

    See identical proteins and their annotated locations for XP_006504616.1

    UniProtKB/Swiss-Prot
    P62880
    UniProtKB/TrEMBL
    E9QKR0, Q3U9V4
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]