Format

Send to:

Choose Destination

GNA11 G protein subunit alpha 11 [ Homo sapiens (human) ]

Gene ID: 2767, updated on 8-Nov-2020

Summary

Official Symbol
GNA11provided by HGNC
Official Full Name
G protein subunit alpha 11provided by HGNC
Primary source
HGNC:HGNC:4379
See related
Ensembl:ENSG00000088256 MIM:139313
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBH; FBH2; FHH2; HHC2; GNA-11; HYPOC2
Summary
The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]
Expression
Broad expression in small intestine (RPKM 57.6), duodenum (RPKM 46.4) and 23 other tissues See more
Orthologs

Genomic context

See GNA11 in Genome Data Viewer
Location:
19p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (3094362..3123999)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3094408..3121468)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene TLE family member 5, transcriptional modulator Neighboring gene uncharacterized LOC105372242 Neighboring gene ribosomal protein L35 pseudogene Neighboring gene G protein subunit alpha 15 Neighboring gene GNA15 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env PLC-beta activation and intracellular Ca2+ release are required for HIV-1 gp120-mediated Rac-1 activation and membrane fusion via the G-alpha(q/11) family of G proteins PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
type 2A serotonin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled acetylcholine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
action potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to pH IEA
Inferred from Electronic Annotation
more info
 
developmental pigmentation IEA
Inferred from Electronic Annotation
more info
 
entrainment of circadian clock ISS
Inferred from Sequence or Structural Similarity
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
phospholipase C-activating dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phototransduction, visible light ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet activation TAS
Traceable Author Statement
more info
 
regulation of melanocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
skeletal system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosomal membrane HDA PubMed 
photoreceptor outer segment ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein subunit alpha-11
Names
g alpha-11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
guanine nucleotide-binding protein G(y) subunit alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033852.2 RefSeqGene

    Range
    4953..34590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002067.5NP_002058.2  guanine nucleotide-binding protein subunit alpha-11

    See identical proteins and their annotated locations for NP_002058.2

    Status: REVIEWED

    Source sequence(s)
    AC005262, BC089041, HY118575, KF456478
    Consensus CDS
    CCDS12103.1
    UniProtKB/Swiss-Prot
    P29992
    Related
    ENSP00000078429.3, ENST00000078429.9
    Conserved Domains (1) summary
    cd00066
    Location:40353
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    3094362..3123999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center