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Skp2 S-phase kinase-associated protein 2 (p45) [ Mus musculus (house mouse) ]

Gene ID: 27401, updated on 13-Jun-2017
Official Symbol
Skp2provided by MGI
Official Full Name
S-phase kinase-associated protein 2 (p45)provided by MGI
Primary source
MGI:MGI:1351663
See related
Ensembl:ENSMUSG00000054115 Vega:OTTMUSG00000045656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p45; FWD1; FBXL1; 4930500A04Rik
Orthologs
Location:
15; 15 A1
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (9111982..9155425, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (9041742..9070207, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene RAN binding protein 3-like Neighboring gene predicted gene, 46511 Neighboring gene NAD kinase 2, mitochondrial Neighboring gene LMBR1 domain containing 2 Neighboring gene UDP glycosyltransferases 3 family pseudogene Neighboring gene UDP glycosyltransferases 3 family, polypeptide A1

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC102075, MGC116668, 4930500A04Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
S-phase kinase-associated protein 2
Names
F-box protein Skp2
F-box/WD-40 protein 1
cyclin A/CDK2-associated protein p45

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285980.1NP_001272909.1  S-phase kinase-associated protein 2 isoform c

    See identical proteins and their annotated locations for NP_001272909.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks part of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC161575, AK006221, AK015652, BC092236
    Consensus CDS
    CCDS79360.1
    UniProtKB/TrEMBL
    A0A087WQ11, Q569Z9
    Related
    ENSMUSP00000139997.1, OTTMUSP00000066472, ENSMUST00000190131.1, OTTMUST00000119547
    Conserved Domains (3) summary
    cd09293
    Location:158310
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:102132
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:62107
    F-box-like; F-box-like
  2. NM_013787.3NP_038815.1  S-phase kinase-associated protein 2 isoform a

    See identical proteins and their annotated locations for NP_038815.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC161575, AK166034, BY740905
    Consensus CDS
    CCDS37037.1
    UniProtKB/Swiss-Prot
    Q9Z0Z3
    UniProtKB/TrEMBL
    Q569Z9
    Related
    ENSMUSP00000094225.3, OTTMUSP00000066470, ENSMUST00000096482.9, OTTMUST00000119545
    Conserved Domains (3) summary
    cd09293
    Location:193345
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:137167
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:97142
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

    Range
    9111982..9155425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245359.1XP_011243661.1  S-phase kinase-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011243661.1

    Conserved Domains (3) summary
    cd09293
    Location:203355
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:147177
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:107152
    F-box-like; F-box-like

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145468.1: Suppressed sequence

    Description
    NM_145468.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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