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SKP2 S-phase kinase associated protein 2 [ Homo sapiens (human) ]

Gene ID: 6502, updated on 9-Feb-2020

Summary

Official Symbol
SKP2provided by HGNC
Official Full Name
S-phase kinase associated protein 2provided by HGNC
Primary source
HGNC:HGNC:10901
See related
Ensembl:ENSG00000145604 MIM:601436
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p45; FBL1; FLB1; FBXL1
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]
Expression
Broad expression in placenta (RPKM 19.8), lymph node (RPKM 3.9) and 22 other tissues See more
Orthologs

Genomic context

See SKP2 in Genome Data Viewer
Location:
5p13.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (36152043..36184319)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (36152091..36184143)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene UDP glycosyltransferase family 3 member A2 Neighboring gene LMBR1 domain containing 2 Neighboring gene RNA, U6 small nuclear 1305, pseudogene Neighboring gene microRNA 580 Neighboring gene NAD kinase 2, mitochondrial Neighboring gene RAN binding protein 3 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Cdk9, the catalytic subunit of P-TEFb, is ubiquitinated by Skp1/Cul1/F-box protein E3 ubiquitin ligase Skp2, which facilitates the formation of the RNA-protein complex between P-TEFb, Tat, and TAR, thereby enhancing Tat transactivation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1366

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intracellular estrogen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein K48-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
S-phase kinase-associated protein 2
Names
CDK2/cyclin A-associated protein p45
F-box/LRR-repeat protein 1
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
p45skp2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029643.2 RefSeqGene

    Range
    5069..37277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243120.1NP_001230049.1  S-phase kinase-associated protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001230049.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate coding exons compared to variant 1. The first causes the translation start site to move downstream while the second is in-frame. The resulting isoform (3) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC008942, AK296223, CA415778, DA223617
    Consensus CDS
    CCDS58944.1
    UniProtKB/Swiss-Prot
    Q13309
    Related
    ENSP00000478031.1, ENST00000620197.4
    Conserved Domains (2) summary
    sd00034
    Location:1843
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:17131
    AMN1; Antagonist of mitotic exit network protein 1
  2. NM_005983.4NP_005974.2  S-phase kinase-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_005974.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB050979, AC008942, AK296223, CA415778, DA223617
    Consensus CDS
    CCDS3916.1
    UniProtKB/Swiss-Prot
    Q13309
    UniProtKB/TrEMBL
    A0A024R069
    Related
    ENSP00000274255.6, ENST00000274255.11
    Conserved Domains (3) summary
    sd00034
    Location:183207
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:97141
    F-box-like; F-box-like
    cl28166
    Location:193345
    AMN1; Antagonist of mitotic exit network protein 1
  3. NM_032637.4NP_116026.1  S-phase kinase-associated protein 2 isoform 2

    See identical proteins and their annotated locations for NP_116026.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC007441, DA223617
    Consensus CDS
    CCDS3915.1
    UniProtKB/Swiss-Prot
    Q13309
    Related
    ENSP00000274254.5, ENST00000274254.9
    Conserved Domains (3) summary
    sd00034
    Location:183207
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:97141
    F-box-like; F-box-like
    cl28166
    Location:193345
    AMN1; Antagonist of mitotic exit network protein 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    36152043..36184319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514082.3XP_011512384.1  S-phase kinase-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011512384.1

    Conserved Domains (3) summary
    cd09293
    Location:193345
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:183207
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:97143
    F-box-like; F-box-like
  2. XM_011514083.3XP_011512385.1  S-phase kinase-associated protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011512385.1

    Conserved Domains (2) summary
    cd09293
    Location:24176
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:1438
    LRR_AMN1; leucine-rich repeat [structural motif]
  3. XM_017009753.1XP_016865242.1  S-phase kinase-associated protein 2 isoform X3

RNA

  1. XR_001742203.2 RNA Sequence

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