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Prmt5 protein arginine N-methyltransferase 5 [ Mus musculus (house mouse) ]

Gene ID: 27374, updated on 8-Jul-2024

Summary

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Official Symbol
Prmt5provided by MGI
Official Full Name
protein arginine N-methyltransferase 5provided by MGI
Primary source
MGI:MGI:1351645
See related
Ensembl:ENSMUSG00000023110 AllianceGenome:MGI:1351645
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jbp1; Skb1
Summary
This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation and the assembly of small nuclear ribonucleoproteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 31.6), CNS E14 (RPKM 26.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Prmt5 in Genome Data Viewer
Location:
14 C2; 14 27.82 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54744639..54754927, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54507182..54517470, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene rad and gem related GTP binding protein 2 Neighboring gene STARR-positive B cell enhancer mm9_chr14:55113133-55113433 Neighboring gene predicted gene, 41153 Neighboring gene nuclear encoded tRNA arginine 6 (anticodon ACG) Neighboring gene predicted gene, 53858

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PRMT5 promotes retinoblastoma development. Jiang Y, et al. Hum Cell, 2023 Jan. PMID 36331723
  2. PRMT5 acts as a tumor suppressor by inhibiting Wnt/β-catenin signaling in murine gastric tumorigenesis. Tang Y, et al. Int J Biol Sci, 2022. PMID 35864961, Free PMC Article
  3. Endothelial PRMT5 plays a crucial role in angiogenesis after acute ischemic injury. Ye Q, et al. JCI Insight, 2022 May 9. PMID 35531958, Free PMC Article
  4. PRMT5 in T Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation. Lewis BW, et al. J Immunol, 2022 Apr 1. PMID 35288471, Free PMC Article
  5. Inhibition of PRMT5 attenuates cerebral ischemia/reperfusion-Induced inflammation and pyroptosis through suppression of NF-κB/NLRP3 axis. Wu X, et al. Neurosci Lett, 2022 Apr 17. PMID 35278646

See all (127) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Excessive fatty acids activate PRMT5/MDM2/Drosha pathway to regulate miRNA biogenesis and lipid metabolism.
    Title: Excessive fatty acids activate PRMT5/MDM2/Drosha pathway to regulate miRNA biogenesis and lipid metabolism.
  2. PRMT5 Promotes T follicular helper Cell Differentiation and Germinal Center Responses during Influenza Virus Infection.
    Title: PRMT5 Promotes T follicular helper Cell Differentiation and Germinal Center Responses during Influenza Virus Infection.
  3. Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice.
    Title: Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice.
  4. PRMT5-mediated homologous recombination repair is essential to maintain genomic integrity of neural progenitor cells.
    Title: PRMT5-mediated homologous recombination repair is essential to maintain genomic integrity of neural progenitor cells.
  5. Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia.
    Title: Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia.
  6. PRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment.
    Title: PRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment.
  7. PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors.
    Title: PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors.
  8. Prmt5 deficient mouse B cells display RNA processing complexity and slower colorectal tumor progression.
    Title: Prmt5 deficient mouse B cells display RNA processing complexity and slower colorectal tumor progression.
  9. The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine.
    Title: The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine.
  10. Protein arginine methyltransferase 5-mediated arginine methylation stabilizes Kruppel-like factor 4 to accelerate neointimal formation.
    Title: Protein arginine methyltransferase 5-mediated arginine methylation stabilizes Kruppel-like factor 4 to accelerate neointimal formation.
Submit: New GeneRIF Correction See all GeneRIFs (78)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (7)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables E-box binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H2AR3 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H4R3 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H4R3 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H4R3 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone arginine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein-arginine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-arginine omega-N symmetric methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription termination ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi ribbon formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endothelial cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression via chromosomal CpG island methylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within peptidyl-arginine N-methylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in peptidyl-arginine methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal snRNP assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in spliceosomal snRNP assembly NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of histone methyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of methylosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein arginine N-methyltransferase 5
Names
Jak-binding protein 1
SKB1 homolog
histone-arginine N-methyltransferase PRMT5
shk1 kinase-binding protein 1 homolog
NP_001300835.1
NP_001300836.1
NP_038796.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313906.1 → NP_001300835.1  protein arginine N-methyltransferase 5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK076346, AK084106, AK165165, CF726158
    UniProtKB/Swiss-Prot
    Q3TNN1, Q8CIG8, Q9QZS9
    Conserved Domains (2) summary
    pfam05185
    Location:164 → 600
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam16950
    Location:165 → 446
    SAMBD; SAM-binding_domain

  2. NM_001313907.1 → NP_001300836.1  protein arginine N-methyltransferase 5 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK076346, AK084106, AK165165, BY101080
    UniProtKB/Swiss-Prot
    Q3TNN1, Q8CIG8, Q9QZS9
    Conserved Domains (2) summary
    pfam05185
    Location:77 → 513
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam16950
    Location:78 → 359
    SAMBD; SAM-binding_domain

  3. NM_013768.3 → NP_038796.2  protein arginine N-methyltransferase 5 isoform 1

    See identical proteins and their annotated locations for NP_038796.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK076346, AK165165, BY064945
    Consensus CDS
    CCDS27091.1
    UniProtKB/Swiss-Prot
    Q3TNN1, Q8CIG8, Q9QZS9
    UniProtKB/TrEMBL
    A0A0R4J049
    Related
    ENSMUSP00000023873.6, ENSMUST00000023873.12
    Conserved Domains (2) summary
    pfam05185
    Location:183 → 619
    PRMT5; PRMT5 arginine-N-methyltransferase
    pfam16950
    Location:184 → 465
    SAMBD; SAM-binding_domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    54744639..54754927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CIG8.3 GenPept UniProtKB/Swiss-Prot:Q8CIG8

Gene LinkOut

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