Conserved Protein Domain Family
PRMT5

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pfam05185: PRMT5 
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PRMT5 arginine-N-methyltransferase
The human homologue of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase. These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes.
Statistics
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PSSM-Id: 282971
View PSSM: pfam05185
Aligned: 30 rows
Threshold Bit Score: 529.131
Threshold Setting Gi: 75002871
Created: 24-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam05185 is classified as a model that may span more than one domain.
pfam05185 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4GQB_A       181 GEEKTWMWWHNFRTLC-DYSk-rIAVALEIG--ADL-PSN----HVIDRWLGEPIKAAILPTSIFLTNKK-GFPVLSKMH 250
gi 124473364 151 EITKDWIKYNQIRQEL-QFN---IPILLRLK--KEM-TTK----NEQRKWLSENIRFVHLNQDLFSMNDQ-GAPKLDDIQ 218
gi 67460430  162 ESNDPWNWWNNLRMVT-KHSt-kVKVVIELN--DADrPSK----ETVRRWLGEPIEAIIIPSSLFVRNRS-NYCVLKKEW 232
gi 122068191 167 GADDTWNWWNNFRSYA-DFDt-hVKVALEFT--ADI-PEK----REIYRWLGEPVDAVVLSSNIFLTNAN-NYAVLSKAH 236
gi 74800839  104 TVESPWCWWNTFRCHA-DYNp-tVKVALELT--ADV-PKQ----EEIFRWLGEPVDAIVLPANIFLTNAK-NYPVLSKAH 173
3UA3_A       215 EHVDLWTIWADFRKNCgNFSgvyFQVALTIS--SEL-PDEltelKLVDRWKAEPLAAFVIESGLFISGRN-GEASIPSAH 290
gi 75002871  191 EQLSEWQITNTIINASp-----nTKIGLSLKidSNLsRISi---EDYSRFFGEPIKCMFINYDFFESKRS------GSSI 256
gi 74953024  200 DSLNT---WNMIYELC-GFSd-kLKVCLKLQ------PVE----TDLELWLSEPVKCVVLSEETILTDKR---VVLNKAV 261
gi 74842609  185 DIINGWNLWAKFISYC-NFNyshLGLALELSniNNIdLSN----IQLDVWKSEPVKLIIIPLDAFLLDTKtGYPYLPKKL 259
gi 74878077  192 HIINGWNIWAKFISYC-NFDfsnMNVAIEFVniKDInINN----INLDIWKSEPVKLIIIPLDVFFIDSKtGYPYLPKKL 266
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4GQB_A       251 QRLIFRLL-KLEVQFIIT------------------------------------------------G-TNHHSEKEfcsY 280
gi 124473364 219 NQFLTSYFqFENYISISA------------------------------------------------K-SPQIDLAD---H 246
gi 67460430  233 QLIVGHFIsVRANIIIST------------------------------------------------N-PNDKALCQ---Y 260
gi 122068191 237 QELLVLFYrTFGCHFIVKa-----------------------------------------------N-PDDKRLVH---Y 265
gi 74800839  174 QSMLNLFYrTFSCHFILKa-----------------------------------------------N-PSDGHLGH---Y 202
3UA3_A       291 INLLKHLWtTDALRIVLRat---------------------------------------------tD-TFKYNTSIkseY 324
gi 75002871  257 SEVLKHSMrAKVPISIYFnd---------------------------------------------nI-SSNVKSIIknsY 290
gi 74953024  262 SSQLSILM-KNNVKILLDsnlnykslisssvsv------------------qnsdsdnfveevvmrDlESEIDVKD---V 319
gi 74842609  260 KDFLIYFFrKNIEVLLITnedinkmnnhfihlkneycneyqhnicnnemdsydindnnnnnnnnynIsNSIHTKTNnnyY 339
gi 74878077  267 KDLLIFFFrKNIDVVLTArkkggdnyiyntesggiylegkki-eidemnmiektnnryklgkdakeNpEAKNEFVDniyY 345
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4GQB_A       281 LQ----YLEYLSQNRP------PPNAYELFA-KGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRV 349
gi 124473364 247 RQ----YLIHLFKNQQ------PLSEQAHLA-SEFFDELQIPLQPYKDNLNSGTYEVFEQDKIKYDLYEDACRKYLKNVK 315
gi 67460430  261 AD----YVNKLIND----------NCDKHML-NSYENMLEIPLQPLCDNLDTYTYEVFETDPVKYKLYQDAVQAALLDRV 325
gi 122068191 266 AD----YIKYILRS----------NYKKDPM-QGYDDLLEIPLQPLYDNLDSFTYEVFEKDPVKYILYQNAIEEALRDRV 330
gi 74800839  203 VD----YIKYTIQH----------NYVKNPL-HGYEDLLQIPLQPLYDNLDSFTYEVFEKDPVKYIYYQNAIEQALLDRV 267
3UA3_A       325 SQalrhAVRNVNYRSRpdvgegSNDSTHYLNvIEYKDVLQAPLQPLSENLDSGVYNTFEQDQIKYDVYGEAVVGALKDLG 404
gi 75002871  291 NN----IVKFIKS-FP------PLSSKQKYE-YNYIDVLQMPLQPLSNNLKSIEYEVFERDHIKYEKYFHAVKLFLSENN 358
gi 74953024  320 LK----AVKRCYSRIG------PLTIRELYG-RGYEDLFQVPLQPLRDNLDSSTYNEFEKCSFKYNCYDQAIHSFISTKL 388
gi 74842609  340 LKcciyYIKRLFMSIE------NFDNDSLFD-SFYWDYLQIPLQPLKDNLSSQTYEVFEKDRKKYEQYELATSKYLSNWK 412
gi 74878077  346 LKcciyYLKRLFMSIE------NFDTHTLFD-SSYWDYLQIPLQPLKDNLSSQVYEIFERDKTKYEKYELAISKYLCDEL 418
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4GQB_A       350 PEEekd-----------------------tnvQVLMVLGAGRGPLVNASLRAAKQAD--R--------RIKLYAVEKNPN 396
gi 124473364 316 KAE-----------------------------INILMAGAGRGGILERVIFAAQGAK--C--------KTKIVALEKNPY 356
gi 67460430  326 SAAeak-----------------------tklTVVMLLGGGRGPLARAVFNAAELTK--R--------KVRLYIIEKNPN 372
gi 122068191 331 PSSeiq-----------------------trtSIIMVVGGGRGPLVRAALNAASKSK--R--------MVKIYVVEKNPN 377
gi 74800839  268 PEAdra-----------------------tatTIIMVVGGGRGPLVRAALNASQTTN--C--------KVKVYVIEKNPN 314
3UA3_A       405 ADGrk--------------------------tvVIYLLGGGRGPIGTKILKSEREYNn-TfrqgqeslKVKLYIVEKNPN 457
gi 75002871  359 IKSee---------------------------ikVLIVGSGRGGLIKSAFNAFSYIGi-N--------SFKIMCVEKNRN 402
gi 74953024  389 ISLnqlsklnsn------------isysspvnYIVYVLGAGRGPLVEVVMEVFKRNNipTn-------DFVVFALEKNPY 449
gi 74842609  413 KGKkinnknkqsnknknnnnnnnmeeqqndhkITIFVVGAGRGPLVDTTLSALQKNEm-T--------DYEIYAIEKNDS 483
gi 74878077  419 NKKkynndnlnlsneennnsdkskisksderhFIIFVVGAGRGPLVDCTLKALETNKi-N--------NYSIYAIEKNDS 489
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4GQB_A       397 AVVTLE-NW-QFEE---WgsQ-VTVVSSDMREWVAPE----------KADIIVSELLGSFADNELSPECLDGAQH----- 455
gi 124473364 357 AYMTLVfQKkRQKQ---W--KdVEIVLDDLKSWQTEL----------KFDLIVSELLGSFGDNELSPECLMWAQR----- 416
gi 67460430  373 AIRTLS-NMvK-TL---WadKdVHIFSKDMRDFSPPE----------LADIMVSELLGSFGDNELSPECLDGALK----- 432
gi 122068191 378 AIVTLS-ALiN-EL---WkdKnIELISTDMREFEPPE----------KADILVSELLGSFGDNELSPECLDGAQK----- 437
gi 74800839  315 AIVTLT-AHiN-EL---WrdRnVELISTDMREFNPPE----------KADILVSELLGSFGDNELSPECLDGAQK----- 374
3UA3_A       458 AIVTL--KYxNVRT---WkrR-VTIIESDXRSLPGIAkdr----gfeQPDIIVSELLGSFGDNELSPECLDGVTG----- 522
gi 75002871  403 AVLTLK-AKmNYKDnanWe-K-VDIINSDIRTVQLDE----------KYDLIISELIGSFGDNELSPECLIFAQR----- 464
gi 74953024  450 TMLTLD-HKiQNNR---Wt-N-VRLIYSDMRDLNRGMvqsnlnnaskTVHLVLSELLGSFGDNELSPECLYGFERsfnsl 523
gi 74842609  484 AIIILN-NRvQTEE---W--KnVKVIHSDIRYLDIPK----------KADIIISELLGSFGDNELFPECMDGIKK----- 542
gi 74878077  490 AILVLK-NRlLNEK---W--KnVKVINSDMRHLKIDI----------KADLIVSELLGSFGDNELFPECLDSMEK----- 548
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4GQB_A       456 FLKDD-GVSIPGEYTSFLAPISSSKLYNEVRAcrek---------------------------drdpEAQFEMPYVVRLH 507
gi 124473364 417 FLQPD-AVSIPCDSVSYCVPVSCPQLHAKVKK-----------------------------------SYGYDSSYVVHYQ 460
gi 67460430  433 LLKPD-GISIPYKSTSYINPLMSAVLHQNVCQll-------------------------------ptYPAFDYGYVSLLK 480
gi 122068191 438 HLKPD-GVSIPCKSTSYLNPCMAPKIYSQIRSmekslha----------------------kdrivtSRYMEGTYVAYLK 494
gi 74800839  375 HLKDS-GISIPCKSTSYINPCFGSKVYNQVRLlersphw----------------------kdrvisSRHMEQAYVAYQK 431
3UA3_A       523 FLKPT-TISIPQKYTSYVKPIXSTHIHQTIKAqsipylsraipshgrgepeldedexwiqkypqghvRNNXDQIYVVYLS 601
gi 75002871  465 FLKPS-GIMIPQRYTSYLEPISCRKVWNNAVSyl--------------------------------kSKTLEIPFVSRLK 511
gi 74953024  524 FSQGVrLEFIPGSYTSYVMPLHCPQIWAKIKSfe--------------------------------nTKNFHMPYTVYLK 571
gi 74842609  543 FLKDD-GISIPMNCVSYLEPISCSALYHKVMEnn--------------------------------iSGGNESFYVVNMY 589
gi 74878077  549 YLKED-GISIPQNCLSYVEPISCAKVYYKLCNnn--------------------------------fPGNNENFYVINLY 595
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4GQB_A       508 NFHQLSAP--QPCFTFSHPNRD-P----M--IDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFS 578
gi 124473364 461 KYYTIHDI--QKCMQFKHPDFN-N----E--NQLAQEQNLVFECKQDLLIHGMAGYFTSKLYEDIELSTHPNNSTPDMYS 531
gi 67460430  481 NIYHIDEP--QALFEFVHPNRA-E----N--IDNTRCKTVSFKVNKDCVLHGIGGYFDTHLYKDICLSINPLTHTPGMFS 551
gi 122068191 495 NAYHIDNP--QAVFEFVHPNLD-P----I--IDNSRYKTLRFKAQLDCVMHGFCGYFDSVLYKDITISIHPFTHTKGLAS 565
gi 74800839  432 NAYHIDNP--QPLFEFVHPNRE-Sd---Dp-IDNNRYKTVRFRAALDCVMNGFTGYFDTVLYKDITLSIHPFTHTKGLAS 504
3UA3_A       602 KYIPLAETt-KPVFTFEHPNF--X----N--SSNERSDSIEFVXDRNADLXGFAGYFDLQLYKTVXLSIEPSTHTPGXVS 672
gi 75002871  512 SHYKISLEgpKEVFSFHHPTE--In---EeiMENEIFTTVEFTSRAESTLHGFLGYFKCDLYNEVGFSTLPSdLTNNPIS 586
gi 74953024  572 TYYNVGTMy-MDCFSFEHPKTQdSktsqI--SILERYKVIKFVARSDCYVHGFGAYFKCTLFDKIEISTLPQ-DSENLKS 647
gi 74842609  590 SYTKISQEssKECFFFQVPPIHtKq--dN--SHNYRYKNINFKIKMDTYIHGFLCYFKSQLYDDVYISIEPKTHTPNLHS 665
gi 74878077  596 SYYKISEGp-KECFYFDIPSKNiKn--dN--SNNNRYKNINFKVINDSYLHGFLCYFNSKLYNDVYLSIEPNTHTNNLHS 670
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|.
4GQB_A       579 WFPILFPIKQPitvreGQTICVRFWRCSNSKKVWYEWAVTA 619
gi 124473364 532 WFPIYFPFEKPvniakKQKLKFTIKRVNNEEGVWYEWFNSV 572
gi 67460430  552 WFPMFFA-TRPrtlreGQTISIQFWRCVDATKVWYEWQVVN 591
gi 122068191 566 WFSMFFPLTEPvqvraGEEIVVNFWRCVASHKVWYEWNITA 606
gi 74800839  505 WFSMFIPLTDPvqlrkGDEITVHFWRCVASHKVWYEWSLSA 545
3UA3_A       673 WFPAVIPLRDQlrvgeGDRISLKIDRKVDNTGVWYEWHVEK 713
gi 75002871  587 WFEFFIPISNPillkkFDKLTFNIWRKSNKDRVWYEWLVTK 627
gi 74953024  648 WFPMFFPLEIPfpvkkSQVITLHIWRKVNDLKVWYEWAFTT 688
gi 74842609  666 WFPLYIPINKIqflkkGQNLSFSIWRLTDHQKIWYEWCINE 706
gi 74878077  671 WYPLFIPINKIiflknKQNLSFSIWRLTDNHKIWYEWCVNE 711
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