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MOCS3 molybdenum cofactor synthesis 3 [ Homo sapiens (human) ]

Gene ID: 27304, updated on 5-Apr-2020

Summary

Official Symbol
MOCS3provided by HGNC
Official Full Name
molybdenum cofactor synthesis 3provided by HGNC
Primary source
HGNC:HGNC:15765
See related
Ensembl:ENSG00000124217 MIM:609277
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBA4
Summary
Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. The protein encoded by this gene adenylates and activates molybdopterin synthase, an enzyme required for biosynthesis of MoCo. This gene contains no introns. A pseudogene of this gene is present on chromosome 14. [provided by RefSeq, Nov 2012]
Orthologs

Genomic context

See MOCS3 in Genome Data Viewer
Location:
20q13.13
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (50958818..50963929)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (49575351..49578400)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene activity dependent neuroprotector homeobox Neighboring gene proteasome 26S subunit, non-ATPase, 10 pseudogene 1 Neighboring gene ADNP antisense RNA 1 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 1, catalytic Neighboring gene Sharpr-MPRA regulatory region 8647 Neighboring gene potassium voltage-gated channel modifier subfamily G member 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9252, dJ914P20.3

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
URM1 activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
URM1 activating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molybdopterin-synthase adenylyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
molybdopterin-synthase sulfurtransferase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotidyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotidyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sulfurtransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
thiosulfate sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiosulfate sulfurtransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
Mo-molybdopterin cofactor biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
enzyme active site formation via cysteine modification to L-cysteine persulfide IDA
Inferred from Direct Assay
more info
PubMed 
molybdopterin cofactor biosynthetic process TAS
Traceable Author Statement
more info
 
protein modification by small protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein urmylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA thio-modification IDA
Inferred from Direct Assay
more info
PubMed 
tRNA wobble position uridine thiolation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA wobble uridine modification IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
adenylyltransferase and sulfurtransferase MOCS3
Names
MPT synthase sulfurylase
UBA4, ubiquitin-activating enzyme E1 homolog
molybdenum cofactor synthesis protein 3
molybdopterin synthase sulfurylase
ubiquitin-like modifier activating enzyme 4
NP_055299.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014484.5NP_055299.1  adenylyltransferase and sulfurtransferase MOCS3

    See identical proteins and their annotated locations for NP_055299.1

    Status: REVIEWED

    Source sequence(s)
    AF102544, AI942426, AL034553, BC015939, BQ188547, BY995583, DB452633, HY215239
    Consensus CDS
    CCDS13435.1
    UniProtKB/Swiss-Prot
    O95396
    Related
    ENSP00000244051.1, ENST00000244051.3
    Conserved Domains (2) summary
    cd00757
    Location:62285
    ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...
    cd01526
    Location:327460
    RHOD_ThiF; Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    50958818..50963929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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