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Mocs3 molybdenum cofactor synthesis 3 [ Mus musculus (house mouse) ]

Gene ID: 69372, updated on 13-Oct-2022

Summary

Official Symbol
Mocs3provided by MGI
Official Full Name
molybdenum cofactor synthesis 3provided by MGI
Primary source
MGI:MGI:1916622
See related
Ensembl:ENSMUSG00000074576 AllianceGenome:MGI:1916622
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Uba4; 1700020H17Rik
Summary
Predicted to enable URM1 activating enzyme activity; nucleotidyltransferase activity; and thiosulfate sulfurtransferase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process; protein urmylation; and tRNA wobble position uridine thiolation. Predicted to act upstream of or within tRNA processing. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in central nervous system; retina inner nuclear layer; retina layer; and retina outer nuclear layer. Orthologous to human MOCS3 (molybdenum cofactor synthesis 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Mocs3 in Genome Data Viewer
Location:
2; 2 H3
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (168072542..168074223)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (168230622..168232303)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 20716 Neighboring gene activity-dependent neuroprotective protein Neighboring gene dolichol-phosphate (beta-D) mannosyltransferase 1 Neighboring gene 28S ribosomal protein S18c, mitochondrial pseudogene Neighboring gene potassium voltage-gated channel, subfamily G, member 1

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables URM1 activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables URM1 activating enzyme activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molybdopterin-synthase adenylyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables molybdopterin-synthase sulfurtransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotidyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables sulfurtransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables thiosulfate sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thiosulfate sulfurtransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-like modifier activating enzyme activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in molybdopterin cofactor metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein urmylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA thio-modification ISO
Inferred from Sequence Orthology
more info
 
involved_in tRNA wobble position uridine thiolation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tRNA wobble uridine modification ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adenylyltransferase and sulfurtransferase MOCS3
Names
MPT synthase sulfurylase
NP_001153802.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160330.1NP_001153802.1  adenylyltransferase and sulfurtransferase MOCS3

    See identical proteins and their annotated locations for NP_001153802.1

    Status: VALIDATED

    Source sequence(s)
    BE133066, BE333092, BG083535, BX005039, BY727851
    Consensus CDS
    CCDS50802.1
    UniProtKB/Swiss-Prot
    A2BDX3
    Related
    ENSMUSP00000096670.4, ENSMUST00000099071.5
    Conserved Domains (3) summary
    PRK07411
    Location:56460
    PRK07411; hypothetical protein; Validated
    cd00757
    Location:62285
    ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...
    cd01526
    Location:327460
    RHOD_ThiF; Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    168072542..168074223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)