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Dok3 docking protein 3 [ Mus musculus (house mouse) ]

Gene ID: 27261, updated on 2-Nov-2024

Summary

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Official Symbol
Dok3provided by MGI
Official Full Name
docking protein 3provided by MGI
Primary source
MGI:MGI:1351490
See related
Ensembl:ENSMUSG00000035711 AllianceGenome:MGI:1351490
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dokl
Summary
Acts upstream of or within Ras protein signal transduction. Located in cytoplasm. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human DOK3 (docking protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 71.0), mammary gland adult (RPKM 16.8) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Dok3 in Genome Data Viewer
Location:
13 B1; 13 30.06 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55671044..55678158, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55523231..55530345, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene drebrin 1 Neighboring gene microRNA 6944 Neighboring gene PDZ and LIM domain 7 Neighboring gene microRNA 6945 Neighboring gene STARR-positive B cell enhancer ABC_E10796 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:55637802-55638169 Neighboring gene DEAD box helicase 41 Neighboring gene predicted gene, 46416 Neighboring gene family with sequence similarity 193, member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of Dok-3 in Non-tumor Cells Induces Malignant Transformation of Benign Epithelial Tumor Cells of the Intestine. Arimura S, et al. Cancer Res Commun, 2022 Dec. PMID 36970719, Free PMC Article
  2. Dok3 is involved in cisplatin-induced acute kidney injury via regulation of inflammation and apoptosis. Yang YY, et al. Biochem Biophys Res Commun, 2021 Sep 10. PMID 34245977
  3. DOK3 is involved in microglial cell activation in neuropathic pain by interacting with GPR84. Gao WS, et al. Aging (Albany NY), 2020 Dec 3. PMID 33281117, Free PMC Article
  4. DOK3 Modulates Bone Remodeling by Negatively Regulating Osteoclastogenesis and Positively Regulating Osteoblastogenesis. Cai X, et al. J Bone Miner Res, 2017 Nov. PMID 28650106, Free PMC Article
  5. DOK3 Degradation is Required for the Development of LPS-induced ARDS in Mice. Liu N, et al. Curr Gene Ther, 2016. PMID 28590889

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11.
    Title: DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11.
  2. Loss of Dok-3 in Non-tumor Cells Induces Malignant Transformation of Benign Epithelial Tumor Cells of the Intestine.
    Title: Loss of Dok-3 in Non-tumor Cells Induces Malignant Transformation of Benign Epithelial Tumor Cells of the Intestine.
  3. DOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3 signaling and S100a8/9 production in neutrophils.
    Title: DOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3 signaling and S100a8/9 production in neutrophils.
  4. Dok3 is involved in cisplatin-induced acute kidney injury via regulation of inflammation and apoptosis.
    Title: Dok3 is involved in cisplatin-induced acute kidney injury via regulation of inflammation and apoptosis.
  5. DOK3 is involved in microglial cell activation in neuropathic pain by interacting with GPR84.
    Title: DOK3 is involved in microglial cell activation in neuropathic pain by interacting with GPR84.
  6. Vitamin B6 inhibits macrophage activation to prevent lipopolysaccharide-induced acute pneumonia in mice.
    Title: Vitamin B6 inhibits macrophage activation to prevent lipopolysaccharide-induced acute pneumonia in mice.
  7. Dok3 suppresses Card9 signaling, and disrupting Dok3-Card9 interaction or inhibiting PP1 activity represents therapeutic opportunities to develop drugs to combat candidaemia.
    Title: Dok3-protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity.
  8. Dok-3(-/-) mice display different immune clustering and Tim-3 expression.
    Title: Dok-3 deficient mice display different immune clustering and Tim-3 expression.
  9. DOK3 regulates bone remodeling by negatively regulating M-CSF- and RANKL-mediated osteoclastogenesis and positively regulating osteoblastogenesis.
    Title: DOK3 Modulates Bone Remodeling by Negatively Regulating Osteoclastogenesis and Positively Regulating Osteoblastogenesis.
  10. findings demonstrate that Dok-3 and Dok-1/-2 play distinctive but cooperative roles in osteoclastogenesis and protect mice from osteopenia, providing physiological and pathophysiological insight into bone homeostasis.
    Title: Dok-3 and Dok-1/-2 adaptors play distinctive roles in cell fusion and proliferation during osteoclastogenesis and cooperatively protect mice from osteopenia.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC151299

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Ras protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
docking protein 3
Names
DOK-L
Dok-like protein
downstream of tyrosine kinase 3
p62(dok)-like protein
p62Dok-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013739.2 → NP_038767.1  docking protein 3

    See identical proteins and their annotated locations for NP_038767.1

    Status: PROVISIONAL

    Source sequence(s)
    CT009762
    Consensus CDS
    CCDS26548.1
    UniProtKB/Swiss-Prot
    Q9QZK7
    UniProtKB/TrEMBL
    Q14AA1, Q3T9H7
    Related
    ENSMUSP00000046695.5, ENSMUST00000047877.5
    Conserved Domains (2) summary
    cd01203
    Location:157 → 255
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9 → 123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    55671044..55678158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315524.1 → XP_017171013.1  docking protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9QZK7
    UniProtKB/TrEMBL
    Q14AA1, Q3T9H7
    Conserved Domains (2) summary
    cd01203
    Location:157 → 255
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9 → 123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZK7.1 GenPept UniProtKB/Swiss-Prot:Q9QZK7

Gene LinkOut

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