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Dok3 docking protein 3 [ Mus musculus (house mouse) ]

Gene ID: 27261, updated on 18-Apr-2024

Summary

Official Symbol
Dok3provided by MGI
Official Full Name
docking protein 3provided by MGI
Primary source
MGI:MGI:1351490
See related
Ensembl:ENSMUSG00000035711 AllianceGenome:MGI:1351490
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dokl
Summary
Acts upstream of or within Ras protein signal transduction. Located in cytoplasm. Orthologous to human DOK3 (docking protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 71.0), mammary gland adult (RPKM 16.8) and 9 other tissues See more
Orthologs
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Genomic context

Location:
13 B1; 13 30.06 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55671044..55678158, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55523231..55530345, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene drebrin 1 Neighboring gene microRNA 6944 Neighboring gene PDZ and LIM domain 7 Neighboring gene microRNA 6945 Neighboring gene STARR-positive B cell enhancer ABC_E10796 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:55637802-55638169 Neighboring gene DEAD box helicase 41 Neighboring gene predicted gene, 46416 Neighboring gene family with sequence similarity 193, member B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC151299

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within Ras protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
docking protein 3
Names
DOK-L
Dok-like protein
downstream of tyrosine kinase 3
p62(dok)-like protein
p62Dok-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013739.2NP_038767.1  docking protein 3

    See identical proteins and their annotated locations for NP_038767.1

    Status: PROVISIONAL

    Source sequence(s)
    CT009762
    Consensus CDS
    CCDS26548.1
    UniProtKB/Swiss-Prot
    Q9QZK7
    UniProtKB/TrEMBL
    Q14AA1, Q3T9H7
    Related
    ENSMUSP00000046695.5, ENSMUST00000047877.5
    Conserved Domains (2) summary
    cd01203
    Location:157255
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    55671044..55678158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315524.1XP_017171013.1  docking protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9QZK7
    UniProtKB/TrEMBL
    Q14AA1, Q3T9H7
    Conserved Domains (2) summary
    cd01203
    Location:157255
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3