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DOK3 docking protein 3 [ Homo sapiens (human) ]

Gene ID: 79930, updated on 11-Sep-2019

Summary

Official Symbol
DOK3provided by HGNC
Official Full Name
docking protein 3provided by HGNC
Primary source
HGNC:HGNC:24583
See related
Ensembl:ENSG00000146094 MIM:611435
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOKL
Expression
Biased expression in bone marrow (RPKM 31.4), spleen (RPKM 15.5) and 11 other tissues See more
Orthologs

Genomic context

See DOK3 in Genome Data Viewer
Location:
5q35.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (177501904..177510508, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176928905..176937490, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene proline rich 7, synaptic Neighboring gene drebrin 1 Neighboring gene PDZ and LIM domain 7 Neighboring gene uncharacterized LOC107986488 Neighboring gene DEAD-box helicase 41 Neighboring gene family with sequence similarity 193 member B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Pathways from BioSystems

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22570, FLJ39939

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
docking protein 3
Names
Dok-like protein
downstream of tyrosine kinase 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144875.2NP_001138347.1  docking protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001138347.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 5' exon structure and an alternate 3' terminal exon, and it thus initiates translation at a downstream in-frame start codon, and differs in both UTRs and the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC145098, BC004564, DA931137
    Consensus CDS
    CCDS47350.1
    UniProtKB/Swiss-Prot
    Q7L591
    Related
    ENSP00000325174.6, ENST00000312943.10
    Conserved Domains (2) summary
    cd14676
    Location:9123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
    cl17171
    Location:157215
    PH-like; Pleckstrin homology-like domain
  2. NM_001144876.2NP_001138348.1  docking protein 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains both alternate 5' and 3' terminal exons and lacks an internal in-frame exon, and it thus initiates translation at a downstream in-frame start codon, and differs in both UTRs and the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus, lacks an internal segment, and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC145098, AK097258, BC004564, DA931137
    Consensus CDS
    CCDS47349.1
    UniProtKB/Swiss-Prot
    Q7L591
    Related
    ENSP00000366316.4, ENST00000377112.8
    Conserved Domains (1) summary
    cl17171
    Location:55113
    PH-like; Pleckstrin homology-like domain
  3. NM_001308235.1NP_001295164.1  docking protein 3 isoform 4

    See identical proteins and their annotated locations for NP_001295164.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) is shorter at the N-terminus, compared to isoform 1. Both variants 4 and 5 encode isoform 4.
    Source sequence(s)
    AK026223, AL583057, BG756981, CF138017, DA931137
    Consensus CDS
    CCDS78098.1
    UniProtKB/Swiss-Prot
    Q7L591
    UniProtKB/TrEMBL
    D6RAM3
    Related
    ENSP00000421688.1, ENST00000501403.6
    Conserved Domains (2) summary
    cd01203
    Location:157255
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
  4. NM_001308236.1NP_001295165.1  docking protein 3 isoform 4

    See identical proteins and their annotated locations for NP_001295165.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) is shorter at the N-terminus, compared to isoform 1. Both variants 4 and 5 encode isoform 4.
    Source sequence(s)
    AK026223, BG756981, BI489608, CF138017, DA674730
    Consensus CDS
    CCDS78098.1
    UniProtKB/Swiss-Prot
    Q7L591
    UniProtKB/TrEMBL
    D6RAM3
    Related
    ENSP00000424726.2, ENST00000510898.6
    Conserved Domains (2) summary
    cd01203
    Location:157255
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
  5. NM_024872.2NP_079148.2  docking protein 3 isoform 1

    See identical proteins and their annotated locations for NP_079148.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC145098, AK026223, DA674730
    Consensus CDS
    CCDS4426.1
    UniProtKB/Swiss-Prot
    Q7L591
    UniProtKB/TrEMBL
    A0A024R7M5
    Related
    ENSP00000349727.4, ENST00000357198.8
    Conserved Domains (2) summary
    cd01203
    Location:213311
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:65179
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    177501904..177510508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534655.3XP_011532957.1  docking protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011532957.1

    UniProtKB/TrEMBL
    D6RAM3
    Conserved Domains (2) summary
    cd01203
    Location:157255
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
  2. XM_011534657.2XP_011532959.1  docking protein 3 isoform X3

    Conserved Domains (1) summary
    cd01203
    Location:55153
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
  3. XM_005265987.2XP_005266044.1  docking protein 3 isoform X4

    See identical proteins and their annotated locations for XP_005266044.1

    UniProtKB/Swiss-Prot
    Q7L591
    Conserved Domains (2) summary
    cd14676
    Location:9123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
    cl17171
    Location:157215
    PH-like; Pleckstrin homology-like domain
  4. XM_005265985.4XP_005266042.1  docking protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005266042.1

    UniProtKB/TrEMBL
    D6RAM3
    Conserved Domains (2) summary
    cd01203
    Location:157255
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
  5. XM_011534656.2XP_011532958.1  docking protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011532958.1

    UniProtKB/TrEMBL
    D6RAM3
    Conserved Domains (2) summary
    cd01203
    Location:157255
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
  6. XM_011534654.2XP_011532956.1  docking protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011532956.1

    UniProtKB/TrEMBL
    D6RAM3
    Conserved Domains (2) summary
    cd01203
    Location:157255
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cd14676
    Location:9123
    PH_DOK1,2,3; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 1, 2, and 3
  7. XM_017009884.1XP_016865373.1  docking protein 3 isoform X5

  8. XM_017009883.1XP_016865372.1  docking protein 3 isoform X2

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