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LSM3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated [ Homo sapiens (human) ]

Gene ID: 27258, updated on 23-Nov-2023

Summary

Official Symbol
LSM3provided by HGNC
Official Full Name
LSM3 homolog, U6 small nuclear RNA and mRNA degradation associatedprovided by HGNC
Primary source
HGNC:HGNC:17874
See related
Ensembl:ENSG00000170860 MIM:607283; AllianceGenome:HGNC:17874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMX4; USS2; YLR438C
Summary
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
Expression
Ubiquitous expression in kidney (RPKM 53.9), fat (RPKM 40.8) and 25 other tissues See more
Orthologs
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Genomic context

See LSM3 in Genome Data Viewer
Location:
3p25.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (14178817..14201122)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (14180681..14202982)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (14220317..14242622)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14165995-14166729 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14166730-14167464 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14185247-14185934 Neighboring gene transmembrane protein 43 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19499 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14190053-14190737 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14192355-14192855 Neighboring gene XPC antisense RNA 1 Neighboring gene XPC complex subunit, DNA damage recognition and repair factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19501 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14251094-14251594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14251595-14252095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14092 Neighboring gene uncharacterized LOC105376958 Neighboring gene CRISPRi-validated cis-regulatory element chr3.770 Neighboring gene CRISPRi-validated cis-regulatory element chr3.771 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:14293769-14294968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14308196-14308835 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14313268-14314040 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:14314041-14314814 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14314815-14315586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14317906-14318677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14323255-14323756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14324521-14325022 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:14332587-14333288 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14333289-14333989 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14334913-14335413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14339415-14339967 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14348760-14349494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19503 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14364440-14365033 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_64938 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:14370566-14370759 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14373654-14374183 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_64943 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14394065-14394622 Neighboring gene long intergenic non-protein coding RNA 1267

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of LSM3 homolog, U6 small nuclear RNA associated (LSM3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables U6 snRNA 3'-end binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in P-body assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA processing TAS
Traceable Author Statement
more info
PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
acts_upstream_of_or_within mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of Lsm1-7-Pat1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Lsm2-8 complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of U2-type precatalytic spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of U4/U6 x U5 tri-snRNP complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of U6 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
U6 snRNA-associated Sm-like protein LSm3
Names
LSM3 U6 small nuclear RNA and mRNA degradation associated
LSM3 homolog, U6 small nuclear RNA associated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014463.3NP_055278.1  U6 snRNA-associated Sm-like protein LSm3

    See identical proteins and their annotated locations for NP_055278.1

    Status: VALIDATED

    Source sequence(s)
    AC093495, AF182418, DB289601, DB499707
    Consensus CDS
    CCDS2619.1
    UniProtKB/Swiss-Prot
    P62310, Q6IAH0, Q9Y4Z1
    UniProtKB/TrEMBL
    B2R5H5
    Related
    ENSP00000302160.3, ENST00000306024.4
    Conserved Domains (1) summary
    cd01730
    Location:1697
    LSm3; Like-Sm protein 3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    14178817..14201122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    14180681..14202982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)