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TNFRSF21 TNF receptor superfamily member 21 [ Homo sapiens (human) ]

Gene ID: 27242, updated on 7-Dec-2018

Summary

Official Symbol
TNFRSF21provided by HGNC
Official Full Name
TNF receptor superfamily member 21provided by HGNC
Primary source
HGNC:HGNC:13469
See related
Ensembl:ENSG00000146072 MIM:605732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DR6; CD358; BM-018
Summary
This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]
Expression
Broad expression in urinary bladder (RPKM 50.6), fat (RPKM 36.4) and 23 other tissues See more
Orthologs

Genomic context

See TNFRSF21 in Genome Data Viewer
Location:
6p12.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (47231527..47309947, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (47199263..47277683, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor F1 Neighboring gene uncharacterized LOC105375081 Neighboring gene uncharacterized LOC105375082 Neighboring gene B3GNTL1 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of panic disorder in the Japanese population.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of TNFRSF21 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Apoptosis, organism-specific biosystem (from WikiPathways)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptosis-related network due to altered Notch3 in ovarian cancer, organism-specific biosystem (from WikiPathways)
    Apoptosis-related network due to altered Notch3 in ovarian cancer, organism-specific biosystemResults of pathway analysis of apoptosis-related genes in OVCAR3 cells treated with Notch3 siRNA or control siRNA.
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
    PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
  • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC31965

Gene Ontology Provided by GOA

Process Evidence Code Pubs
B cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adaptive immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonal fasciculation IEA
Inferred from Electronic Annotation
more info
 
cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
humoral immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
humoral immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
myelination ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of B cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-10 secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of interleukin-10 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-13 secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of interleukin-13 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-5 secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of interleukin-5 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of myelination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
oligodendrocyte apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oligodendrocyte apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
regulation of oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 21
Names
TNFR-related death receptor 6
death receptor 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014452.5NP_055267.1  tumor necrosis factor receptor superfamily member 21 precursor

    See identical proteins and their annotated locations for NP_055267.1

    Status: REVIEWED

    Source sequence(s)
    AY358304, HY007775
    Consensus CDS
    CCDS4921.1
    UniProtKB/Swiss-Prot
    O75509
    UniProtKB/TrEMBL
    A0A024RD71
    Related
    ENSP00000296861.2, ENST00000296861.2
    Conserved Domains (3) summary
    cd08778
    Location:414497
    Death_TNFRSF21; Death domain of tumor necrosis factor receptor superfamily member 21
    cd10583
    Location:53211
    TNFRSF21; Tumor necrosis factor receptor superfamily member 21 (TNFRSF21), also known as death receptor (DR6)
    cl14633
    Location:594654
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    47231527..47309947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010744.2XP_016866233.1  tumor necrosis factor receptor superfamily member 21 isoform X1

    Conserved Domains (1) summary
    cd10583
    Location:53211
    TNFRSF21; Tumor necrosis factor receptor superfamily member 21 (TNFRSF21), also known as death receptor (DR6)
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