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SULT1C4 sulfotransferase family 1C member 4 [ Homo sapiens (human) ]

Gene ID: 27233, updated on 26-Jul-2021

Summary

Official Symbol
SULT1C4provided by HGNC
Official Full Name
sulfotransferase family 1C member 4provided by HGNC
Primary source
HGNC:HGNC:11457
See related
Ensembl:ENSG00000198075 MIM:608357
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SULT1C; SULT1C2
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. [provided by RefSeq, Jul 2008]
Expression
Broad expression in gall bladder (RPKM 13.7), ovary (RPKM 9.3) and 15 other tissues See more
Orthologs
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Genomic context

See SULT1C4 in Genome Data Viewer
Location:
2q12.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (108377954..108388989)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (108994410..109005445)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 1C member 2 pseudogene 1 Neighboring gene GMCL1 pseudogene 2 Neighboring gene small integral membrane protein 12 pseudogene 1 Neighboring gene GRIP and coiled-coil domain containing 2 Neighboring gene GCC2 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of sulfotransferase family, cytosolic, 1C, member 4 (SULT1C4) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC34422, MGC149521

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aryl sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aryl sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sulfotransferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sulfotransferase 1C4
Names
ST1C4
SULT1C#2
sulfotransferase 1C2
sulfotransferase family, cytosolic, 1C, member 2
sulfotransferase family, cytosolic, 1C, member 4
sulfotransferase family, cytosolic, 1C, member C2
NP_001308699.1
NP_006579.2
XP_016859296.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321770.2NP_001308699.1  sulfotransferase 1C4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC068941, BC058861, HY118496
    Consensus CDS
    CCDS82492.1
    UniProtKB/Swiss-Prot
    O75897
    UniProtKB/TrEMBL
    Q6PD90
    Related
    ENSP00000387225.3, ENST00000409309.3
    Conserved Domains (1) summary
    pfam00685
    Location:45219
    Sulfotransfer_1; Sulfotransferase domain
  2. NM_006588.4NP_006579.2  sulfotransferase 1C4 isoform 1

    See identical proteins and their annotated locations for NP_006579.2

    Status: REVIEWED

    Source sequence(s)
    AC068941, BC125043
    Consensus CDS
    CCDS2077.1
    UniProtKB/Swiss-Prot
    O75897
    Related
    ENSP00000272452.2, ENST00000272452.7
    Conserved Domains (1) summary
    pfam00685
    Location:45294
    Sulfotransfer_1; Sulfotransferase domain

RNA

  1. NR_135776.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC068941
  2. NR_135779.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC068941

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    108377954..108388989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003807.1XP_016859296.1  sulfotransferase 1C4 isoform X1

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