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Cartpt CART prepropeptide [ Mus musculus (house mouse) ]

Gene ID: 27220, updated on 10-Mar-2024

Summary

Official Symbol
Cartptprovided by MGI
Official Full Name
CART prepropeptideprovided by MGI
Primary source
MGI:MGI:1351330
See related
Ensembl:ENSMUSG00000021647 AllianceGenome:MGI:1351330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cart
Summary
This gene encodes preproprotein isoforms that are processed into multiple biologically active peptides. Expression of this gene is regulated by cocaine and other drugs, and is associated with feeding/appetite and stress response. Mice lacking the encoded protein are predisposed to obesity. Deficiency of the encoded protein in mice results in pancreatic islet dysfunction, impaired insulin secretion and glucose intolerance. Alternative splicing results in multiple transcript variants encoding different isoforms, which are subsequently processed into mature peptides. [provided by RefSeq, Jul 2015]
Expression
Biased expression in CNS E11.5 (RPKM 6.1), stomach adult (RPKM 5.5) and 12 other tissues See more
Orthologs
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Genomic context

See Cartpt in Genome Data Viewer
Location:
13 52.9 cM; 13 D1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100034991..100037191, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (99898483..99910179, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26559 Neighboring gene STARR-seq mESC enhancer starr_35465 Neighboring gene STARR-seq mESC enhancer starr_35466 Neighboring gene predicted gene, 24471 Neighboring gene STARR-seq mESC enhancer starr_35468 Neighboring gene STARR-seq mESC enhancer starr_35469 Neighboring gene predicted gene, 41039 Neighboring gene methylcrotonoyl-Coenzyme A carboxylase 2 (beta) Neighboring gene STARR-positive B cell enhancer ABC_E1885

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (6) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables neuropeptide hormone activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adult feeding behavior IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adult feeding behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of appetite IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of appetite IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of appetite ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of bone resorption IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glucagon secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of osteoclast differentiation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within neuropeptide signaling pathway TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of bone remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in somatostatin secretion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cocaine- and amphetamine-regulated transcript protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081493.2NP_001074962.1  cocaine- and amphetamine-regulated transcript protein isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001074962.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK134656, AV341177, CO427341
    Consensus CDS
    CCDS88509.1
    UniProtKB/TrEMBL
    Q3UY31, Q3UYI4
    Related
    ENSMUSP00000152981.2, ENSMUST00000224142.2
    Conserved Domains (1) summary
    pfam06373
    Location:48116
    CART; Cocaine and amphetamine regulated transcript protein (CART)
  2. NM_013732.7NP_038760.3  cocaine- and amphetamine-regulated transcript protein isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_038760.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK134656, AV341177, BC056431, CO427341
    Consensus CDS
    CCDS36763.1
    UniProtKB/Swiss-Prot
    P56388, Q9QXZ8
    UniProtKB/TrEMBL
    Q3UY31
    Related
    ENSMUSP00000022150.7, ENSMUST00000022150.8
    Conserved Domains (1) summary
    pfam06373
    Location:67129
    CART; Cocaine and amphetamine regulated transcript protein (CART)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    100034991..100037191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)