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CARTPT CART prepropeptide [ Homo sapiens (human) ]

Gene ID: 9607, updated on 22-Aug-2020

Summary

Official Symbol
CARTPTprovided by HGNC
Official Full Name
CART prepropeptideprovided by HGNC
Primary source
HGNC:HGNC:24323
See related
Ensembl:ENSG00000164326 MIM:602606
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CART
Summary
This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active peptides. These peptides play a role in appetite, energy balance, maintenance of body weight, reward and addiction, and the stress response. Expression of a similar gene transcript in rodents is upregulated following administration of cocaine and amphetamine. Mutations in this gene are associated with susceptibility to obesity in humans. [provided by RefSeq, Feb 2016]
Expression
Biased expression in adrenal (RPKM 51.3), brain (RPKM 5.7) and 1 other tissue See more
Orthologs

Genomic context

See CARTPT in Genome Data Viewer
Location:
5q13.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (71719275..71721045)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (71014990..71016875)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 12 Neighboring gene methylcrotonoyl-CoA carboxylase 2 Neighboring gene catenin beta 1 pseudogene Neighboring gene uncharacterized LOC105379027

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia.
GeneReviews: Not available
Obesity
MedGen: C0028754 OMIM: 601665 GeneReviews: Not available
Compare labs

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
neuropeptide hormone activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
activation of MAPKK activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
adult feeding behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cellular glucose homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of appetite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of appetite ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of appetite TAS
Traceable Author Statement
more info
PubMed 
negative regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of glucagon secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of osteoclast differentiation TAS
Traceable Author Statement
more info
PubMed 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epinephrine secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transmission of nerve impulse IDA
Inferred from Direct Assay
more info
PubMed 
regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
somatostatin secretion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cocaine- and amphetamine-regulated transcript protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015988.1 RefSeqGene

    Range
    5113..6883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004291.4NP_004282.1  cocaine- and amphetamine-regulated transcript protein preproprotein

    See identical proteins and their annotated locations for NP_004282.1

    Status: REVIEWED

    Source sequence(s)
    AI417979, BC029882
    Consensus CDS
    CCDS4011.1
    UniProtKB/Swiss-Prot
    Q16568
    Related
    ENSP00000296777.4, ENST00000296777.5
    Conserved Domains (1) summary
    pfam06373
    Location:48116
    CART; Cocaine and amphetamine regulated transcript protein (CART)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    71719275..71721045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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