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Srsf12 serine and arginine-rich splicing factor 12 [ Mus musculus (house mouse) ]

Gene ID: 272009, updated on 2-Nov-2024

Summary

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Official Symbol
Srsf12provided by MGI
Official Full Name
serine and arginine-rich splicing factor 12provided by MGI
Primary source
MGI:MGI:2661424
See related
Ensembl:ENSMUSG00000054679 AllianceGenome:MGI:2661424
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Srrp; Sfrs13b; Srsf13b; B830039L16
Summary
Predicted to be involved in mRNA 5'-splice site recognition and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleus. Orthologous to human SRSF12 (serine and arginine rich splicing factor 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 9.0), whole brain E14.5 (RPKM 5.0) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Srsf12 in Genome Data Viewer
Location:
4 A5; 4 14.73 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (33208991..33233344)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (33208991..33233343)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09882 Neighboring gene peptidase M20 domain containing 2 Neighboring gene predicted gene 11930 Neighboring gene STARR-positive B cell enhancer ABC_E9235 Neighboring gene STARR-positive B cell enhancer ABC_E6159 Neighboring gene STARR-seq mESC enhancer starr_09889 Neighboring gene STARR-seq mESC enhancer starr_09890 Neighboring gene proline-rich nuclear receptor coactivator 1 Neighboring gene STARR-seq mESC enhancer starr_09892 Neighboring gene STARR-positive B cell enhancer ABC_E833 Neighboring gene STARR-seq mESC enhancer starr_09894 Neighboring gene RNA guanylyltransferase and 5'-phosphatase Neighboring gene STARR-seq mESC enhancer starr_09895 Neighboring gene STARR-seq mESC enhancer starr_09897 Neighboring gene microRNA 8118

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. UPF2 is a critical regulator of liver development, function and regeneration. Thoren LA, et al. PLoS One, 2010 Jul 19. PMID 20657840, Free PMC Article
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in mRNA 5'-splice site recognition IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA 5'-splice site recognition ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/arginine-rich splicing factor 12
Names
serine-arginine repressor protein
serine/arginine-rich splicing factor 13B
splicing factor, arginine/serine-rich 13B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356473.2 → NP_001343402.1  serine/arginine-rich splicing factor 12 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK046869, BB028293, BB871710
    Conserved Domains (1) summary
    cd12312
    Location:10 → 93
    RRM_SRSF10_SRSF12; RNA recognition motif in serine/arginine-rich splicing factor SRSF10, SRSF12 and similar proteins

  2. NM_001372518.1 → NP_001359447.1  serine/arginine-rich splicing factor 12 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK046869, BB028293, BB871710
    Consensus CDS
    CCDS89725.1
    UniProtKB/TrEMBL
    A3KG57
    Related
    ENSMUSP00000103794.2, ENSMUST00000108159.2
    Conserved Domains (1) summary
    cd12312
    Location:10 → 93
    RRM_SRSF10_SRSF12; RNA recognition motif in serine/arginine-rich splicing factor SRSF10, SRSF12 and similar proteins

  3. NM_001372519.1 → NP_001359448.1  serine/arginine-rich splicing factor 12 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AK046869, AL670464, BB028293, BB646028

  4. NM_177774.5 → NP_808442.2  serine/arginine-rich splicing factor 12 isoform 2

    See identical proteins and their annotated locations for NP_808442.2

    Status: VALIDATED

    Source sequence(s)
    AK046869, AL670464, BB028293
    Consensus CDS
    CCDS18022.1
    UniProtKB/Swiss-Prot
    Q8C8K3
    Related
    ENSMUSP00000067939.2, ENSMUST00000067864.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    33208991..33233344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164170.1 → XP_036020063.1  serine/arginine-rich splicing factor 12 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C8K3.2 GenPept UniProtKB/Swiss-Prot:Q8C8K3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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