U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Srsf12 serine and arginine-rich splicing factor 12 [ Mus musculus (house mouse) ]

Gene ID: 272009, updated on 8-Feb-2024

Summary

Official Symbol
Srsf12provided by MGI
Official Full Name
serine and arginine-rich splicing factor 12provided by MGI
Primary source
MGI:MGI:2661424
See related
Ensembl:ENSMUSG00000054679 AllianceGenome:MGI:2661424
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Srrp; Sfrs13b; Srsf13b; B830039L16
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA 5'-splice site recognition and regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleus. Predicted to be active in nuclear speck. Orthologous to human SRSF12 (serine and arginine rich splicing factor 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 9.0), whole brain E14.5 (RPKM 5.0) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Srsf12 in Genome Data Viewer
Location:
4 A5; 4 14.73 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (33208991..33233344)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (33208991..33233343)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09882 Neighboring gene peptidase M20 domain containing 2 Neighboring gene predicted gene 11930 Neighboring gene STARR-positive B cell enhancer ABC_E9235 Neighboring gene STARR-positive B cell enhancer ABC_E6159 Neighboring gene STARR-seq mESC enhancer starr_09889 Neighboring gene STARR-seq mESC enhancer starr_09890 Neighboring gene proline-rich nuclear receptor coactivator 1 Neighboring gene STARR-seq mESC enhancer starr_09892 Neighboring gene STARR-positive B cell enhancer ABC_E833 Neighboring gene STARR-seq mESC enhancer starr_09894 Neighboring gene RNA guanylyltransferase and 5'-phosphatase Neighboring gene STARR-seq mESC enhancer starr_09895 Neighboring gene STARR-seq mESC enhancer starr_09897 Neighboring gene microRNA 8118

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

General protein information

Preferred Names
serine/arginine-rich splicing factor 12
Names
serine-arginine repressor protein
serine/arginine-rich splicing factor 13B
splicing factor, arginine/serine-rich 13B

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356473.2NP_001343402.1  serine/arginine-rich splicing factor 12 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK046869, BB028293, BB871710
    Conserved Domains (1) summary
    cd12312
    Location:1093
    RRM_SRSF10_SRSF12; RNA recognition motif in serine/arginine-rich splicing factor SRSF10, SRSF12 and similar proteins
  2. NM_001372518.1NP_001359447.1  serine/arginine-rich splicing factor 12 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK046869, BB028293, BB871710
    Consensus CDS
    CCDS89725.1
    UniProtKB/TrEMBL
    A3KG57
    Related
    ENSMUSP00000103794.2, ENSMUST00000108159.2
    Conserved Domains (1) summary
    cd12312
    Location:1093
    RRM_SRSF10_SRSF12; RNA recognition motif in serine/arginine-rich splicing factor SRSF10, SRSF12 and similar proteins
  3. NM_001372519.1NP_001359448.1  serine/arginine-rich splicing factor 12 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AK046869, AL670464, BB028293, BB646028
  4. NM_177774.5NP_808442.2  serine/arginine-rich splicing factor 12 isoform 2

    See identical proteins and their annotated locations for NP_808442.2

    Status: VALIDATED

    Source sequence(s)
    AK046869, AL670464, BB028293
    Consensus CDS
    CCDS18022.1
    UniProtKB/Swiss-Prot
    Q8C8K3
    Related
    ENSMUSP00000067939.2, ENSMUST00000067864.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    33208991..33233344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164170.1XP_036020063.1  serine/arginine-rich splicing factor 12 isoform X1