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SRSF12 serine and arginine rich splicing factor 12 [ Homo sapiens (human) ]

Gene ID: 135295, updated on 10-Oct-2019

Summary

Official Symbol
SRSF12provided by HGNC
Official Full Name
serine and arginine rich splicing factor 12provided by HGNC
Primary source
HGNC:HGNC:21220
See related
Ensembl:ENSG00000154548
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SFRS19; SRrp35; SFRS13B
Expression
Biased expression in testis (RPKM 7.8), brain (RPKM 2.4) and 6 other tissues See more
Orthologs

Genomic context

See SRSF12 in Genome Data Viewer
Location:
6q15
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (89095957..89118071, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (89805678..89827800, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene proline rich nuclear receptor coactivator 1 Neighboring gene RNA, 7SL, cytoplasmic 336, pseudogene Neighboring gene peptidase M20 domain containing 2 Neighboring gene Sharpr-MPRA regulatory region 5254 Neighboring gene uncharacterized LOC101929004

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ14459, FLJ33484, FLJ41221

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
RS domain binding NAS
Non-traceable Author Statement
more info
PubMed 
unfolded protein binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
mRNA 5'-splice site recognition IDA
Inferred from Direct Assay
more info
PubMed 
mRNA cis splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
spliceosomal tri-snRNP complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/arginine-rich splicing factor 12
Names
35 kDa SR repressor protein
SR splicing factor 12
serine-arginine repressor protein (35 kDa)
splicing factor, arginine/serine-rich 13B
splicing factor, arginine/serine-rich 19

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080743.5NP_542781.3  serine/arginine-rich splicing factor 12

    See identical proteins and their annotated locations for NP_542781.3

    Status: VALIDATED

    Source sequence(s)
    AA889416, AF449428, AL353135, BC021715, BP244338
    Consensus CDS
    CCDS47459.1
    UniProtKB/Swiss-Prot
    Q8WXF0
    Related
    ENSP00000414302.2, ENST00000452027.3
    Conserved Domains (2) summary
    cd12312
    Location:1093
    RRM_SRSF10_SRSF12; RNA recognition motif in serine/arginine-rich splicing factor SRSF10, SRSF12 and similar proteins
    cl25887
    Location:12211
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    89095957..89118071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010292.1XP_016865781.1  serine/arginine-rich splicing factor 12 isoform X1

    UniProtKB/Swiss-Prot
    Q8WXF0
    Conserved Domains (2) summary
    cd12312
    Location:1093
    RRM_SRSF10_SRSF12; RNA recognition motif in serine/arginine-rich splicing factor SRSF10, SRSF12 and similar proteins
    cl25887
    Location:12211
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  2. XM_006715348.2XP_006715411.1  serine/arginine-rich splicing factor 12 isoform X3

    See identical proteins and their annotated locations for XP_006715411.1

    UniProtKB/TrEMBL
    B3KVR7
  3. XM_011535483.2XP_011533785.1  serine/arginine-rich splicing factor 12 isoform X2

    Conserved Domains (2) summary
    COG0724
    Location:977
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12312
    Location:878
    RRM_SRSF10_SRSF12; RNA recognition motif in serine/arginine-rich splicing factor SRSF10, SRSF12 and similar proteins
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