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Tbck TBC1 domain containing kinase [ Mus musculus (house mouse) ]

Gene ID: 271981, updated on 26-Sep-2022

Summary

Official Symbol
Tbckprovided by MGI
Official Full Name
TBC1 domain containing kinaseprovided by MGI
Primary source
MGI:MGI:2445052
See related
Ensembl:ENSMUSG00000028030 AllianceGenome:MGI:2445052
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tbckl; 9430001M19; 1700120J03Rik; A630047E20Rik; C030007I09Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including activation of GTPase activity; intracellular protein transport; and regulation of TOR signaling. Predicted to be located in cytoplasm; midbody; and mitotic spindle. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human TBCK (TBC1 domain containing kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 2.2), whole brain E14.5 (RPKM 2.1) and 28 other tissues See more
Orthologs
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Genomic context

See Tbck in Genome Data Viewer
Location:
3; 3 G3
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (132389874..132547451)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (132684113..132841688)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene GIMAP family P-loop NTPase domain containing 1 Neighboring gene predicted gene 9402 Neighboring gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 Neighboring gene predicted gene, 30294 Neighboring gene predicted gene, 22322 Neighboring gene predicted gene, 29811 Neighboring gene heat shock protein 90 alpha (cytosolic), class B member 1 pseudogene Neighboring gene nephronectin Neighboring gene predicted gene, 23196

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables ATP binding NAS
Non-traceable Author Statement
more info
PubMed 
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT enables protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
TBC domain-containing protein kinase-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163455.2NP_001156927.1  TBC domain-containing protein kinase-like protein

    Status: VALIDATED

    Source sequence(s)
    AC135118, AC139942, AK007218, AK034533, AK081215, CN720994
    Consensus CDS
    CCDS51070.1
    UniProtKB/Swiss-Prot
    Q8BM85
    UniProtKB/TrEMBL
    E9Q1W7
    Related
    ENSMUSP00000129205.2, ENSMUST00000169172.5
    Conserved Domains (4) summary
    smart00164
    Location:467671
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    smart00220
    Location:43273
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl00125
    Location:771882
    RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
    cl21453
    Location:43271
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    132389874..132547451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501553.4XP_006501616.1  TBC domain-containing protein kinase-like protein isoform X2

    Conserved Domains (2) summary
    smart00164
    Location:467671
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    smart00220
    Location:43273
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  2. XM_036163128.1XP_036019021.1  TBC domain-containing protein kinase-like protein isoform X1

    Conserved Domains (3) summary
    smart00164
    Location:328532
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd01525
    Location:632743
    RHOD_Kc; Member of the Rhodanese Homology Domain superfamily. Included in this CD are the rhodanese-like domains found C-terminal of the serine/threonine protein kinases catalytic (S_TKc) domain and the Tre-2, BUB2p, Cdc16p (TBC) domain. The putative active site ...
    cl21453
    Location:12134
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001783696.2 RNA Sequence

  2. XR_004941333.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173032.3: Suppressed sequence

    Description
    NM_173032.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears incomplete at the 3' end.