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IL36B interleukin 36 beta [ Homo sapiens (human) ]

Gene ID: 27177, updated on 8-Jul-2021

Summary

Official Symbol
IL36Bprovided by HGNC
Official Full Name
interleukin 36 betaprovided by HGNC
Primary source
HGNC:HGNC:15564
See related
Ensembl:ENSG00000136696 MIM:605508
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FIL1; FIL1H; IL1F8; IL1H2; IL-1F8; IL-1H2; IL1-ETA; FIL1-(ETA); FILI-(ETA)
Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 1.1) and esophagus (RPKM 0.5) See more
Orthologs
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Genomic context

See IL36B in Genome Data Viewer
Location:
2q14.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (113022089..113052867, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113779666..113810444, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene POLR2D pseudogene 1 Neighboring gene interleukin 36 alpha Neighboring gene interleukin 36 receptor antagonist Neighboring gene interleukin 1 family member 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126880, MGC126882

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-1 receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in immune response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response to antigenic stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of T cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-36 beta
Names
FIL1 eta
IL-1 eta
IL-1F8 (FIL1-eta)
IL1F8 (Canonical product IL-1F8a)
Interleukin-1 Superfamily e
family of interleukin 1-eta
interleukin 1 family, member 8 (eta)
interleukin-1 eta
interleukin-1 family member 8
interleukin-1 homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014438.5NP_055253.2  interleukin-36 beta isoform 1

    See identical proteins and their annotated locations for NP_055253.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes a longer isoform (1).
    Source sequence(s)
    AC016724, AF200494
    Consensus CDS
    CCDS2109.1
    UniProtKB/Swiss-Prot
    Q9NZH7
    Related
    ENSP00000259213.4, ENST00000259213.9
    Conserved Domains (1) summary
    cl00094
    Location:1287
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  2. NM_173178.3NP_775270.1  interleukin-36 beta isoform 2

    See identical proteins and their annotated locations for NP_775270.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' region, which includes a part of the coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC016724, AF201833, CA441070
    Consensus CDS
    CCDS2110.1
    UniProtKB/Swiss-Prot
    Q9NZH7
    Related
    ENSP00000328420.2, ENST00000327407.2
    Conserved Domains (1) summary
    cl00094
    Location:12153
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    113022089..113052867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510962.1XP_011509264.1  interleukin-36 beta isoform X1

    See identical proteins and their annotated locations for XP_011509264.1

    UniProtKB/Swiss-Prot
    Q9NZH7
    Conserved Domains (1) summary
    cl00094
    Location:12153
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
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