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Il36b interleukin 36B [ Mus musculus (house mouse) ]

Gene ID: 69677, updated on 5-Jan-2023

Summary

Official Symbol
Il36bprovided by MGI
Official Full Name
interleukin 36Bprovided by MGI
Primary source
MGI:MGI:1916927
See related
Ensembl:ENSMUSG00000026985 AllianceGenome:MGI:1916927
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
If36b; Il1f8; 2310043N20Rik
Summary
Enables cytokine activity. Acts upstream of or within positive regulation of T cell differentiation and positive regulation of interleukin-6 production. Located in extracellular space. Orthologous to human IL36B (interleukin 36 beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Il36b in Genome Data Viewer
Location:
2 A3; 2 16.21 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24043184..24050115)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24153172..24160103)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene histamine N-methyltransferase Neighboring gene TATA box binding protein like 2 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 pseudogene Neighboring gene interleukin 36G

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables interleukin-1 receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response to antigenic stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of interleukin-6 production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of T cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-6 production IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interleukin-36 beta
Names
IL-1F8
interleukin 1 family, member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027163.4NP_081439.1  interleukin-36 beta

    See identical proteins and their annotated locations for NP_081439.1

    Status: PROVISIONAL

    Source sequence(s)
    BC119517
    Consensus CDS
    CCDS38063.1
    UniProtKB/Swiss-Prot
    Q8R461, Q9D6Z6
    UniProtKB/TrEMBL
    Q08EA6
    Related
    ENSMUSP00000028363.2, ENSMUST00000028363.2
    Conserved Domains (1) summary
    cl00094
    Location:37180
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    24043184..24050115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)