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CHIA chitinase acidic [ Homo sapiens (human) ]

Gene ID: 27159, updated on 1-Aug-2020

Summary

Official Symbol
CHIAprovided by HGNC
Official Full Name
chitinase acidicprovided by HGNC
Primary source
HGNC:HGNC:17432
See related
Ensembl:ENSG00000134216 MIM:606080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHIT2; AMCASE; TSA1902
Summary
The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Expression
Biased expression in stomach (RPKM 2.7), lung (RPKM 1.9) and 2 other tissues See more
Orthologs

Genomic context

See CHIA in Genome Data Viewer
Location:
1p13.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (111290851..111320566)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (111833474..111863188)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chitinase, acidic pseudogene 1 Neighboring gene chitinase, acidic pseudogene 2 Neighboring gene uncharacterized LOC105378903 Neighboring gene primary cilia formation

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp313J1722

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
chitinase activity NAS
Non-traceable Author Statement
more info
PubMed 
chitinase activity TAS
Traceable Author Statement
more info
 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
chitin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chitin catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
chitin metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
polysaccharide catabolic process IEA
Inferred from Electronic Annotation
more info
 
polysaccharide digestion TAS
Traceable Author Statement
more info
 
positive regulation of chemokine secretion IDA
Inferred from Direct Assay
more info
PubMed 
production of molecular mediator involved in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
acidic mammalian chitinase
Names
lung-specific protein TSA1902
NP_001035713.1
NP_001244930.1
NP_001244931.1
NP_001244932.1
NP_001244933.1
NP_001244934.1
NP_068569.2
NP_970615.2
XP_006710640.1
XP_016856536.1
XP_016856537.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040623.3NP_001035713.1  acidic mammalian chitinase isoform b

    See identical proteins and their annotated locations for NP_001035713.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks exons in the 5' end of the coding region compared to variant 4. The resulting isoform (b, also known as TSA1902-S) is shorter at the N-terminus compared to isoform a. Variants 3, 6, 8, and 9 all encode the same isoform (b).
    Source sequence(s)
    AB025008, AF290004, AK290702, AL513202, AY789445, BC036339
    Consensus CDS
    CCDS58017.1
    UniProtKB/Swiss-Prot
    Q9BZP6
    UniProtKB/TrEMBL
    A8K3T7
    Conserved Domains (3) summary
    smart00494
    Location:268315
    ChtBD2; Chitin-binding domain type 2
    smart00636
    Location:1204
    Glyco_18; Glyco_18 domain
    cl10447
    Location:1226
    GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
  2. NM_001258001.2NP_001244930.1  acidic mammalian chitinase isoform a

    See identical proteins and their annotated locations for NP_001244930.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an exon in the 5' coding region and initiates translation at a downstream AUG compared to variant 4. The encoded isoform (a, also known as TSA1902-L) has a shorter N-terminus and lacks a signal peptide compared to isoform c. Variants 2, 5, and 7 all encode the same isoform (a).
    Source sequence(s)
    AK290702, AL513202, BC036339
    Consensus CDS
    CCDS832.1
    UniProtKB/Swiss-Prot
    Q9BZP6
    UniProtKB/TrEMBL
    A8K3T7
    Conserved Domains (2) summary
    cd02872
    Location:1279
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00494
    Location:321368
    ChtBD2; Chitin-binding domain type 2
  3. NM_001258002.2NP_001244931.1  acidic mammalian chitinase isoform b

    See identical proteins and their annotated locations for NP_001244931.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks exons in the 5' coding region and initiates translation at a downstream AUG compared to variant 4. The encoded isoform (b, also known as TSA1902-S) has a shorter N-terminus and lacks a signal peptide compared to isoform c. Variants 3, 6, 8, and 9 all encode the same isoform (b).
    Source sequence(s)
    AB025009, AK290702, AL356387, AL513202, BC036339
    Consensus CDS
    CCDS58017.1
    UniProtKB/Swiss-Prot
    Q9BZP6
    UniProtKB/TrEMBL
    A8K3T7
    Related
    ENSP00000436946.1, ENST00000483391.5
    Conserved Domains (3) summary
    smart00494
    Location:268315
    ChtBD2; Chitin-binding domain type 2
    smart00636
    Location:1204
    Glyco_18; Glyco_18 domain
    cl10447
    Location:1226
    GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
  4. NM_001258003.2NP_001244932.1  acidic mammalian chitinase isoform a

    See identical proteins and their annotated locations for NP_001244932.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks exons in the 5' coding region and initiates translation at a downstream AUG compared to variant 4. The encoded isoform (a, also known as TSA1902-L) has a shorter N-terminus and lacks a signal peptide compared to isoform c. Variants 2, 5, and 7 all encode the same isoform (a).
    Source sequence(s)
    AK290702, AL513202, AY825504, BC036339
    Consensus CDS
    CCDS832.1
    UniProtKB/Swiss-Prot
    Q9BZP6
    UniProtKB/TrEMBL
    A8K3T7, Q2VT96
    Conserved Domains (2) summary
    cd02872
    Location:1279
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00494
    Location:321368
    ChtBD2; Chitin-binding domain type 2
  5. NM_001258004.2NP_001244933.1  acidic mammalian chitinase isoform b

    See identical proteins and their annotated locations for NP_001244933.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an exon and contains another exon in the 5' coding region, initiating translation at a downstream AUG compared to variant 4. The encoded isoform (b, also known as TSA1902-S) has a shorter N-terminus and lacks a signal peptide compared to isoform c. Variants 3, 6, 8, and 9 all encode the same isoform (b).
    Source sequence(s)
    AB025008, AF290004, AK290702, AL356387, AL513202, AY911310, BC036339
    Consensus CDS
    CCDS58017.1
    UniProtKB/Swiss-Prot
    Q9BZP6
    UniProtKB/TrEMBL
    A8K3T7, Q1M0P4
    Conserved Domains (3) summary
    smart00494
    Location:268315
    ChtBD2; Chitin-binding domain type 2
    smart00636
    Location:1204
    Glyco_18; Glyco_18 domain
    cl10447
    Location:1226
    GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
  6. NM_001258005.2NP_001244934.1  acidic mammalian chitinase isoform b

    See identical proteins and their annotated locations for NP_001244934.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks exons and contains another exon in the 5' coding region, initiating translation at a downstream AUG compared to variant 4. The encoded isoform (b, also known as TSA1902-S) has a shorter N-terminus and lacks a signal peptide compared to isoform c. Variants 3, 6, 8, and 9 all encode the same isoform (b).
    Source sequence(s)
    AB025008, AF290004, AK290702, AL356387, AL513202, AY911311, BC036339
    Consensus CDS
    CCDS58017.1
    UniProtKB/Swiss-Prot
    Q9BZP6
    UniProtKB/TrEMBL
    A8K3T7, Q1M0P3
    Related
    ENSP00000338970.7, ENST00000353665.10
    Conserved Domains (3) summary
    smart00494
    Location:268315
    ChtBD2; Chitin-binding domain type 2
    smart00636
    Location:1204
    Glyco_18; Glyco_18 domain
    cl10447
    Location:1226
    GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
  7. NM_021797.4NP_068569.2  acidic mammalian chitinase isoform a

    See identical proteins and their annotated locations for NP_068569.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks exons in the 5' coding region and initiates translation at a downstream AUG compared to variant 4. The encoded isoform (a, also known as TSA1902-L) has a shorter N-terminus and lacks a signal peptide compared to isoform c. Variants 2, 5, and 7 all encode the same isoform (a).
    Source sequence(s)
    AB025008, AK290702, AL513202, BC036339
    Consensus CDS
    CCDS832.1
    UniProtKB/Swiss-Prot
    Q9BZP6
    UniProtKB/TrEMBL
    A8K3T7
    Related
    ENSP00000387671.1, ENST00000422815.5
    Conserved Domains (2) summary
    cd02872
    Location:1279
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00494
    Location:321368
    ChtBD2; Chitin-binding domain type 2
  8. NM_201653.4NP_970615.2  acidic mammalian chitinase isoform c precursor

    See identical proteins and their annotated locations for NP_970615.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (c). Version 1 of this RefSeq represented a distinct variant (1) encoding a different isoform (a).
    Source sequence(s)
    AB025008, AF290004, AK290702, AL513202, BC036339
    Consensus CDS
    CCDS41368.1
    UniProtKB/Swiss-Prot
    Q9BZP6
    UniProtKB/TrEMBL
    A8K3T7
    Related
    ENSP00000358755.1, ENST00000369740.6
    Conserved Domains (3) summary
    cd02872
    Location:24387
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00494
    Location:429476
    ChtBD2; Chitin-binding domain type 2
    smart00636
    Location:26365
    Glyco_18; Glyco_18 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    111290851..111320566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710577.3XP_006710640.1  acidic mammalian chitinase isoform X1

    See identical proteins and their annotated locations for XP_006710640.1

    UniProtKB/Swiss-Prot
    Q9BZP6
    Related
    ENSP00000390476.2, ENST00000451398.6
    Conserved Domains (3) summary
    smart00494
    Location:268315
    ChtBD2; Chitin-binding domain type 2
    smart00636
    Location:1204
    Glyco_18; Glyco_18 domain
    cl10447
    Location:1226
    GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
  2. XM_017001048.1XP_016856537.1  acidic mammalian chitinase isoform X2

    UniProtKB/Swiss-Prot
    Q9BZP6
    Related
    ENSP00000391132.1, ENST00000430615.1
    Conserved Domains (2) summary
    cd02872
    Location:1279
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00494
    Location:321368
    ChtBD2; Chitin-binding domain type 2
  3. XM_017001047.1XP_016856536.1  acidic mammalian chitinase isoform X1

    UniProtKB/Swiss-Prot
    Q9BZP6
    Conserved Domains (3) summary
    smart00494
    Location:268315
    ChtBD2; Chitin-binding domain type 2
    smart00636
    Location:1204
    Glyco_18; Glyco_18 domain
    cl10447
    Location:1226
    GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
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