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KCNMB3 potassium calcium-activated channel subfamily M regulatory beta subunit 3 [ Homo sapiens (human) ]

Gene ID: 27094, updated on 2-Mar-2021

Summary

Official Symbol
KCNMB3provided by HGNC
Official Full Name
potassium calcium-activated channel subfamily M regulatory beta subunit 3provided by HGNC
Primary source
HGNC:HGNC:6287
See related
Ensembl:ENSG00000171121 MIM:605222
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HBETA3; KCNMB2; KCNMBL; BKBETA3; SLOBETA3; SLO-BETA-3; K(VCA)BETA-3
Summary
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009]
Expression
Ubiquitous expression in fat (RPKM 6.7), gall bladder (RPKM 6.6) and 25 other tissues See more
Orthologs
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Genomic context

See KCNMB3 in Genome Data Viewer
Location:
3q26.32
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (179239703..179267050, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (178957491..178984838, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene zinc finger matrin-type 3 Neighboring gene uncharacterized LOC101928739 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Neighboring gene LRR binding FLII interacting protein 1 pseudogene 1 Neighboring gene CRISPRi-validated cis-regulatory element chr3.5052 Neighboring gene zinc finger protein 639

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4 PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-activated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium channel regulator activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
action potential IDA
Inferred from Direct Assay
more info
PubMed 
detection of calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
detection of calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
neuronal action potential IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcium-activated potassium channel subunit beta-3
Names
BK channel beta subunit 3
BK channel subunit beta-3
MaxiK channel beta-subunit 3
big potassium channel beta subunit 3
calcium-activated potassium channel regulatory subunit
calcium-activated potassium channel, subfamily M subunit beta-3
charybdotoxin receptor subunit beta-3
large conductance, voltage and Ca2+ activated potassium channel Maxi K beta 3 subunit
maxi K channel subunit beta-3
potassium channel subfamily M regulatory beta subunit 3
potassium large conductance calcium-activated channel, subfamily M beta member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163677.2NP_001157149.1  calcium-activated potassium channel subunit beta-3 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in both UTRs and in both the 5' and 3' coding regions, and uses an alternate translational start codon, compared to variant 4. The resulting isoform (e) has distinct N- and C-termini and is shorter than isoform d.
    Source sequence(s)
    AC007823, AC076966, AF160968, AI990131, AK304837
    Consensus CDS
    CCDS54683.1
    UniProtKB/Swiss-Prot
    Q9NPA1
    Related
    ENSP00000417091.1, ENST00000497599.5
    Conserved Domains (1) summary
    pfam03185
    Location:47151
    CaKB; Calcium-activated potassium channel, beta subunit
  2. NM_014407.3NP_055222.3  calcium-activated potassium channel subunit beta-3 isoform d

    See identical proteins and their annotated locations for NP_055222.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (d).
    Source sequence(s)
    AF139471, AF160968, AK304837, BC113851
    Consensus CDS
    CCDS3226.1
    UniProtKB/Swiss-Prot
    Q9NPA1
    Related
    ENSP00000319370.5, ENST00000314235.9
    Conserved Domains (1) summary
    pfam03185
    Location:49243
    CaKB; Calcium-activated potassium channel, beta subunit
  3. NM_171828.3NP_741979.1  calcium-activated potassium channel subunit beta-3 isoform a

    See identical proteins and their annotated locations for NP_741979.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and 5' coding region, and uses an alternate translational start codon, compared to variant 4. The resulting isoform (a) has a distinct N-terminus and is shorter than isoform d.
    Source sequence(s)
    AF139471, AF204159, AK304837
    Consensus CDS
    CCDS3225.1
    UniProtKB/Swiss-Prot
    Q9NPA1
    Related
    ENSP00000327866.2, ENST00000349697.2
    Conserved Domains (1) summary
    pfam03185
    Location:47241
    CaKB; Calcium-activated potassium channel, beta subunit
  4. NM_171829.3NP_741980.1  calcium-activated potassium channel subunit beta-3 isoform b

    See identical proteins and their annotated locations for NP_741980.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate translational start codon, compared to variant 4. The resulting isoform (b) has a distinct N-terminus and is shorter than isoform d.
    Source sequence(s)
    AC007823, AF160968, AF170916, BC082272, BM745010
    Consensus CDS
    CCDS43172.1
    UniProtKB/Swiss-Prot
    Q9NPA1
    Related
    ENSP00000418536.1, ENST00000485523.5
    Conserved Domains (1) summary
    pfam03185
    Location:27221
    CaKB; Calcium-activated potassium channel, beta subunit
  5. NM_171830.1NP_741981.1  calcium-activated potassium channel subunit beta-3 isoform c

    See identical proteins and their annotated locations for NP_741981.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses an alternate translational start codon, compared to variant 4. The resulting isoform (c) has a distinct N-terminus and is shorter than isoform d.
    Source sequence(s)
    AC007823, AF139471, BC113851
    Consensus CDS
    CCDS43173.1
    UniProtKB/Swiss-Prot
    Q9NPA1
    Related
    ENSP00000376451.2, ENST00000392685.6
    Conserved Domains (1) summary
    pfam03185
    Location:45239
    CaKB; Calcium-activated potassium channel, beta subunit

RNA

  1. NR_028135.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in its 5'-most and 3'-most exons, compared to variant 4. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC007823, AC076966, AI990131, AK304837, BC082272

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    179239703..179267050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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