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TSPAN13 tetraspanin 13 [ Homo sapiens (human) ]

Gene ID: 27075, updated on 21-Dec-2019

Summary

Official Symbol
TSPAN13provided by HGNC
Official Full Name
tetraspanin 13provided by HGNC
Primary source
HGNC:HGNC:21643
See related
Ensembl:ENSG00000106537 MIM:613139
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET6; NET-6; TM4SF13
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lung (RPKM 128.5), colon (RPKM 60.3) and 22 other tissues See more
Orthologs

Genomic context

See TSPAN13 in Genome Data Viewer
Location:
7p21.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (16753755..16784536)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (16793351..16824161)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375169 Neighboring gene ankyrin repeat and MYND domain containing 2 Neighboring gene basic leucine zipper and W2 domains 2 Neighboring gene anterior gradient 2, protein disulphide isomerase family member Neighboring gene Rho GTPase activating protein 20 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag The interaction of HIV-1 CA with human cellular tetraspanin 13 protein (TSPAN13) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22934

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium channel regulator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
tetraspanin-13
Names
tetraspan NET-6
transmembrane 4 superfamily member 13
transmembrane 4 superfamily member tetraspan NET-6
tspan-13

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014399.4NP_055214.1  tetraspanin-13

    See identical proteins and their annotated locations for NP_055214.1

    Status: REVIEWED

    Source sequence(s)
    AC073333, AK026587, AK093487, BC033863, CB852023
    Consensus CDS
    CCDS5363.1
    UniProtKB/Swiss-Prot
    O95857
    UniProtKB/TrEMBL
    Q6FGK0
    Related
    ENSP00000262067.4, ENST00000262067.5
    Conserved Domains (1) summary
    pfam00335
    Location:55187
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    16753755..16784536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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