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Ncoa4 nuclear receptor coactivator 4 [ Mus musculus (house mouse) ]

Gene ID: 27057, updated on 5-Jan-2023

Summary

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Official Symbol
Ncoa4provided by MGI
Official Full Name
nuclear receptor coactivator 4provided by MGI
Primary source
MGI:MGI:1350932
See related
Ensembl:ENSMUSG00000056234 AllianceGenome:MGI:1350932
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rfg; ARA70
Summary
Acts upstream of or within cellular iron ion homeostasis. Located in mitochondrion. Is expressed in several structures, including heart; lung; metanephros; reproductive system; and spleen. Orthologous to human NCOA4 (nuclear receptor coactivator 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 63.2), liver E14.5 (RPKM 56.4) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Ncoa4 in Genome Data Viewer
Location:
14; 14 B
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31881836..31901812)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32159879..32179855)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41127 Neighboring gene beta-microseminoprotein Neighboring gene eukaryotic translation initiation factor 5 pseudogene Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene predicted gene, 23946 Neighboring gene poly (ADP-ribose) glycohydrolase Neighboring gene tetratricopeptide repeat domain 35 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy. Li B, et al. Exp Neurol, 2023 Jan. PMID 36343680
  2. NCOA4 links iron bioavailability to DNA metabolism. Federico G, et al. Cell Rep, 2022 Aug 16. PMID 35977492
  3. Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke. Li C, et al. Pharmacol Res, 2021 Dec. PMID 34634471
  4. Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis. Das NK, et al. Cell Metab, 2020 Jan 7. PMID 31708445, Free PMC Article
  5. NCOA4 Deficiency Impairs Systemic Iron Homeostasis. Bellelli R, et al. Cell Rep, 2016 Jan 26. PMID 26776506

See all (41) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy.
    Title: cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy.
  2. NCOA4 links iron bioavailability to DNA metabolism.
    Title: NCOA4 links iron bioavailability to DNA metabolism.
  3. The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages.
    Title: The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages.
  4. Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke.
    Title: Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke.
  5. Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP/NCOA4 in non-alcoholic fatty liver disease.
    Title: Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP/NCOA4 in non-alcoholic fatty liver disease.
  6. NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice.
    Title: NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice.
  7. NCOA4 is regulated by HIF and mediates mobilization of murine hepatic iron stores after blood loss.
    Title: NCOA4 is regulated by HIF and mediates mobilization of murine hepatic iron stores after blood loss.
  8. Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.
    Title: Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.
  9. These studies demonstrate the importance of ferritin for the vectorial transfer of imported iron to mitochondria in developing red cells and of PCBP1 and NCOA4 in mediating iron flux through ferritin.
    Title: PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis.
  10. NCOA4 prevents iron accumulation and ensures efficient erythropoiesis, playing a central role in balancing iron levels in vivo.
    Title: NCOA4 Deficiency Impairs Systemic Iron Homeostasis.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC103382, 1110034E15Rik, 4432406M01Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein targeting to lysosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in response to hormone IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in autolysosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
nuclear receptor coactivator 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033988.3 → NP_001029160.1  nuclear receptor coactivator 4 isoform a

    See identical proteins and their annotated locations for NP_001029160.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC154532
    Consensus CDS
    CCDS36863.1
    UniProtKB/TrEMBL
    Q5U4H9
    Related
    ENSMUSP00000126071.2, ENSMUST00000163336.8
    Conserved Domains (1) summary
    pfam12489
    Location:231 → 326
    ARA70; Nuclear coactivator

  2. NM_001284319.2 → NP_001271248.1  nuclear receptor coactivator 4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 2. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC154532
    UniProtKB/TrEMBL
    Q8BSH1, Q9CXF3
    Conserved Domains (1) summary
    pfam12489
    Location:136 → 231
    ARA70; Nuclear coactivator

  3. NM_001402998.1 → NP_001389927.1  nuclear receptor coactivator 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154532

  4. NM_001402999.1 → NP_001389928.1  nuclear receptor coactivator 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154532

  5. NM_001403000.1 → NP_001389929.1  nuclear receptor coactivator 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154532

  6. NM_001403001.1 → NP_001389930.1  nuclear receptor coactivator 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154532

  7. NM_001403002.1 → NP_001389931.1  nuclear receptor coactivator 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154532

  8. NM_001403003.1 → NP_001389932.1  nuclear receptor coactivator 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC154532
    UniProtKB/TrEMBL
    Q5U4H9

  9. NM_001403004.1 → NP_001389933.1  nuclear receptor coactivator 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC154532

  10. NM_001403005.1 → NP_001389934.1  nuclear receptor coactivator 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC154532

  11. NM_001403006.1 → NP_001389935.1  nuclear receptor coactivator 4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154532

  12. NM_001403007.1 → NP_001389936.1  nuclear receptor coactivator 4 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC154532

  13. NM_001403008.1 → NP_001389937.1  nuclear receptor coactivator 4 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC154532

  14. NM_001403009.1 → NP_001389938.1  nuclear receptor coactivator 4 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC154532

  15. NM_001403010.1 → NP_001389939.1  nuclear receptor coactivator 4 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC154532

  16. NM_001403011.1 → NP_001389940.1  nuclear receptor coactivator 4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC154532

  17. NM_019744.5 → NP_062718.2  nuclear receptor coactivator 4 isoform a

    See identical proteins and their annotated locations for NP_062718.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC154532
    Consensus CDS
    CCDS36863.1
    UniProtKB/TrEMBL
    Q5U4H9, Q8BSH1, Q9CXF3
    Related
    ENSMUSP00000107625.4, ENSMUST00000111994.10
    Conserved Domains (1) summary
    pfam12489
    Location:231 → 326
    ARA70; Nuclear coactivator

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    31881836..31901812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316028.2 → XP_017171517.1  nuclear receptor coactivator 4 isoform X3

    Conserved Domains (1) summary
    pfam12489
    Location:230 → 325
    ARA70; Nuclear coactivator

  2. XM_006519068.5 → XP_006519131.1  nuclear receptor coactivator 4 isoform X2

    Conserved Domains (1) summary
    pfam12489
    Location:238 → 333
    ARA70; Nuclear coactivator

  3. XM_006519067.4 → XP_006519130.1  nuclear receptor coactivator 4 isoform X1

    Conserved Domains (1) summary
    pfam12489
    Location:239 → 334
    ARA70; Nuclear coactivator
Nucleotide Protein Strain
Heading Accession and Version

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