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Ncoa4 nuclear receptor coactivator 4 [ Mus musculus (house mouse) ]

Gene ID: 27057, updated on 8-Feb-2024

Summary

Official Symbol
Ncoa4provided by MGI
Official Full Name
nuclear receptor coactivator 4provided by MGI
Primary source
MGI:MGI:1350932
See related
Ensembl:ENSMUSG00000056234 AllianceGenome:MGI:1350932
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rfg; ARA70
Summary
Acts upstream of or within cellular iron ion homeostasis. Located in mitochondrion. Is expressed in several structures, including heart; lung; metanephros; reproductive system; and spleen. Orthologous to human NCOA4 (nuclear receptor coactivator 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 63.2), liver E14.5 (RPKM 56.4) and 26 other tissues See more
Orthologs
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Genomic context

See Ncoa4 in Genome Data Viewer
Location:
14 B; 14 19.4 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31881884..31901210)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32159879..32179855)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41127 Neighboring gene beta-microseminoprotein Neighboring gene eukaryotic translation initiation factor 5 pseudogene Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene STARR-seq mESC enhancer starr_36340 Neighboring gene predicted gene, 23946 Neighboring gene poly (ADP-ribose) glycohydrolase Neighboring gene STARR-positive B cell enhancer mm9_chr14:33042212-33042513 Neighboring gene tetratricopeptide repeat domain 35 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
nuclear receptor coactivator 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033988.3NP_001029160.1  nuclear receptor coactivator 4 isoform a

    See identical proteins and their annotated locations for NP_001029160.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC154532
    Consensus CDS
    CCDS36863.1
    UniProtKB/TrEMBL
    Q3UI10, Q3UJ63, Q5U4H9, Q9WV42
    Related
    ENSMUSP00000126071.2, ENSMUST00000163336.8
    Conserved Domains (1) summary
    pfam12489
    Location:231326
    ARA70; Nuclear coactivator
  2. NM_001284319.2NP_001271248.1  nuclear receptor coactivator 4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 2. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC154532
    UniProtKB/TrEMBL
    Q8BSH1
    Conserved Domains (1) summary
    pfam12489
    Location:136231
    ARA70; Nuclear coactivator
  3. NM_001402998.1NP_001389927.1  nuclear receptor coactivator 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154532
    UniProtKB/TrEMBL
    Q3UI10, Q3UJ63, Q9WV42
  4. NM_001402999.1NP_001389928.1  nuclear receptor coactivator 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154532
    UniProtKB/TrEMBL
    Q3UI10, Q3UJ63, Q9WV42
  5. NM_001403000.1NP_001389929.1  nuclear receptor coactivator 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154532
    UniProtKB/TrEMBL
    Q3UI10, Q3UJ63, Q9WV42
  6. NM_001403001.1NP_001389930.1  nuclear receptor coactivator 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154532
    UniProtKB/TrEMBL
    Q3UI10, Q3UJ63, Q9WV42
  7. NM_001403002.1NP_001389931.1  nuclear receptor coactivator 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154532
    UniProtKB/TrEMBL
    Q3UI10, Q3UJ63, Q9WV42
  8. NM_001403003.1NP_001389932.1  nuclear receptor coactivator 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC154532
    UniProtKB/TrEMBL
    Q3UI10, Q3UJ63, Q5U4H9, Q9WV42
  9. NM_001403004.1NP_001389933.1  nuclear receptor coactivator 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC154532
    UniProtKB/TrEMBL
    Q3UI10, Q3UJ63, Q9WV42
  10. NM_001403005.1NP_001389934.1  nuclear receptor coactivator 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC154532
    UniProtKB/TrEMBL
    Q3UI10, Q3UJ63, Q9WV42
  11. NM_001403006.1NP_001389935.1  nuclear receptor coactivator 4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154532
    UniProtKB/TrEMBL
    Q3UJ63
  12. NM_001403007.1NP_001389936.1  nuclear receptor coactivator 4 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC154532
    UniProtKB/TrEMBL
    Q8BSH1
  13. NM_001403008.1NP_001389937.1  nuclear receptor coactivator 4 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC154532
    UniProtKB/TrEMBL
    Q8BSH1
  14. NM_001403009.1NP_001389938.1  nuclear receptor coactivator 4 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC154532
    UniProtKB/TrEMBL
    Q8BSH1
  15. NM_001403010.1NP_001389939.1  nuclear receptor coactivator 4 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC154532
    UniProtKB/TrEMBL
    Q8BSH1
  16. NM_001403011.1NP_001389940.1  nuclear receptor coactivator 4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC154532
    UniProtKB/TrEMBL
    Q8BSH1
  17. NM_019744.5NP_062718.2  nuclear receptor coactivator 4 isoform a

    See identical proteins and their annotated locations for NP_062718.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC154532
    Consensus CDS
    CCDS36863.1
    UniProtKB/TrEMBL
    Q3UI10, Q3UJ63, Q5U4H9, Q9WV42
    Related
    ENSMUSP00000107625.4, ENSMUST00000111994.10
    Conserved Domains (1) summary
    pfam12489
    Location:231326
    ARA70; Nuclear coactivator

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    31881884..31901210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)