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NCOA4 nuclear receptor coactivator 4 [ Homo sapiens (human) ]

Gene ID: 8031, updated on 5-Jul-2020

Summary

Official Symbol
NCOA4provided by HGNC
Official Full Name
nuclear receptor coactivator 4provided by HGNC
Primary source
HGNC:HGNC:7671
See related
Ensembl:ENSG00000266412 MIM:601984
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RFG; ELE1; PTC3; ARA70
Summary
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]
Expression
Ubiquitous expression in duodenum (RPKM 113.8), liver (RPKM 75.2) and 25 other tissues See more
Orthologs

Genomic context

See NCOA4 in Genome Data Viewer
Location:
10q11.22
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (46005088..46030714, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (51565108..51590734)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene small nucleolar RNA, H/ACA box 74C-1 Neighboring gene Sharpr-MPRA regulatory region 10440 Neighboring gene uncharacterized LOC105378287 Neighboring gene microseminoprotein beta Neighboring gene ribosomal protein L23a pseudogene 61

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp762E1112

Gene Ontology Provided by GOA

Function Evidence Code Pubs
androgen receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
androgen receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
cellular iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
male gonad development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
protein targeting to lysosome IDA
Inferred from Direct Assay
more info
PubMed 
response to hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
autolysosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
nuclear receptor coactivator 4
Names
70 kDa AR-activator
70 kDa androgen receptor coactivator
NCoA-4
RET-activating gene ELE1
androgen receptor-associated protein of 70 kDa
ret fused

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023372.1 RefSeqGene

    Range
    5001..30627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145260.1NP_001138732.1  nuclear receptor coactivator 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK310849, AL162047, BC012736, DA415606, DB075100
    Consensus CDS
    CCDS73094.1
    UniProtKB/Swiss-Prot
    Q13772
    UniProtKB/TrEMBL
    Q96E88
    Related
    ENSP00000463027.1, ENST00000578454.5
    Conserved Domains (1) summary
    pfam12489
    Location:247336
    ARA70; Nuclear coactivator
  2. NM_001145261.1NP_001138733.1  nuclear receptor coactivator 4 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and use of a downstream stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK304123, AK310849, BC012736, DA415606, DB075100
    Consensus CDS
    CCDS73093.1
    UniProtKB/Swiss-Prot
    Q13772
    UniProtKB/TrEMBL
    Q96E88
    Related
    ENSP00000463455.1, ENST00000579039.2
    Conserved Domains (1) summary
    pfam12489
    Location:247336
    ARA70; Nuclear coactivator
  3. NM_001145262.1NP_001138734.1  nuclear receptor coactivator 4 isoform 3

    See identical proteins and their annotated locations for NP_001138734.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG. This variant (3) also lacks an exon in the 3' coding region, which results in a frameshift and use of a downstream stop codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and a shorter, distinct C-terminus compared to isoform 1. Variants 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK292480, BC012736
    Consensus CDS
    CCDS73092.1
    UniProtKB/Swiss-Prot
    Q13772
    UniProtKB/TrEMBL
    A0A024QZI5, Q96E88
    Related
    ENSP00000463476.1, ENST00000583565.5
    Conserved Domains (1) summary
    pfam12489
    Location:231320
    ARA70; Nuclear coactivator
  4. NM_001145263.1NP_001138735.1  nuclear receptor coactivator 4 isoform 3

    See identical proteins and their annotated locations for NP_001138735.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. This variant (4) also lacks an exon in the 3' coding region, which results in a frameshift and use of a downstream stop codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and a shorter, distinct C-terminus compared to isoform 1. Variants 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK292480, AK312325, BC012736, DB075100
    Consensus CDS
    CCDS73092.1
    UniProtKB/Swiss-Prot
    Q13772
    UniProtKB/TrEMBL
    A0A024QZI5, B2R5V0, Q96E88
    Related
    ENSP00000462943.1, ENST00000581486.5
    Conserved Domains (1) summary
    pfam12489
    Location:231320
    ARA70; Nuclear coactivator
  5. NM_005437.3NP_005428.1  nuclear receptor coactivator 4 isoform 3

    See identical proteins and their annotated locations for NP_005428.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG. This variant (5) also lacks an exon in the 3' coding region, which results in a frameshift and use of a downstream stop codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and a shorter, distinct C-terminus compared to isoform 1. Variants 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AL162047, BC012736, DA860108
    Consensus CDS
    CCDS73092.1
    UniProtKB/Swiss-Prot
    Q13772
    UniProtKB/TrEMBL
    A0A024QZI5, Q96E88
    Related
    ENSP00000464054.1, ENST00000585132.5
    Conserved Domains (1) summary
    pfam12489
    Location:231320
    ARA70; Nuclear coactivator

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    46005088..46030714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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