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G3bp1 G3BP stress granule assembly factor 1 [ Mus musculus (house mouse) ]

Gene ID: 27041, updated on 27-Feb-2024

Summary

Official Symbol
G3bp1provided by MGI
Official Full Name
G3BP stress granule assembly factor 1provided by MGI
Primary source
MGI:MGI:1351465
See related
Ensembl:ENSMUSG00000018583 AllianceGenome:MGI:1351465
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G3bp; mKIAA4115; B430204O07
Summary
Enables mRNA binding activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway. Located in cytoplasmic stress granule. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human G3BP1 (G3BP stress granule assembly factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 53.7), limb E14.5 (RPKM 33.9) and 28 other tissues See more
Orthologs
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Genomic context

See G3bp1 in Genome Data Viewer
Location:
11 B1.3; 11 33.09 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (55360521..55391722)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (55469657..55500888)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29542 Neighboring gene STARR-seq mESC enhancer starr_29544 Neighboring gene antioxidant 1 copper chaperone Neighboring gene STARR-positive B cell enhancer ABC_E373 Neighboring gene predicted gene 12235 Neighboring gene predicted gene 12238 Neighboring gene microRNA 7652 Neighboring gene predicted gene 12236 Neighboring gene glycine receptor, alpha 1 subunit

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA4115

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA/RNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosomal small subunit binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ras GTPase-activating protein-binding protein 1
Names
ATP-dependent DNA helicase VIII
G3BP-1
GAP SH3 binding protein
GAP SH3 domain-binding protein 1
GTPase activating protein (SH3 domain) binding protein 1
HDH-VIII
Ras-GTPase-activating protein SH3-domain binding protein 1
NP_001404512.1
NP_001404513.1
NP_001404514.1
NP_001404516.1
NP_038744.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417583.1NP_001404512.1  ras GTPase-activating protein-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL596207
  2. NM_001417584.1NP_001404513.1  ras GTPase-activating protein-binding protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL596207
    UniProtKB/TrEMBL
    Q3UR88
  3. NM_001417585.1NP_001404514.1  ras GTPase-activating protein-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL596207
  4. NM_001417587.1NP_001404516.1  ras GTPase-activating protein-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL596207
  5. NM_013716.3NP_038744.1  ras GTPase-activating protein-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_038744.1

    Status: VALIDATED

    Source sequence(s)
    AL596207
    Consensus CDS
    CCDS24714.1
    UniProtKB/Swiss-Prot
    P97855
    UniProtKB/TrEMBL
    Q571F9
    Related
    ENSMUSP00000018727.4, ENSMUST00000018727.4
    Conserved Domains (4) summary
    PRK13733
    Location:210310
    PRK13733; conjugal transfer protein TraV; Provisional
    COG0724
    Location:266418
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00780
    Location:7135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12463
    Location:335414
    RRM_G3BP1; RNA recognition motif found in ras GTPase-activating protein-binding protein 1 (G3BP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    55360521..55391722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)