G3bp1 GTPase activating protein (SH3 domain) binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: G3bp1provided by MGI
Official Full Name: GTPase activating protein (SH3 domain) binding protein 1provided by MGI
Primary source: MGI:MGI:1351465
See related: Ensembl:ENSMUSG00000018583 AllianceGenome:MGI:1351465
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: G3bp; mKIAA4115; B430204O07
Summary: Enables mRNA binding activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway. Located in cytoplasmic stress granule. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human G3BP1 (G3BP stress granule assembly factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 53.7), limb E14.5 (RPKM 33.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11; 11 B1.3

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (55360486..55391714)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (55469657..55500888)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules.
Title: Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules.
Huntington's disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization.
Title: Huntington's disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization.
G3BP1 Inhibition Alleviates Intracellular Nucleic Acid-Induced Autoimmune Responses.
Title: G3BP1 Inhibition Alleviates Intracellular Nucleic Acid-Induced Autoimmune Responses.
A Ca(2+)-Dependent Switch Activates Axonal Casein Kinase 2alpha Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration.
Title: A Ca(2+)-Dependent Switch Activates Axonal Casein Kinase 2α Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration.
Replacement of endogenous G3BP1 with the K376Q mutant or the RNA binding-deficient F380L/F382L mutant interfered with SG formation. Significant G3BP1 K376 acetylation was detected during SG resolution, and K376-acetylated G3BP1 was seen outside SGs. G3BP1 acetylation is regulated by histone deacetylase 6 (HDAC6) and CBP/p300.
Title: The Acetylation of Lysine-376 of G3BP1 Regulates RNA Binding and Stress Granule Dynamics.
By combining three complimentary approaches, the authors identify the host protein G3BP1 as a critical host factor required for norovirus VPg-dependent translation, identifying a new role for G3BP1 in virus-specific translation.
Title: Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation.
We show that murine norovirus (MNV) further prevents the formation of cytoplasmic stress granules, by recruiting the key host protein G3BP1 to the MNV replication complex, a recruitment that is crucial to establishing and maintaining virus replication.
Title: Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis.
this paper shows that G3BP1 promotes DNA binding and activation of cyclic GMP-AMP synthase
Title: G3BP1 promotes DNA binding and activation of cGAS.
the aberrant mutant SOD1-G3BP1 interaction affects stress granule dynamics
Title: ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics.
G3BP is involved in a new functional mechanism to regulate non-coding RNAs including intron-retaining transcripts, and thus have broad implications for neuronal gene regulation, where intron retention is widespread
Title: Preferential binding of a stable G3BP ribonucleoprotein complex to intron-retaining transcripts in mouse brain and modulation of their expression in the cerebellum.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137330 (e-PCR)
- UniSTS:219418

G3bp1 (e-PCR), detects polymorphism
- UniSTS:506914

G3bp1 (e-PCR), detects polymorphism
- UniSTS:479113

C87777 (e-PCR)
- UniSTS:180206

Homology

Homologs of the G3bp1 gene: The G3bp1 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 484 organisms have orthologs with human gene G3bp1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	ISO Inferred from Sequence Orthology more info
enables DNA/RNA helicase activity	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	ISO Inferred from Sequence Orthology more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress granule assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in stress granule assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: ras GTPase-activating protein-binding protein 1

Names: ATP-dependent DNA helicase VIII; G3BP-1; GAP SH3 binding protein; GAP SH3 domain-binding protein 1; HDH-VIII; Ras-GTPase-activating protein SH3-domain binding protein 1

NP_038744.1

EC 3.6.4.12

EC 3.6.4.13

XP_030101902.1

EC 3.6.4.12

EC 3.6.4.13

XP_030101903.1

EC 3.6.4.12

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417583.1 → NP_001404512.1 ras GTPase-activating protein-binding protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL596207
NM_001417584.1 → NP_001404513.1 ras GTPase-activating protein-binding protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL596207
NM_001417585.1 → NP_001404514.1 ras GTPase-activating protein-binding protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL596207
NM_001417587.1 → NP_001404516.1 ras GTPase-activating protein-binding protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL596207
NM_013716.3 → NP_038744.1 ras GTPase-activating protein-binding protein 1 isoform 1

See identical proteins and their annotated locations for NP_038744.1

Status: VALIDATED

Source sequence(s)

AL596207

Consensus CDS

CCDS24714.1

UniProtKB/Swiss-Prot

P97855

Related

ENSMUSP00000018727.4, ENSMUST00000018727.4

Conserved Domains (4) summary

PRK13733
Location:210 → 310

PRK13733; conjugal transfer protein TraV; Provisional

COG0724
Location:266 → 418

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd00780
Location:7 → 135

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

cd12463
Location:335 → 414

RRM_G3BP1; RNA recognition motif found in ras GTPase-activating protein-binding protein 1 (G3BP1) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

55360486..55391714

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246042.2 → XP_030101902.1 ras GTPase-activating protein-binding protein 1 isoform X1

Conserved Domains (3) summary

PRK14950
Location:150 → 261

PRK14950; DNA polymerase III subunits gamma and tau; Provisional

cd00780
Location:1 → 70

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

cl17169
Location:270 → 349

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030246043.2 → XP_030101903.1 ras GTPase-activating protein-binding protein 1 isoform X1

Conserved Domains (3) summary

PRK14950
Location:150 → 261

PRK14950; DNA polymerase III subunits gamma and tau; Provisional

cd00780
Location:1 → 70

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

cl17169
Location:270 → 349

RRM_SF; RNA recognition motif (RRM) superfamily