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G3BP1 G3BP stress granule assembly factor 1 [ Homo sapiens (human) ]

Gene ID: 10146, updated on 8-Jul-2018
Official Symbol
G3BP1provided by HGNC
Official Full Name
G3BP stress granule assembly factor 1provided by HGNC
Primary source
HGNC:HGNC:30292
See related
Ensembl:ENSG00000145907 MIM:608431; Vega:OTTHUMG00000130123
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G3BP; HDH-VIII
Summary
This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 18.3), appendix (RPKM 16.8) and 25 other tissues See more
Orthologs
See G3BP1 in Genome Data Viewer
Location:
5q33.1
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (151771915..151805354)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (151151476..151184915)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378235 Neighboring gene antioxidant 1 copper chaperone Neighboring gene uncharacterized LOC100652758 Neighboring gene Sharpr-MPRA regulatory region 5918 Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene 6 Neighboring gene glycine receptor alpha 1 Neighboring gene uncharacterized LOC112267935 Neighboring gene glutamate-ammonia ligase pseudogene 1 Neighboring gene transfer RNA-Gln (CTG) 13-1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with GTPase activating protein (SH3 domain) binding protein 1 (G3BP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Pr55(Gag) gag HIV-1 Gag inhibits G3BP1 localization in U2OS cells; inhibiting the formation of stress granules PubMed
gag HIV-1 Gag co-localizes and interacts with G3BP1 and TIAR to modulate stress granule assembly during HIV-1 infection PubMed
gag HIV-1 Gag has the ability to interfere with HIV-2 Gag induced assembly of stress granules with the protein marker G3BP1 PubMed
gag Overexpression of G3BP1 inhibits the interaction between HIV-1 Gag and eEF2 in cells, suggesting that G3BP1 competes with eEF2 binding to Gag PubMed
Tat tat GTPase activating protein (SH3 domain) binding protein 1 (G3BP1) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC111040

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent DNA helicase activity TAS
Traceable Author Statement
more info
PubMed 
ATP-dependent RNA helicase activity TAS
Traceable Author Statement
more info
PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
Ras protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
stress granule assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
ras GTPase-activating protein-binding protein 1
Names
ATP-dependent DNA helicase VIII
DNA helicase VIII
G3BP-1
GAP SH3 domain-binding protein 1
GAP binding protein
GTPase activating protein (SH3 domain) binding protein 1
Ras-GTPase-activating protein SH3-domain-binding protein
RasGAP-associated endoribonuclease G3BP
NP_005745.1
NP_938405.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005754.2NP_005745.1  ras GTPase-activating protein-binding protein 1

    See identical proteins and their annotated locations for NP_005745.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK130003, BG703413, BU517281, BX647869, BX648012
    Consensus CDS
    CCDS4319.1
    UniProtKB/Swiss-Prot
    Q13283
    UniProtKB/TrEMBL
    Q5U0Q1, Q6ZP53
    Related
    ENSP00000348578.3, OTTHUMP00000224181, ENST00000356245.7, OTTHUMT00000373965
    Conserved Domains (3) summary
    pfam06390
    Location:212320
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    cd00780
    Location:7135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12463
    Location:337416
    RRM_G3BP1; RNA recognition motif found in ras GTPase-activating protein-binding protein 1 (G3BP1) and similar proteins
  2. NM_198395.1NP_938405.1  ras GTPase-activating protein-binding protein 1

    See identical proteins and their annotated locations for NP_938405.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK130003, BX647869, BX648012
    Consensus CDS
    CCDS4319.1
    UniProtKB/Swiss-Prot
    Q13283
    UniProtKB/TrEMBL
    Q5U0Q1, Q6ZP53
    Related
    ENSP00000377681.3, OTTHUMP00000160618, ENST00000394123.7, OTTHUMT00000252431
    Conserved Domains (3) summary
    pfam06390
    Location:212320
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    cd00780
    Location:7135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12463
    Location:337416
    RRM_G3BP1; RNA recognition motif found in ras GTPase-activating protein-binding protein 1 (G3BP1) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    151771915..151805354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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